Navigation Links
Study sheds light on angiogenesis inhibitors, points to limitations, solutions
Date:3/2/2009

glioblastomas adapt to the angiogenesis-inhibiting drugs," Bergers says. "Scientists have reported results from a clinical trial in which a subset of patients developed tumor recurrence at many sites during the course of treatment with bevacizumab, an angiogenesis inhibitor. The recurrence was measured by MRI imaging."

"While anti-angiogenesis drugs are in general not proving to be an enduring success, this does not mean they aren't valuable therapies," she adds. "There is growing evidence that the drugs improve the quality of life, or even provide increased survival typically of a few months for glioblastoma patients. The drugs also can reduce edema in brain tumors and in some instances restore memory and speech."

A tumor's resistance to angiogenesis inhibitors differs from resistance to chemotherapy drugs, Bergers explains. The targets of anti-angiogenic therapy are normal cells that form the tubes of blood vessels, known as endothelial cells. Despite the fact that the drugs are still effective against these cells, resistance develops because the tumor finds additional pathways to circumvent the drug's inhibitory effect. One evasive tumor strategy involves tapping growth factors in the body other than VEGF for the new blood vessel growth they need. If the tumor can't rebuild its vasculature to a sufficient level, it can adopt another strategyto spread and become invasive.

In contrast, tumor cells resist chemotherapy by cell-intrinsic mechanisms such as mutating the gene targeted by the drug, or changing how the tumor takes up or expels the drug.

One class of anti-angiogenesis drugs works by blocking the action of an essential protein known as vascular endothelial growth factor, or VEGF, which normally stimulates new blood vessel growth. The strategy of starving tumors by depriving them of nutrients and oxygen in blood was first proposed in the early 1970s by the late Dr. Judah Folkman at Harvard Medical School. The idea took
'/>"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Thomson Reuters Study Tracks Impact of Recession on Hospitals
2. Insulin drug study shows significant improvements in more than 52,000 diabetic patients
3. Common Approaches to Member Retention by Health Insurance Plans are Ineffective, New Study Shows
4. Study Showing Improved Virologic Response with Nitazoxanide in Chronic Hepatitis C Published in Gastroenterology
5. TV viewing before the age of 2 has no cognitive benefit, study finds
6. Kaiser Permanente Study Finds Drinking Wine May Lower Risk of Barretts Esophagus, Precursor to Nations Fastest Growing Cancer, Esophageal Cancer
7. Snowblower Hand Injuries Often Extensive, Study Finds
8. UIC receives $3 million to study prostate cancer risk factors
9. NYU Langone Medical Center study shows that cochlear implant surgery is safe for the elderly
10. Many faces of diabetes in American youth: The SEARCH for diabetes in youth study
11. Atkins Responds to Recent New England Journal of Medicine Weight-Loss Diets Study Results
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study sheds light on angiogenesis inhibitors, points to limitations, solutions
(Date:7/12/2014)... News) -- Burn injuries increase in the summer as people ... experts. Among those most vulnerable to these seasonal fire hazards: ... often get burned by putting their hands on the side ... burn unit at Loyola University Medical Center in Maywood, Ill., ... of ,When you play with fire, you get burned, is ...
(Date:7/12/2014)... Lindsay, ON Canada (PRWEB) July 12, 2014 Sean ... known for throwing out special challenges to his clients. He’s also ... Girls Club. He recently found a way to combine the two ... has raised $2,000 for the Boys and Girls Club. , ... Loss Program, which started on June 23rd. Francis sent out emails ...
(Date:7/12/2014)... Using and carrying around a catheter ... from Ashland, Va., decided that there needed to be ... to conceive of our design," he said. , They ... which provides an inconspicuous way to use and carry ... as promotes comfort and peace of mind. Producible in ...
(Date:7/12/2014)... With prom shopping reaching its final days, VogueQueen.com, ... to showcase its new and trendy apparels. Recently, the ... in its online shop. Additionally, it is now providing ... gowns. According to the company’s sales manager, the promotion ... , He says, “Now, worldwide clients can order ...
(Date:7/12/2014)... Wright & Schulte LLC has filed a DePuy ... of Johnson & Johnson, on behalf of an Ohio man ... metal-on-metal DePuy Pinnacle hip replacement and had to undergo revision ... The DePuy hip lawsuit was filed July 7, 2014, in ... 3:14-cv-2427) where DePuy Pinnacle Hip lawsuit litigation is underway ...
Breaking Medicine News(10 mins):Health News:Burn Injuries More Common in Summer 2Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 2Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 3Health News:VogueQueen.com Updates Its Summer Collection With New And Trendy Evening Dresses 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 3Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 4Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 5
... people who get lots of vitamin E in their ... those who take in relatively little. Researchers once had high ... important safeguard against heart attacks. But that idea eventually faded ... some think the vitamin may protect against cancer perhaps by ...
... prostate cancer would rather find out sooner than later if ... cancer using the prostate-specific antigen test. But since PSA levels normally ... to know what a high reading is and what may just ... have to undergo repeated biopsies to determine whether they have cancer ...
... a recent study done on rats has shed light on ... brain cell in a rat can make its whiskers twitch, ... controls movement. Eventually this could help scientists develop devices paralyzed ... researchers say they thought that because the part of the ...
... ( an evolution specialist ), helped China's SARS Epidemiology ... fingerprinted virus samples from several dozen infected people and ... provides more evidence that SARS jumps from animals to ... of new cases is crucial, before viral strains have ...
... study shows there may be reason to believe we have ... brain may block unwanted memories. ,Researchers from Stanford University ... were given 36 pairs of unrelated words and asked to ... word pairs into three sets of 12. Participants were asked ...
... research presented at the annual meeting of the Radiological ... accurately detect small cancers and stones in the kidneys, ... ,Multi Detector CT Urography ( MDCTU ) scans can ... through the body from different angles. Patients are given ...
Cached Medicine News:Health News:Vitamin E Found To reduce bladder cancer risk 2Health News:Scientists Have Traced How The SARS Virus evolved 2Health News:CT Scans Said to Accurately Detect Small Cancers 2
(Date:7/11/2014)... DALLAS , July 11, 2014 ... report "Scintillator Market by Composition of Material, Application ... and others), End Product (Personal Instrument, Hand-Held Instruments, ... Forecast and Analysis to 2013 - 2020", published by MarketsandMarkets, ... a CAGR of 5.62% from 2014 to 2020, ...
(Date:7/11/2014)... On Thursday, July 10, ... Dow Jones Industrial Average finished the day 0.42% lower at ... The losses were broad based as eight out of ten ... Care Sector Index ended the day at 711.88, down 0.02%, ... month. Investor-Edge has initiated coverage on the following equities: Covidien ...
(Date:7/11/2014)... LONDON , July 11, 2014 /PRNewswire/ ... of visitors to Safety & Health Expo ... by the move to London ... senior management attending exhibition.     ... (Photo: http://photos.prnewswire.com/prnh/20140711/696892-a ) ...
Breaking Medicine Technology:Scintillator Market will be worth $479.16 Million by 2020 2Scintillator Market will be worth $479.16 Million by 2020 3Scintillator Market will be worth $479.16 Million by 2020 4Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 3Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 4UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 2UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 3UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 4
... /PRNewswire/ -- Ethicon Endo-Surgery, Inc. today announced ... IDE feasibility trial. The case, which was performed at ... Invasive Surgery, marks the first natural orifice translumenal endoscopic ... NOTES is a surgical method in which external incisions ...
... 9 Approximately ninety-one percent of dentists say patients complaining ... nationwide member survey conducted by the Academy of General Dentistry ... by a decrease in salivary function. It affects approximately ... people at risk for tooth decay. During the Academy of ...
Cached Medicine Technology:First Patient of NOTES Investigational Device Exemption (IDE) Study Successfully Treated With Ethicon Endo-Surgery Devices 2First Patient of NOTES Investigational Device Exemption (IDE) Study Successfully Treated With Ethicon Endo-Surgery Devices 3Dry Mouth Linked to Prescription and Over the Counter Drugs 2Dry Mouth Linked to Prescription and Over the Counter Drugs 3
... specifically designed for monitoring the performance ... for separation and quantification of cholesterol ... in patient serum samples. Liposure is ... and A (IDL), LDL subfractions, HDL ...
... The Lipoprint System is a high resolution diagnostic ... tested by other methods. The test procedure is ... three hours. Any abnormal value is clearly flagged. ... highly atherogenic, small dense LDL in red and ...
... the only control for monitoring ... synovial fluid samples performed manually ... also an aid for identifying ... a pathological condition present in ...
... Suitable for use with ... BR2 bilirubinometers (pediatric) and all ... instruments including Aeroset, AU Series, ... Vitros. These controls contain purified ...
Medicine Products: