Navigation Links
Study sees need for standardized evaluation of antibody response to HIV-1
Date:8/7/2008

U.S. Military HIV Research Program (USMHRP) researcher Victoria R. Polonis, Ph.D., and colleagues released findings on a study of cross-clade neutralization patterns among HIV-1 strains from six major clades in the 5 Jun 2008 issue of Virology.

Broadly neutralizing antibodies are likely to play a key role in any successful global vaccine for HIV. This study looked specifically at the role of clade in eliciting protective responses. Working with USMHRP colleague Francine McCuthan, Ph.D., researchers had access to a wide range of pure clade reagents, which they used to analyze the cross-clade neutralization patterns.

Another key goal of this study was to assess the impact of assay choice on the evaluation of cross-clade neutralization. The team examined the performance of different types of antibodies in both traditional primary cell neutralization assays and the newer, more standardized TZM-bl reporter cell line assays.

A major finding of the study was that the results of the two assay formats showed no direct correlation. This underscores the need to identify a physiologically relevant and standardized platform for reproducible measurement of neutralizing antibodies. Until such a product is available, researchers recommend that parallel evaluation with both platforms should be contemplated until a better understanding of immune correlates of protection is achieved.

Polonis and colleagues also found that the clade C antibody pool (from subjects infected with clade C from Tanzania) was broadly cross-reactive, neutralizing the greatest number of viruses in both assays. "The data is encouraging," noted Polonis. "Clade C vaccine products certainly warrant further investigation in light of several recent publications regarding potentially novel properties of the C envelope and because more than half of the global HIV-1 infections are clade C." In fact, Polonis and her team have an ongoing project to develop a clade C envelope subunit vaccine derived from acute infection.


'/>"/>

Contact: JoAnn Sperber
jsperber@hjf.org
301-294-1234
Henry M. Jackson Foundation for the Advancement of Military Medicine
Source:Eurekalert

Related medicine news :

1. Study Links Agent Orange to Prostate Cancer in Vietnam Vets
2. KLRI Receives Grant From NIH to Study Stress Resilience in Older Adults
3. Alcohol consumption declining, according to results of new study
4. UNC study: shape, not just size, impacts effectiveness of emerging nanomedicine therapies
5. Study: verbal aggression may affect childrens behavior
6. Fudan-Cinpathogen Study Shows Chronic Lymphoid Neoplasms are More Common in Shanghai Than Thought
7. First national study of diving-related injuries
8. American Cancer Society study finds high use of complementary methods among cancer survivors
9. Canadian study of colds and kids: Positive safety results for ginseng extract
10. Epilepsy drug may help alcoholics recover from dependence, small study suggests
11. Office of the Future Environment Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... ... ... With the cold weather here, many people will have to clear snow with snow blowers ... of snow, but they can be dangerous when used incorrectly. That’s why Amica Insurance ... proper use of snow blowers:, , When removing wet snow or ...
(Date:1/19/2017)... ... ... Cosmetic Town, an online plastic surgery community, begins 2017 with an update ... their readers to get the information they desire. The procedures are now listed according ... on those particular areas. , “We are excited to streamline our listings in a ...
(Date:1/19/2017)... ... 2017 , ... Bio-Optronics Inc. is proud to announce the ... to seamlessly integrate and streamline the way researchers prepare and conduct patient visits. ... and improving efficiency significantly for users – a first in the CTMS industry. ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... staff members in 2017 who are passionate about making a difference in the ... and headquartered in Tampa, UMA, a nonprofit healthcare educational institution, has more than ...
(Date:1/19/2017)... ... 2017 , ... For the third year running, Noto Insurance ... surrounding area, is inaugurating a charity event to help raise funds for ... Gehrig's disease or motor neurone disease, is a deadly neurological disorder that affects ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)...   Science Exchange , the leading marketplace ... the first five replication studies from the ... in eLife today. Despite intense scrutiny around reproducibility ... evaluation of reproducibility rates that may identify specific ... assessments of reproducibility, the results of this project ...
(Date:1/19/2017)... January 18, 2017 , , Marks E-QURE ... distribution agreement, following similar agreements in Israel ... Wound care is $2 5 billion ... E-QURE Corp. (OTCQB: EQUR), a leader in medical devices for the treatment of ... Médica Equipos Médicos S.A.S. (TeckMedica) in Colombia for the ...
(Date:1/19/2017)... , Jan. 18, 2017 The drug ... billion by 2021 from USD 1,179.20 billion in 2016, ... Increasing prevalence of chronic diseases, increasing demand for ... factors driving the growth of this market. Whereas, self-administration ... generic drugs offer significant growth opportunities for players operating ...
Breaking Medicine Technology: