Navigation Links
Study seeks to halt progression of diabetic nephropathy
Date:3/14/2011

AUGUSTA, Ga. Researchers at Georgia Health Sciences University are studying whether inhibiting an enzyme that reduces levels of a protective metabolite could halt the progression of diabetic nephropathy, or kidney disease resulting from diabetes.

With a four year, $308,000 grant from the American Heart Association, Dr. Ahmed Elmarakby, Assistant Professor of Oral Biology in the College of Dental Medicine and Pharmacology and Toxicology in the Medical College of Georgia, will study how epoxyeicosatrienoic acids, or EETs, protect the kidneys.

EETs are metabolites that guard against inflammation and high blood pressure, very useful assets considering that oxidative stress and inflammatory cytokines play a role in diabetic nephropathy.

Elmarakby hypothesizes that EETs protect kidneys by inhibiting nuclear factor kappa B from signaling inflammation and by activating hemeoxygenase-1 to counteract oxidative damage.

But while EETs are working hard to protect the kidneys, an enzyme, soluble epoxide hydrolase, causes EETs to rapidly degrade in the body. Elmarakby believes drugs that inhibit the enzyme could halt the damage, and he is testing the theory on diabetic animals.

"Diabetic nephropathy is a leading cause of end-stage renal disease, for which the only treatment now is dialysis and kidney transplant," Elmarakby said. "We hope the inhibitors could potentially be used to halt the progression of renal injury during diabetes."

About 170 million people worldwide have diabetes, and that number is expected to double within the next 25 years. Diabetic nephropathy affects about 35 percent of diabetic patients.


'/>"/>

Contact: Paula Hinely
phinely@georgiahealth.edu
706-721-3646
Georgia Health Sciences University
Source:Eurekalert  

Page: 1

Related medicine news :

1. Neuro signals study gives new insight into brain disorders
2. Text Messages May Help Smokers Kick the Addiction, Small Study Finds
3. Adults With HIV at Increased Risk of Bone Fractures, Study Finds
4. New study shows government spending preferences of Americans
5. Wayne State study links testosterone with mens ability to woo potential mates
6. Depression Seems to Increase Risk of Kidney Failure: Study
7. UTHealth study: Stem cells may provide treatment for brain injuries
8. Humans Age at Same Pace as Other Primates, Study Finds
9. Poor Diet in Pregnancy Tied to Disease in Offspring: Rat Study
10. Animal Study May Explain Low Birth Weight-Obesity Link
11. Hopkins Childrens study finds some patients with cerebral palsy have asymmetric pelvic bones
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study seeks to halt progression of diabetic nephropathy
(Date:1/19/2017)... ... January 19, 2017 , ... Aerolib ... system for Clinical and Regulatory education for Physicians, Physician Advisors, Case managers, ... education methodology of Disease Specific Documentation Improvement. , The Aerolib Learning Management ...
(Date:1/19/2017)... ... ... cold weather here, many people will have to clear snow with snow blowers or shovels ... but they can be dangerous when used incorrectly. That’s why Amica Insurance is ... of snow blowers:, , When removing wet snow or debris from ...
(Date:1/19/2017)... ... January 19, 2017 , ... WhoHaha , a digital media company ... Heart Association (AHA) to produce a three-part video series that uses humor to highlight ... of the launch of AHA’s Healthy For Good™ movement, which is designed to inspire ...
(Date:1/19/2017)... Park City, Utah (PRWEB) , ... January 19, ... ... Sundance Film Festival in a medical capacity this year. Drs. Alexander Paziotopoulos, Andrew ... Lounge to provide a condensed version of the clinic’s leading recovery program. ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... provided a new $11,250,000 senior credit facility to Sunrise, Florida-based Management Health Systems, ... were used to facilitate a recapitalization of MedPro led by Harren Equity Partners. ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , Marks E-QURE , s ... following similar agreements in Israel and Argentina ... 5 billion global market ... in medical devices for the treatment of advanced wound care, announced today it ... Colombia for the Company,s patented Bio-electrical Signal Therapy device ...
(Date:1/19/2017)... , Jan. 18, 2017   Synthetic ... clinical company developing therapeutics designed to preserve the ... patients, today confirmed plans to initiate a Phase ... modified-release reformulation of lovastatin lactone designed to reduce ... in the gut to treat the underlying ...
(Date:1/18/2017)... 18, 2017  EnteroMedics Inc. (NASDAQ: ... neuroblocking technology to treat obesity, metabolic diseases and ... an underwritten public offering of units for gross ... discounts and commissions and offering expenses payable by ... Class A Units, priced at a public offering ...
Breaking Medicine Technology: