Navigation Links
Study seeks to halt progression of diabetic nephropathy

AUGUSTA, Ga. Researchers at Georgia Health Sciences University are studying whether inhibiting an enzyme that reduces levels of a protective metabolite could halt the progression of diabetic nephropathy, or kidney disease resulting from diabetes.

With a four year, $308,000 grant from the American Heart Association, Dr. Ahmed Elmarakby, Assistant Professor of Oral Biology in the College of Dental Medicine and Pharmacology and Toxicology in the Medical College of Georgia, will study how epoxyeicosatrienoic acids, or EETs, protect the kidneys.

EETs are metabolites that guard against inflammation and high blood pressure, very useful assets considering that oxidative stress and inflammatory cytokines play a role in diabetic nephropathy.

Elmarakby hypothesizes that EETs protect kidneys by inhibiting nuclear factor kappa B from signaling inflammation and by activating hemeoxygenase-1 to counteract oxidative damage.

But while EETs are working hard to protect the kidneys, an enzyme, soluble epoxide hydrolase, causes EETs to rapidly degrade in the body. Elmarakby believes drugs that inhibit the enzyme could halt the damage, and he is testing the theory on diabetic animals.

"Diabetic nephropathy is a leading cause of end-stage renal disease, for which the only treatment now is dialysis and kidney transplant," Elmarakby said. "We hope the inhibitors could potentially be used to halt the progression of renal injury during diabetes."

About 170 million people worldwide have diabetes, and that number is expected to double within the next 25 years. Diabetic nephropathy affects about 35 percent of diabetic patients.


Contact: Paula Hinely
Georgia Health Sciences University

Page: 1

Related medicine news :

1. Neuro signals study gives new insight into brain disorders
2. Text Messages May Help Smokers Kick the Addiction, Small Study Finds
3. Adults With HIV at Increased Risk of Bone Fractures, Study Finds
4. New study shows government spending preferences of Americans
5. Wayne State study links testosterone with mens ability to woo potential mates
6. Depression Seems to Increase Risk of Kidney Failure: Study
7. UTHealth study: Stem cells may provide treatment for brain injuries
8. Humans Age at Same Pace as Other Primates, Study Finds
9. Poor Diet in Pregnancy Tied to Disease in Offspring: Rat Study
10. Animal Study May Explain Low Birth Weight-Obesity Link
11. Hopkins Childrens study finds some patients with cerebral palsy have asymmetric pelvic bones
Post Your Comments:
Related Image:
Study seeks to halt progression of diabetic nephropathy
(Date:11/27/2015)... , ... November 27, 2015 , ... According to an ... not changing the way that they are handling security in light of the recent ... security presence in an attempt to stop an attack from reaching U.S. soil. Especially ...
(Date:11/27/2015)... ... 27, 2015 , ... Lizzie’s Lice Pickers just announced a special promotion that ... of their purchase of lice treatment product. In addition, customers will receive a complimentary ... spokesperson. “Finding lice is a sure way to ruin the holidays, so we encourage ...
(Date:11/27/2015)... ... November 27, 2015 , ... Intellitec Solutions announced ... User Group (MSDSLUG). Recognized as Microsoft’s official group for end users of Dynamics ... software users, partners, industry experts and representatives. Intellitec Solutions’ membership status demonstrates their ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men and women ... healthcare organizations in the country. They have overseen financial turnarounds, shown commitment to ... the healthcare industry as a whole through their advocacy and professional efforts. , ...
(Date:11/26/2015)... ... November 26, 2015 , ... Inevitably when people think Thanksgiving, they ... to buy during the Black Friday and Cyber Monday massage chair sales ... the Internet high and low to find the best massage chair deals, they can ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the European Therapeutic Drug Monitoring ... Forecasts, Competitive Intelligence, Emerging Opportunities"  report ... ) has announced the addition ...
(Date:11/26/2015)... , November 26, 2015 ... addition of the "Radioimmunoassay Market by ... (Hospital, Pharmaceutical Industry, Academics, Clinical Diagnostic Labs), ... Global Forecast to 2020" report to ... has announced the addition of the ...
(Date:11/25/2015)... THOUSAND OAKS, Calif. , Nov. 25, 2015 /PRNewswire/ ... of a Biologics License Application (BLA) with ... Administration (FDA) for ABP 501, a biosimilar candidate to ... the first adalimumab biosimilar application submitted to the FDA ... biosimilar pathway. Sean E. Harper , M.D., ...
Breaking Medicine Technology: