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Study revises colorectal cancer risk down and other cancer risks up for women with Lynch Syndrome
Date:2/26/2013

ows us to ask questions not only about colorectal cancer in general, but about its molecular subtypes separately. These three types are included under the umbrella of colorectal cancer but have different prognoses and react differently to therapies. Effectively, they're quite different diseases," Ahnen says.

One of the study's important findings was an 11 percent lifetime risk for breast cancer after Lynch-associated endometrial cancer, 2.51 times the risk of women outside this population. Also elevated with Lynch Syndrome were lifetime risks of bladder (9 percent) and kidney (11 percent) cancers. But while the current study expands the spectrum of cancers associated with Lynch Syndrome, it also provides estimates of risk of colorectal cancer that are lower than previous estimates.

"When you think about it," Ahnen says, "most of the prior data on Lynch-associated colorectal cancer risk was from people referred to a high-risk clinic usually because of a strong family history of cancer. Of course, these people are likely to have higher cancer risk than the general population. The registry data minimizes this selection bias and allows us to look at a more representative cross-section of the colorectal cancer population. This cross-section shows a 50-60 percent lifetime risk of developing colorectal cancer in people with Lynch Syndrome, as opposed to earlier estimates of 70-80 percent risk."

"There are many remaining questions we can ask using the CCFR data," Ahnen says. "For example, what's the best way to screen people for Lynch Syndrome? Based on the risks the registry shows, should we screen all colorectal cancers for Lynch and then all family members of Lynch patients for the mutation or should we focus on some clinical subset of the population such as those with CRC at a young age? Likewise we can determine if colorectal cancers that arise from different molecular pathways are associated with different risk factor profiles, different
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Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

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