Navigation Links
Study revises colorectal cancer risk down and other cancer risks up for women with Lynch Syndrome
Date:2/26/2013

Lynch Syndrome is a heritable genetic mutation that causes colorectal, endometrial and other cancers. A cooperative study that included the University of Colorado Cancer Center, published in this month's issue of the Journal of the National Cancer Institute, revises the risk of colorectal cancer down but other cancers up for women with Lynch Syndrome who have had endometrial cancer.

"This new information helps patient care in two important ways. First, it helps us counsel women with Lynch Syndrome who have had endometrial cancer about the magnitude of their future cancer risk, which turns out to be about 55 percent over the 20 years after diagnosis of their endometrial cancer. Second, it helps fill in the picture of the spectrum of cancers that are associated with Lynch Syndrome, which includes not only colorectal and endometrial cancers, but kidney, ureter, renal, pelvic, urinary, bladder and breast cancers in that order as well," says Dennis J. Ahnen, MD, CU Cancer Center investigator and professor of gastroenterology at the Denver VA Medical Center, one of the paper's co-authors.

The research group, which includes member from six centers, used data from 127 women included in the Colon Cancer Family Registry (CCFR). Ahnen notes that the CCFR is unique among cancer registries in that it not only collects information on patients with colorectal cancer and their treatment outcomes, but also routinely performs molecular characterization of these tumors, which can show which of these cancers are associated with Lynch Syndrome or other genetic abnormalities. Importantly, this molecular categorization allows researchers to discover which of the three possible pathways led to a patient's cancer the traditional chromosomal instability pathway accounts for about 80 percent of all colorectal cancers, and Lynch Syndrome combines with an epigenetic pathway to account for the remaining 20 percent.

"Knowing a cancer's genetic makeup all
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Worried Well Often Ignore Negative Test Results: Study
2. Mothers Drinking Increases Risk of Infants Death: Study
3. Soccer Kicks Up Activity Level of Overweight Kids: Study
4. Gene Disorder Screen Benefits Baby Boys, Girls Equally: Study
5. Cleveland Clinic study shows bariatric surgery restores pancreatic function by targeting belly fat
6. Another Study Says Mediterranean Diet Good for the Heart
7. C-Section May Raise Childs Risk of Allergies, Asthma: Study
8. Teen Pregnancy-Prevention Program Works, Study Says
9. Study reveals stem cells in a human parasite
10. Climate Change May Threaten Worker Health, Productivity, Study Says
11. Without Laws, Many Tanning Salons Would Allow Kids: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... ― A new study in the American Journal ... Google searches reveals a recurring pattern that could be ... Investigators from San Diego State University, the Santa Fe ... "healthy" Google searches (searches that included the term healthy ... the U.S. from 2005 to 2012. They found that ...
(Date:4/17/2014)... variant specifically associated with the risk of a ... cent of all breast cancer cases. , The ... called invasive lobular carcinoma, gives researchers important clues ... of breast cancer, which can be missed through ... the journal PloS Genetics , was co-led ...
(Date:4/17/2014)... Researchers at the University of California, San Diego School ... those who have suffered a recent major loss are ... older adults. , The study is published in this ... Psychiatry . , Because compassionate behaviors are associated with ... findings offer insights into ways to improve the outcomes ...
(Date:4/17/2014)... 2014U.S. military personnel who served in Iraq and ... brain injury (TBI) were compared to military personnel ... reasons. Differences in measures of overall disability, cognitive ... injury are reported in an article in ... Mary Ann Liebert, Inc., publishers. The article is ...
(Date:4/17/2014)... By discovering a new mechanism that allows blood ... at UC Irvine and the Salk Institute have opened ... prevent stroke-induced brain damage. , A complex and devastating ... and primary reason for disability in the U.S. The ... lets blood-borne material into the brain, causing the permanent ...
Breaking Medicine News(10 mins):Health News:New research shows people are thinking about their health early in the week 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:The ilk of human kindness 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:Study IDs new cause of brain bleeding immediately after stroke 2
... 19 (HealthDay News) -- A heart characteristic linked to ... non-athletes, and black male athletes are much more likely ... study finds. The characteristic -- left-ventricular hyper-trabeculation (LVHT) ... (chronic disease of the heart muscle). The abnormality is ...
... THURSDAY, April 19 (HealthDay News) -- Magnetically controlled growing ... without the need for repeat invasive surgeries, a small ... of the spine that occurs mainly in young children ... growing is surgical insertion of growing rods. Every six ...
... ,New research findings show how it may be possible to render ... the body. The findings apply to cancers including breast, lung and ... Sweden. Many of the most common chemotherapy drugs used to ... the cells in the cancer tumour, but also the cells in ...
... Anti-tobacco television advertising helps reduce adult smoking, according to a ... Institute for Health Research and Policy -- but some ads ... are exposed to a variety of anti-smoking messages on television. ... produced by various sponsors, impact adult smoking behaviors, or on ...
... shortfall in funding for emergency laparotomies in England and have ... picture of outcomes and costs. Figures published in the May ... million per year for emergency midline general surgical laparotomies, 32% ... also found that emergency laparotomy, which involves a large midline ...
... This press release is available in ... with thousands of local teenagers by University of Montreal ... ecstasy (MDMA) at fifteen or sixteen years of age ... the following year. "Our findings are consistent with other ...
Cached Medicine News:Health News:Study Pinpoints New Abnormality in 'Athlete's Heart' 2Health News:Scoliosis Treatment Might Reduce Need for Surgeries 2Health News:Possible new cancer treatment identified 2Health News:Anti-tobacco TV ads help adults stop smoking, study finds 2Health News:Study reveals major funding shortfall and high death rates for emergency laparotomy 2Health News:Study reveals major funding shortfall and high death rates for emergency laparotomy 3Health News:Speed and ecstasy associated with depression in teenagers 2
(Date:1/15/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) ... approval condition to the announced tender offer for all of the ... a result of the waiver, the transaction is no longer conditional ... on January 24, 2014 following the currently scheduled expiration time, subject ...
(Date:1/15/2014)... is very pleased to announce the appointment of Mr. ... Mark was promoted from his current role of Chief Operating ... in Massachusetts , Mississippi ... 2012 with 20+ years of broad-based operations, sales, engineering and ...
(Date:1/15/2014)... 2014 Reportlinker.com announces that a new ... catalogue: Insulin Pump ... http://www.reportlinker.com/p01957812/Insulin-Pump-Market--Forecast-–-Worldwide-Analysis.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Equipment_and_Supply ... Insulin Pumps are gaining strong acceptance ...
Breaking Medicine Technology:Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17
... Triiodothyronine (T3) is produced primarily by ... Within the thyroid gland, T3 production occurs ... than that for T4. Release of T3 ... is ~5-8 micrograms/day as compared to 80-100 ...
... Human Insulin-like growth factor binding protein-3 (IGFBP-3) is ... in postnatal serum, as a component of the ... IGFBP-3, a molecule of IGF-I or IGF-II and ... the actions of the IGFs. The molar concentration ...
... a monomeric protein produced and stored in ... is released from the pituitary into the ... regulatory control of hypothalamic somatostatin (SS) and ... frequency of GH release appears to be ...
... is a monomeric protein produced and stored ... GH is released from the pituitary into ... the regulatory control of hypothalamic somatostatin (SS) ... and frequency of GH release appears to ...
Medicine Products: