Navigation Links
Study reveals that chemotherapy works in an unexpected way
Date:4/4/2013

It's generally thought that anticancer chemotherapies work like antibiotics do, by directly killing off what's harmful. But new research published online on April 4 in the Cell Press journal Immunity shows that effective chemotherapies actually work by mobilizing the body's own immune cells to fight cancer. Researchers found that chemo-treated dying tumors secrete a factor that attracts certain immune cells, which then ingest tumor proteins and present them on their surfaces as alert signals that an invader is present. This new understanding of how chemotherapy works with our immune systems could prompt new tactics for treating cancer.

"Successful chemotherapeutics convert the tumor into a therapeutic vaccine, hence mobilizing the host's immune system against the cancer," explains senior author Dr. Guido Kroemer, of the Institut Gustave Roussy, in France.

Dr. Kroemer and his colleagues found that when chemotherapy kills and bursts open cancer cells, the cells release a factor called ATP. The factor recruits immune cells to the tumor site, where they are educated to acquire their functionnamely, to ingest and present tumor proteins on their surfaces. The researchers found that when these trained immune cells are blocked, chemotherapy (specifically, anthracyclines) cannot efficiently reduce the growth of tumors in mice. Also, when these trained immune cells are injected into other mice, the mice can fight off cancer cells that are subsequently injected.

The findings point to a new strategy to improve cancer treatments. "Anticancer therapies and immunotherapies might be combined in a way to optimize the local recruitment and function of immune cellsfor instance, by increasing extracellular ATP levelswith the goal of boosting the chemotherapy-induced anticancer immune response," says Dr. Kroemer. Also, measuring the recruitment of immune cells to tumor sites after chemotherapy might help predict how well a patient's cancer will respond to the treatment.


'/>"/>
Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. Balding Men Could Face Higher Heart Risks, Study Finds
2. U.S. Spends More on Dementia Care Than Heart Disease or Cancer: Study
3. Prostate cancer treatment study changing the way doctors practice
4. Dementia costs top those for heart disease or cancer, study finds
5. Nutralife Hails New Study’s Findings on SAM-e, Giving Hope to Millions Seeking Joint Relief
6. Low Testosterone Linked to Later Arthritis in Study
7. Black Men Often Face Delays in Prostate Cancer Care: Study
8. Laser Therapy Switches Cocaine Addiction On, Off in Rats: Study
9. NIH study sheds light on how to reset the addicted brain
10. Multiple factors predict repeat suicide-related behavior in youth: Study
11. Competitive Cash-for-Weight-Loss Plans Work Best: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2017)... ... April 26, 2017 , ... Bioclinica® ... sponsors and CROs to speed clinical development, has released the industry’s only ... Bioclinica AGILE RTSM provides seamless clinical supply forecasting and management together ...
(Date:4/25/2017)... KY (PRWEB) , ... April 25, 2017 , ... ... announce they have signed an agreement to be the preferred physical therapy provider ... injuries and returning them to Derby City CrossFit as quickly and effectively as ...
(Date:4/25/2017)... ... April 25, 2017 , ... A recent report from the ... for the 2015-16 school year across Wisconsin’s public schools, charter schools, and private ... patterns in student test score performance, the report’s limited analyses fail to provide ...
(Date:4/25/2017)... ... 2017 , ... As pharmaceutical companies are held to increasingly ... innovation in drug formulation and manufacturing. CoreRx offers its clients more than ... support of their development and manufacturing goals. , The company was created ...
(Date:4/25/2017)... Scotch Plains, NJ (PRWEB) , ... April 25, 2017 , ... Saad B. Chaudhary, MD ... with the treatment of acute or chronic problems, I focus on preventative care with all ... patient. If you have any questions, always feel free to contact my office and my ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... April 19, 2017 Global Surgical Drainage Device ... tubes used to remove excess liquid and air. The ... urine, bile or lymph. Surgical drains are used in ... as orthopedics surgery, cardiovascular surgery, neurosurgery, plastic surgery etc. ... to prevent accumulation of fluid e.g. blood or pus. ...
(Date:4/19/2017)... 19, 2017  Sorrento Therapeutics, Inc. (NASDAQ: ... company developing new treatments for cancer and other ... its previously announced underwritten public offering of 23,625,084 ... offering price of $2.00 per share, before deducting ... payable by Sorrento.  The net proceeds to Sorrento ...
(Date:4/19/2017)... , April 19, 2017  SARES•REGIS Group ... it is developing at Conejo Spectrum Business Park ... to Atara Biotherapeutics, Inc. , a biopharmaceutical ... and life-threatening diseases that have been underserved by ... T-cell therapies for cancer, autoimmune and infectious disease. ...
Breaking Medicine Technology: