Navigation Links
Study reveals protective role for specialized cells in intestinal and respiratory systems
Date:7/7/2014

RIVERSIDE, Calif. Ripping a page from the Star Trek script, specialized cells of the barrier that lines the inside of the intestines and airways of humans have invoked a biological version of Captain Kirk's famous command "shields up" as a first defense against invading microbes.

Research in the UCR School of Medicine laboratory of David Lo found that certain cells of the epithelium have a potentially important role in immune surveillance creating an electrostatic repulsion field to microbial invasion.

The study is featured on the cover of the July issue of Infection and Immunity, a journal published by the American Society for Microbiology. Co-authors of the study are Kaila M. Bennett, one of Lo's graduate students, and Sharon L. Walker, a UCR professor of chemical and environmental engineering.

The finding improves scientists' understanding of the densely packed protrusions resembling a carpet on the surface of some cells that line the insides of the intestines and respiratory system. The protrusions, which biologists call microvilli, increase the surface area of cells and have a role in absorbing nutrients, for instance.

But Lo's laboratory has found that the microvilli actually repel negatively charged bacteria and viruses, suggesting a protective "shield" akin to the force field that envelops the Enterprise in the plots of many "Star Trek" television episodes and movies.

"This is a whole new way of looking at immune surveillance in the epithelium of the human gut and airway," said Lo, a distinguished professor in the medical school's Division of Biomedical Sciences. "If we can take advantage of this electrostatic repulsion, it could improve the diagnosis and treatment of certain bacterial infections."

A number of bacterial and viral infections can gain a foothold in the human body through adsorption via the intestines and airways, such as Salmonella and the flu.

Lo's laboratory has for more than a dozen years studied immune responses in the gut and airways, focusing particularly on cells which function as an early warning in the immune system. "We study the role of certain epithelial cells in the immune system. By understanding how the immune system is able to capture and carry viruses and bacteria across this barrier to trigger a protective immune, we may be able to design better synthetic vaccines, including needle-free vaccines," Lo said.

Lo joined UCR in 2006. In addition to his faculty position in the UCR School of Medicine Division of Biomedical Sciences, he is affiliated with the UCR Center for Disease Vector Research and the UC Global Health Institute. He is a fellow of the American Association for the Advancement of Sciences (2007) and a 2005 recipient of a "Grand Challenges in Global Health" award, Bill and Melinda Gates Foundation and the Foundation for the National Institutes of Health.


'/>"/>

Contact: Kathy Barton
kathryn.barton@ucr.edu
951-827-4598
University of California - Riverside
Source:Eurekalert  

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study reveals protective role for specialized cells in intestinal and respiratory systems
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: