Navigation Links
Study reveals protective role for specialized cells in intestinal and respiratory systems
Date:7/7/2014

RIVERSIDE, Calif. Ripping a page from the Star Trek script, specialized cells of the barrier that lines the inside of the intestines and airways of humans have invoked a biological version of Captain Kirk's famous command "shields up" as a first defense against invading microbes.

Research in the UCR School of Medicine laboratory of David Lo found that certain cells of the epithelium have a potentially important role in immune surveillance creating an electrostatic repulsion field to microbial invasion.

The study is featured on the cover of the July issue of Infection and Immunity, a journal published by the American Society for Microbiology. Co-authors of the study are Kaila M. Bennett, one of Lo's graduate students, and Sharon L. Walker, a UCR professor of chemical and environmental engineering.

The finding improves scientists' understanding of the densely packed protrusions resembling a carpet on the surface of some cells that line the insides of the intestines and respiratory system. The protrusions, which biologists call microvilli, increase the surface area of cells and have a role in absorbing nutrients, for instance.

But Lo's laboratory has found that the microvilli actually repel negatively charged bacteria and viruses, suggesting a protective "shield" akin to the force field that envelops the Enterprise in the plots of many "Star Trek" television episodes and movies.

"This is a whole new way of looking at immune surveillance in the epithelium of the human gut and airway," said Lo, a distinguished professor in the medical school's Division of Biomedical Sciences. "If we can take advantage of this electrostatic repulsion, it could improve the diagnosis and treatment of certain bacterial infections."

A number of bacterial and viral infections can gain a foothold in the human body through adsorption via the intestines and airways, such as Salmonella and the flu.

Lo's laboratory has for more than a dozen years studied immune responses in the gut and airways, focusing particularly on cells which function as an early warning in the immune system. "We study the role of certain epithelial cells in the immune system. By understanding how the immune system is able to capture and carry viruses and bacteria across this barrier to trigger a protective immune, we may be able to design better synthetic vaccines, including needle-free vaccines," Lo said.

Lo joined UCR in 2006. In addition to his faculty position in the UCR School of Medicine Division of Biomedical Sciences, he is affiliated with the UCR Center for Disease Vector Research and the UC Global Health Institute. He is a fellow of the American Association for the Advancement of Sciences (2007) and a 2005 recipient of a "Grand Challenges in Global Health" award, Bill and Melinda Gates Foundation and the Foundation for the National Institutes of Health.


'/>"/>

Contact: Kathy Barton
kathryn.barton@ucr.edu
951-827-4598
University of California - Riverside
Source:Eurekalert  

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study reveals protective role for specialized cells in intestinal and respiratory systems
(Date:12/7/2016)... ... 07, 2016 , ... Facial plastic surgeon, Dr. John D. Rachel of ... of proceeds to two local organizations: North Chicago Animal Control and Friends and Our ... a team of authorized and trained volunteers who support rescued animals held in the ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... Dallas, Texas, is condemning "scam operations" carried out by unethical locksmith companies and ... scam operations to a halt. According to Texas Premier Locksmith, these fraudulent locksmith ...
(Date:12/7/2016)... CA (PRWEB) , ... December 07, 2016 , ... The ... the holidays and winter seasons. One major study analyzing heart attacks among 138,602 ... to August of a given year. We would all agree of course–no time of ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... 2016 BOC Business Brilliance Awards under the Best New Product Launch category. Gensuite’s ... achieved through user experience. , BOC Global Events & Training Group is a ...
(Date:12/7/2016)... ... December 07, 2016 , ... Maureen ... Program at Reproductive Medicine Associates of Connecticut (RMACT). McLaughlin brings nearly 20 years ... three acupuncturists to help patients realize their family building goals. Acupuncture helps ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... -- KEY FINDINGS Patient warming and ... loss of blood during surgeries, lowering the risks ... after surgeries, and decreasing risks of SSIs. The ... warming system, surface warming systems, and intravascular warming ... at hospitals thus, lowering the healthcare costs by ...
(Date:12/7/2016)... 7, 2016 Research and Markets has announced ... User - Global Forecast to 2021" report to their offering. ... , , ... by 2021, growing at a CAGR of 7.3% during the forecast period ... prevalence of cancer and rapidly increasing geriatric population across the globe are ...
(Date:12/7/2016)... Dec. 7, 2016 DelveInsight,s, "Janus ... provides in depth insights on the pipeline ... Janus Kinase 3 (JAK3) Inhibitors. The DelveInsight,s ... stages of development including Discovery, Pre-clinical, IND, ... Preregistration. Report covers the product clinical trials ...
Breaking Medicine Technology: