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Study reveals possible link between IBD therapy and skin cancer
Date:10/29/2009

ed OR 4.04). In particular, persistent use of the thiopurine class was strongly associated with NMSC (adjusted OR 4.27). Persistent use of biologic medications in patients with Crohn's disease was also associated with NMSC (adjusted OR 2.18).

"The increased risk of NMSC in patients with IBD is likely related to the immunosuppressive medications used to treat the disease, although we can't rule out changes to the immune system itself as a result of IBD as contributing to this risk," explains Dr. Long who led the study. "In patients on immunosuppression therapy after organ transplant, previous studies have shown a clear association with NMSC. Other studies have demonstrated that azathioprine, which is in the thiopurine class, can increase the photosensitization of human skin."

"Our study demonstrates that patients with IBD on immunosupression may also be at risk for NMSC. As a result, our long term management plans for IBD patients should stress the daily use of broad-spectrum sunscreen and increased awareness of NMSC to help to prevent complications," concludes Dr. Long.


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Contact: Jennifer Burke Labriola
burkepr@gmail.com
203-405-1479
American College of Gastroenterology
Source:Eurekalert

Page: 1 2

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