Navigation Links
Study reveals new metabolic safeguards against tumor cells
Date:8/19/2009

s in laboratory cell culture. They also emphasize that the experiments were not designed to mimic the effect of dietary antioxidants in the body. The researchers used two specific antioxidant compoundswhich are chemically distinct from those found in food and supplementsonly in order to understand how oxidants contributed to the metabolic defects.

"We think that genes with antioxidant activity play a much bigger role than antioxidant compounds administered from outside the body," says Brugge. "What happens with dietary antioxidants is much more complicated and not what we were trying to study."

Beyond cell suicide

The researchers had previously reported that when cells were endowed with a cancer-causing gene that prevents them from committing suicide, they still died when cut off from their extracellular environment. This puzzled researchers, who have long thought that apoptosis was the only way the cells could die.

In the recent study, Schafer and colleagues took a closer look, measuring the levels of proteins and molecules associated with metabolic activity in the displaced, but apoptosis-resistant, cells. They found that the cells had become incapable of taking up glucose, their primary energy source. Under the microscope, the cells also displayed telltale signs of oxidative stress, a harmful accumulation of oxygen-derived molecules called reactive oxygen species (ROS). The end result was a halt in the production of ATP, the molecular lifeblood that transports energy in the cells. The unmoored cells were literally starving to death.

"The idea that a lack of extracellular matrix can prevent cells from accessing nutrients hasn't been shown conclusively before," says Schafer. "Loss of glucose transport, decreased ATP production, increased oxidative stressall those things turn out to be interrelated."

To figure out what was wrong, the researchers took a straightforward approachthey tried to fix it. Schafer
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Nonprofit nursing homes provide better care, major study finds
2. Longitudinal study investigates cocaines impact on adolescent development
3. Study finds adverse effects in treatment for primary sclerosing cholangitis
4. Study shows carvedilol is effective in preventing variceal bleeding in cirrhotic patients
5. Profiles International Releases New Study Identifying Key Factors for Strategic Workforce Planning
6. Thomson Reuters Study Finds Impact of Recession Easing on U.S. Hospitals
7. Retirees health-care benefits at risk, study warns
8. Lilly Reports on Outcome of Phase III Study of Arzoxifene
9. New study finds links between video-game playing and health risks in adults
10. Gen-Probe Begins U.S. Clinical Study of APTIMA(R) Trichomonas Vaginalis Assay on the TIGRIS(R) System
11. Study shows how to boost value of Alzheimers-fighting compounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Anterior Cruciate Ligament (ACL) reconstructions occur more ... material used to create a new ligament may determine ... presenting their work today at the Annual Meeting of ... ). , “Our study results highlight that ... a donor) fail more frequently than using autografts (tissue ...
(Date:7/11/2014)... Re-tearing a repaired knee Anterior Cruciate Ligament (ACL) ... presented today at the American Orthopaedic Society for Sports ... education regarding modifiable risk factors may minimize the chance ... suggests that a few risk factors such as, age, ... to the possibility of re-injury," said lead author, Christopher ...
(Date:7/11/2014)... 11, 2014 With the maturity and ... on comfort, the installation rate of Chinese car electric ... installation rate exceeded 88% and the demand outnumbered 75 ... next few years, Chinese car electric window regulator market ... the market size is expected to exceed 110 million ...
(Date:7/11/2014)... 2014 Wild by Nature, a natural and ... they are opening a fifth store to be located in ... one of the largest selections of wheat and gluten-free products ... disease, these stores have become a one-stop shop for anyone ... sensitivity, and gluten intolerance, is a spectrum of disorders, including ...
(Date:7/11/2014)... July 11, 2014 B. E. Smith, the ... has been retained to lead a national chief nursing ... in Bend, Ore. The top executive search firm ... more than 900 healthcare executives into organizations. , With ... Charles Health System is the largest provider of medical care ...
Breaking Medicine News(10 mins):Health News:ACL Reconstructions May Last Longer With Autografts 2Health News:China Car Electric Window Regulator Industry to Grow at CAGR of 10% to 2017 Says a New Research Report at ChinaMarketResearchReports.com 2Health News:China Car Electric Window Regulator Industry to Grow at CAGR of 10% to 2017 Says a New Research Report at ChinaMarketResearchReports.com 3Health News:China Car Electric Window Regulator Industry to Grow at CAGR of 10% to 2017 Says a New Research Report at ChinaMarketResearchReports.com 4Health News:Wild by Nature Opens New Location 2Health News:St. Charles Health System Retains B. E. Smith to Recruit New CNO 2Health News:St. Charles Health System Retains B. E. Smith to Recruit New CNO 3
... Million Grant to Support In-depth, Explanatory Reporting , ... time of uncertainty and transition in the news media, the ... a unique partnership with the California HealthCare Foundation (CHCF) to ... , , Funded by a three-year ...
... , , Practice Abuses ... Group , , WASHINGTON, Sept. 17 ... the bureaucratic abuse of insured patients by for-profit insurance companies, Consumer ... about their use of employees to lobby Congress on company time. ...
... Obama ,plan, as transparent as a Cheney cabinet meeting, says Norquist ... spoke at length about what he called "my plan" before a joint session of Congress. ... several days. By our count he has mentioned the "plan": , , ... of Congress on Sept. 9 , 6 ...
... , , , ... Med" or the "Company") (OTC Bulletin Board: GLOB), an international healthcare ... Med,s Chairman and CEO, will make a major new product announcement ... will be held at The Embassy Suites Boca Raton Hotel, Boca ...
... , Award recognizes local initiatives that ... CHICAGO, Sept. 17 YMCA of the USA today announced ... Casey Foundation FAMILIES COUNT Family Strengthening Award in recognition of their exemplary ... , This is the fourth year that YMCA of the ...
... , DALLAS, Sept. 17 Prostate cancer is the ... in six men being diagnosed with the disease in their lifetime. ... as a strong advocate for prostate cancer awareness, Kimberly-Clark and its ... End Prostate Cancer to help educate men on the risks associated ...
Cached Medicine News:Health News:USC Annenberg and California HealthCare Foundation Join in New Health Care Journalism Venture 2Health News:USC Annenberg and California HealthCare Foundation Join in New Health Care Journalism Venture 3Health News:Consumer Watchdog Says Insurers Must Answer Questions About Use of Employees as Mini-Lobbyists in Congress 2Health News:Where is President Obama's Health Care 'Plan'? 2Health News:Global Med Technologies, Inc.'s CEO to Make Major New Product Announcement the Morning of the LDV Investor Conference and Will Demo the Product on Wednesday, September 23, 2009 2Health News:Global Med Technologies, Inc.'s CEO to Make Major New Product Announcement the Morning of the LDV Investor Conference and Will Demo the Product on Wednesday, September 23, 2009 3Health News:YMCA of the USA and Annie E. Casey Foundation Honor Five YMCAs for Family Strengthening Excellence 2Health News:YMCA of the USA and Annie E. Casey Foundation Honor Five YMCAs for Family Strengthening Excellence 3Health News:YMCA of the USA and Annie E. Casey Foundation Honor Five YMCAs for Family Strengthening Excellence 4Health News:YMCA of the USA and Annie E. Casey Foundation Honor Five YMCAs for Family Strengthening Excellence 5Health News:Video: 'The Depend Campaign to End Prostate Cancer' Brings Sports Legends Together to Celebrate National Prostate Cancer Awareness Month 2
(Date:1/15/2014)... 2014 Most osteoporosis patients want a choice in ... survey* sponsored by Mission Pharmacal Company. The survey, conducted ... online support community, revealed that 74 percent of osteoporosis ... a form other than a pill or a tablet. ...
(Date:1/15/2014)... today announced it has established a relief fund ... that has gripped much of the nation. AARP and its ... support these emergency relief efforts AARP and AARP Foundation will ... to $500,000 in aid. The matching program will be administered ...
(Date:1/15/2014)... 15, 2014 Massachusetts General Hospital (MGH), the ... ) announced today that they have launched a ... therapeutic targets and develop novel therapies for inflammatory ... millions worldwide. The MGH-Broad-Amgen collaboration brings together scientists ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4
... Encouraging Response in CF Patients - Results Validate ... March 27 The Cystic Fibrosis Foundation,announced today that ... defect in CF, showed promising results in an ongoing ... mutation of CF. The drug is,being developed by Vertex ...
... Research Associates, LLC,announced today that it has issued ... Inc. (TSX: BNC). The full 68-page report,can be ... a Canadian biopharmaceutical company that is committed to,improving ... animals worldwide through,innovative research, novel technologies, and therapeutics. ...
Cached Medicine Technology:Cystic Fibrosis Foundation Announces Positive Early Results for Phase 2 Clinical Trial of VX-770 - an Oral Compound to Treat CF 2Cystic Fibrosis Foundation Announces Positive Early Results for Phase 2 Clinical Trial of VX-770 - an Oral Compound to Treat CF 3Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Bioniche Life Sciences Inc. 2Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Bioniche Life Sciences Inc. 3
... Plate is a semi-rigid system intended ... The Slim-LOC is based on the ... current market technology. The Slim-LOCTM system ... instrumentation. Reduced width (16 mm), low ...
... SC-Acufix anterior cervical plate system is a ... integrated swivel, which provides for consistent, reliable ... bone screw disengagement or backout. This innovative ... locking screw. Simply implant your screws and ...
... a leading provider of telemedicine solutions. ... state-of-the-art technology deliver accurate, reliable and ... professionals and clients in improving outcomes. ... ECG technology to gather patient data, ...
... is a high performance temperature controlled shaker ... shaking speed and incubation time are fully ... parameters are displayed on the LCD in ... below the microplates provide uniform incubation with ...
Medicine Products: