Navigation Links
Study reveals new metabolic safeguards against tumor cells
Date:8/19/2009

s in laboratory cell culture. They also emphasize that the experiments were not designed to mimic the effect of dietary antioxidants in the body. The researchers used two specific antioxidant compoundswhich are chemically distinct from those found in food and supplementsonly in order to understand how oxidants contributed to the metabolic defects.

"We think that genes with antioxidant activity play a much bigger role than antioxidant compounds administered from outside the body," says Brugge. "What happens with dietary antioxidants is much more complicated and not what we were trying to study."

Beyond cell suicide

The researchers had previously reported that when cells were endowed with a cancer-causing gene that prevents them from committing suicide, they still died when cut off from their extracellular environment. This puzzled researchers, who have long thought that apoptosis was the only way the cells could die.

In the recent study, Schafer and colleagues took a closer look, measuring the levels of proteins and molecules associated with metabolic activity in the displaced, but apoptosis-resistant, cells. They found that the cells had become incapable of taking up glucose, their primary energy source. Under the microscope, the cells also displayed telltale signs of oxidative stress, a harmful accumulation of oxygen-derived molecules called reactive oxygen species (ROS). The end result was a halt in the production of ATP, the molecular lifeblood that transports energy in the cells. The unmoored cells were literally starving to death.

"The idea that a lack of extracellular matrix can prevent cells from accessing nutrients hasn't been shown conclusively before," says Schafer. "Loss of glucose transport, decreased ATP production, increased oxidative stressall those things turn out to be interrelated."

To figure out what was wrong, the researchers took a straightforward approachthey tried to fix it. Schafer
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Nonprofit nursing homes provide better care, major study finds
2. Longitudinal study investigates cocaines impact on adolescent development
3. Study finds adverse effects in treatment for primary sclerosing cholangitis
4. Study shows carvedilol is effective in preventing variceal bleeding in cirrhotic patients
5. Profiles International Releases New Study Identifying Key Factors for Strategic Workforce Planning
6. Thomson Reuters Study Finds Impact of Recession Easing on U.S. Hospitals
7. Retirees health-care benefits at risk, study warns
8. Lilly Reports on Outcome of Phase III Study of Arzoxifene
9. New study finds links between video-game playing and health risks in adults
10. Gen-Probe Begins U.S. Clinical Study of APTIMA(R) Trichomonas Vaginalis Assay on the TIGRIS(R) System
11. Study shows how to boost value of Alzheimers-fighting compounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... Beat Eczema , Susan Clark’s ... natural methods to completely cure the eczema symptoms they ... Shane Michaels, prompting an investigative review. , “Although ... it can still be extremely debilitating and life-altering for ... itching and pain that it causes on the skin ...
(Date:8/22/2014)... the first time an oncogenic somatic mutation at amino ... has been identified in small cell lung cancer (SCLC) ... cell lines produced increased intracellular signaling and cell growth. ... cancer representing 15% of all lung cancers and is ... lung cancer, has been extensively examined for genomic alterations ...
(Date:8/22/2014)... August 22, 2014 Paying tuition and ... in the coming year for four nurse educators pursuing ... National League for Nursing Foundation for Nursing Education . ... share $28,000, $10,000 more than in 2013, thanks to ... Endowment and Elizabeth Isaac Marcil Endowment Funds, both donated ...
(Date:8/22/2014)... New York, New York (PRWEB) August 22, 2014 ... ) continue to be filed in U.S. courts ... cardiovascular events due to their use of prescription ... to court documents, a new claim was filed ... California man who allegedly suffered life-threatening heart issues ...
(Date:8/22/2014)... 2014 CarePoint Health is proud ... Medicine, Geriatrics, Hospice and Palliative Care, Dr. Michelle ... Group. Their system welcomes Dr. Reisner to the ... comprise CarePoint Health Medical Group, a comprehensive network ... representing a wide range of specialties. This latest ...
Breaking Medicine News(10 mins):Health News:Beat Eczema: Review Exposes Susan Clark’s Guide to Curing Eczema Naturally 2Health News:Novel oncogenic RET mutation found in small cell lung cancer 2Health News:NLN Foundation for Nursing Education Announces 2014 Faculty Scholarship Awards 2Health News:NLN Foundation for Nursing Education Announces 2014 Faculty Scholarship Awards 3Health News:Testosterone Treatment Lawsuit News: New Filing Alleges Depo-Testosterone Caused Life-Threatening Heart Problems, Bernstein Liebhard LLP reports. 2Health News:Testosterone Treatment Lawsuit News: New Filing Alleges Depo-Testosterone Caused Life-Threatening Heart Problems, Bernstein Liebhard LLP reports. 3Health News:Testosterone Treatment Lawsuit News: New Filing Alleges Depo-Testosterone Caused Life-Threatening Heart Problems, Bernstein Liebhard LLP reports. 4Health News:Dr. Reisner Joins CarePoint Health Medical Group 2
... HARRISBURG, Pa. , Jan. 18 Be active to ... Department of Health are conveying to middle school-aged children throughout the ... statewide program kicks off locally at 1:30 p.m. Wednesday, Jan. ... Steelton-Highspire Middle School is an Active Schools grant recipient. ...
... with affect your behavior, for good or bad, research ... you spend time with people who exhibit self-control -- ... instance -- you can expect your own self-control to ... But the opposite seems true, too: Spending time with ...
... KNOXVILLE, Tenn. , Jan. 18 Remote Area Medical®, ... countries and in the U.S., announced today that it will be ... earthquake relief efforts at the Jimani Project facility in Jimani, ... Brock and RAM volunteers loaded more than a ton of ...
... during female ovulation, study finds , MONDAY, Jan. ... a man,s attention shouldn,t wear perfume, new research suggests. ... and Jon K. Maner found that male testosterone levels ... during ovulation, which is when women are most fertile. ...
... Renée ... Health. , ... Heights, N.J. (Vocus) January 18, 2010 -- Renée Schreiber Chervenak, M.D., has recently joined ... Chervenak earned her B.A. summa cum laude at Boston University College of Engineering and ...
... ... osteoporosis everyday because of common misconceptions about the disease. Dr. Karl R.O.S. Johnson, D.C. describes ... osteoporosis - without dangerous medications. , ... (PRWEB) January 18, 2010 -- The National Osteoporosis Foundation in the United States has ...
Cached Medicine News:Health News:Capital BlueCross Partners with Department of Health, Area Schools to Encourage Students to Lead Active, Healthy Lifestyles 2Health News:Capital BlueCross Partners with Department of Health, Area Schools to Encourage Students to Lead Active, Healthy Lifestyles 3Health News:Self-Control Just Might Be Contagious 2Health News:Self-Control Just Might Be Contagious 3Health News:Remote Area Medical Travels to Haiti to Assist in Earthquake Relief Efforts 2Health News:Remote Area Medical Travels to Haiti to Assist in Earthquake Relief Efforts 3Health News:Summit Medical Group Welcomes Rene Schreiber Chervenak, M.D. 2Health News:Medical Breakthrough: Drug Free Strategy Shows Promise for Reversing or Halting Osteoporosis for Michigan Men and Women 2
(Date:8/22/2014)... Aug. 22, 2014 MC Medical, a subsidiary of ... Columbus, OH medical device company, have ... laparoscopic and robotic visualization system in Japan ... sale in Japan in the latter ... and an extensive product portfolio in endoscopic surgery market in ...
(Date:8/22/2014)... 22, 2014 Research and Markets ... Chinese Particulate Respirators Industry Report 2014" report to ... Particulate Respirators Industry Report 2014 is a professional and ... particulate respirators industry with a focus on the Chinese ... the industry including definitions, classifications, applications and industry chain ...
(Date:8/22/2014)... August 22, 2014 ... Today Lincor announced general availability of ... that delivers a range of education, entertainment and clinical ...      (Logo: http://photos.prnewswire.com/prnh/20140822/702945) , " ... of care patient engagement to bedside smart devices, " ...
Breaking Medicine Technology:MC Medical agrees to be the exclusive distributor of FloShield products in Japan 2Global and Chinese Particulate Respirators Industry Report 2014 2Lincor Unveils Next Generation TV-based Patient Engagement Solution 2
... April 10, 2012 /PRNewswire-Asia/ -- China Botanic Pharmaceutical ... Botanic" or the "Company"), a developer, manufacturer and ... medicines ("TCM") in China, today announced the results ... Meeting") held on Tuesday, April 10, 2012 (Beijing ...
... Mylan Inc. (Nasdaq: MYL ) announced today that ... Thursday, April 26, 2012, at 10:00 a.m. ET, to review ... ended March 31, 2012. Mylan will release its financial results ... dial-in number to access the call is 877.402.3913 or 817.382.5964 ...
Cached Medicine Technology:China Botanic Announces Results of Annual General Meeting 2