Navigation Links
Study reveals insights that could aid in therapeutic use of mesenchymal stem cells
Date:11/15/2012

MSC uses hydrostatic pressure to create a bulge or bleb in the cell's outer membrane that exerts mechanical force against the endothelium, leading to the initial break in its barrier that initiates transmigration. "We demonstrated that MSCs can transmigrate between endothelial cellscalled paracellular transmigrationand directly through a single endothelial cellcalled transcellular migration," says Karp. "This is an exciting finding as it provides a new axis that potentially can be modulated for developing next-generation MSC therapy." During transcelluar migration, an MSC doesn't actually enter an endothelial cell, but rather forms a pore through which it then migrates.

Interestingly, say the researchers, these findings may also provide insights on how some tumor cells spread or metastasize, as migratory blebbing has been observed in a number of embryonic germ cells and in some tumor cells. "Our finding shows for the first time that blebbing may function in the critical barrier-breaching event of MSC migration through endothelial cells," says Carman. "This suggests that blebs could similarly function in cancer invasiveness."

For now, however, Carman and his colleagues will focus on MSCs. Among their next steps is to verify that the results generated in the lab hold true within the body. "From there, we wish to iterate back and forth between our in vitro and in vivo systems to explore a range of bioengineering approaches that build on the new knowledge from this study to design improved delivery and efficacy of MSC therapeutics," says Carman, adding that as the understanding of the mechanisms of MSC movement grows, researchers' abilities to enhance homing to specific tissues through engineered approaches should help bring MSC therapy closer to the clinic.


'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... TherapySites, the leading website ... today its affiliation with the Illinois Association for ... allows TherapySites to continue to extend their online marketing ... offers. , “There has been a fundamental shift in ... nearly 3 billion Internet users, it is so important ...
(Date:7/28/2014)... July 28, 2014 Footwear etc. is ... styles from Mephisto. With shoes, sandals, and boots that ... products continually provide handmade comfort shoes and ... women have come to rely on the superb value, ... Mephisto shoes and sandals contain the highest quality materials ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 To commemorate ... Editorial Board of Living with a Disability magazine ... disabling digestive disorders that include hepatitis, gastrointestinal hemorrhage, inflammatory ... , The important new article highlights that, in the ... afflicted with hepatitis and other disabling conditions related to ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 According to the ... a comprehensive relationship guide that helps women easily get the ... , Vkool reveals in its review that this book ... eyes of their man. The book also instructs them how ... Vkool informs in its Drama Method review that this book ...
(Date:7/28/2014)... Suwanee, GA (PRWEB) July 28, 2014 ... across the nation gathered at the MGE Management Experts ... officials and community leaders joined the Dentists to raise ... of the Boys and Girls Clubs and Youth Programs ... thousands of young people with books and audio books ...
Breaking Medicine News(10 mins):Health News:TherapySites (Websites for Therapists) Partners with the Illinois Association for Marriage and Family Therapy 2Health News:Footwear etc. Highlights Phenomenal Models of Mephisto Shoes 2Health News:Footwear etc. Highlights Phenomenal Models of Mephisto Shoes 3Health News:Living with a Disability Magazine Marks World Hepatitis Day on July 28 with New Article on Disabling Digestive Disorders 2Health News:Living with a Disability Magazine Marks World Hepatitis Day on July 28 with New Article on Disabling Digestive Disorders 3Health News:The Drama Method Pdf Review Exposes Aaron Fox's Relationship Guide – Vkool.com 2Health News:The Drama Method Pdf Review Exposes Aaron Fox's Relationship Guide – Vkool.com 3Health News:Mitul R. Patel, DDS Successfully Attacks a Major Source of Economic Destruction in the Battle Against Illiteracy and Poverty 2Health News:Mitul R. Patel, DDS Successfully Attacks a Major Source of Economic Destruction in the Battle Against Illiteracy and Poverty 3
... a new study from the Journal of Bone and ... fasciitis who perform manual plantar fasciitis stretching exercises, as opposed ... Study details and findings: , A ... were randomly assigned to two groups. Acute is defined ...
... Nov. 3 (HealthDay News) -- Friendly discussions with other people ... are competitive in tone aren,t helpful, finds a new study. ... the way you do when you,re making friends, can provide ... at the Institute for Social Research at the University of ...
... a new clinical practice guideline for the nutritional and ... with diabetes mellitus. The guideline features a series of ... The guideline is published in the November 2010 issue ... ( JCEM ), a publication of The Endocrine ...
... HealthDay Reporter , WEDNESDAY, Nov. 3 (HealthDay News) ... treatment for men with prostate cancer, use declined drastically. ... -- androgen-deprivation therapy -- still received it, researchers report in ... of Medicine . "Probably what we,re witnessing here is ...
... CINCINNATIResearchers at the University of Cincinnati (UC) and the Cincinnati ... of chronic kidney disease patients who are prescribed therapies for ... This report was published in the Nov. 2 online edition ... study, led by researchers at UC and the Cincinnati VA, ...
... Stereotactic body radiotherapy (SBRT), a radiation therapy procedure pioneered ... precisely delivers a large dose of radiation to tumors, ... when combined with the chemotherapy Cetuximab, according to researchers ... presented today at the American Society for Radiation Oncology ...
Cached Medicine News:Health News:Plantar fasciitis? Stretching seems to do the trick 2Health News:Good Conversation Can Boost Brain Power, Study Finds 2Health News:Experts issue recommendations for treatment of post-bariatric surgery patients 2Health News:Use of Prostate Cancer Treatment Fell When Medicare Paid Docs Less 2Health News:Use of Prostate Cancer Treatment Fell When Medicare Paid Docs Less 3Health News:Medication adherence improves blood pressure control in chronic kidney disease 2Health News:Combining radiation therapy, chemotherapy safely treats head and neck cancer patients 2
(Date:7/25/2014)... , July 25, 2014 Leading events ... is returning for the seventh year to São Paulo, ... th August 2014. The event will co-locate with Food ... most comprehensive meeting point for the pharmaceutical industry. ... 25 countries for pharmaceutical sales are now exploring the ...
(Date:7/25/2014)... Dr. Michael Gabriel of a prominent Staten ... study, which shows how grief in pregnancy may cause obesity ... According to US News , "Unborn children ... others to grow up overweight or obese, even if that ... specific types of stress that caused obesity: "Children whose biological ...
(Date:7/24/2014)... July 24, 2014  PTC Therapeutics, Inc. (NASDAQ: ... host a webcast conference call to report its second ... the company,s business and outlook on Thursday, August 7, ... the market. The call can be ... (international) five minutes prior to the start of the ...
Breaking Medicine Technology:CPhI South America 2014 Launches with Generics Showing Huge Growth 2CPhI South America 2014 Launches with Generics Showing Huge Growth 3CPhI South America 2014 Launches with Generics Showing Huge Growth 4Dr. Michael Gabriel of GPM Pediatrics, a Noted Staten Island Pediatrics Clinic, Comments on Study, Which Names Grief as a Cause of Obesity in Children 2
... Inc. joined the National Senior Games Association to launch the ... a global leader in musculoskeletal health, Zimmer is proud to ... athletic achievements of 356 athletes assembled for this year,s winter ... year,s games as they demonstrate what can be achieved by ...
... Sysmex America, Inc., a global leader in ... today announces the release of the newest version ... The Sysmex WAM Management Reports Module features new ... enable the user to quickly develop on-demand reports, ...
Cached Medicine Technology:Zimmer Sponsors Winter National Senior Games 2Sysmex Announces Newest Version of Clinical Laboratory Management Software 2
... and balanced for smooth, one-handed control. Reflexion's ... reducing fatigue in even the longest procedures. ... to easily steer the catheter through its ... finger. Reflexion's auto-lock technology keeps the catheter ...
... technologies - Quantum™ LEAP® balloon material ... unite in the Quantum™ Maverick® Balloon ... force balloon with exceptional deliverability. Easier ... shaft technology improves trackability and crossability ...
... Libert Coronary Stent System ... of lesion access and ... a low crossing profile, ... catheter, the performance of ...
... colonies, rows, and microplatesthat is the area ... is becoming an ever-increasing force. Ergonomics (reduced ... main reason that the Multichannel Research model ... pipette provides effective, precise, and rapid processing ...
Medicine Products: