Navigation Links
Study reveals insights that could aid in therapeutic use of mesenchymal stem cells
Date:11/15/2012

MSC uses hydrostatic pressure to create a bulge or bleb in the cell's outer membrane that exerts mechanical force against the endothelium, leading to the initial break in its barrier that initiates transmigration. "We demonstrated that MSCs can transmigrate between endothelial cellscalled paracellular transmigrationand directly through a single endothelial cellcalled transcellular migration," says Karp. "This is an exciting finding as it provides a new axis that potentially can be modulated for developing next-generation MSC therapy." During transcelluar migration, an MSC doesn't actually enter an endothelial cell, but rather forms a pore through which it then migrates.

Interestingly, say the researchers, these findings may also provide insights on how some tumor cells spread or metastasize, as migratory blebbing has been observed in a number of embryonic germ cells and in some tumor cells. "Our finding shows for the first time that blebbing may function in the critical barrier-breaching event of MSC migration through endothelial cells," says Carman. "This suggests that blebs could similarly function in cancer invasiveness."

For now, however, Carman and his colleagues will focus on MSCs. Among their next steps is to verify that the results generated in the lab hold true within the body. "From there, we wish to iterate back and forth between our in vitro and in vivo systems to explore a range of bioengineering approaches that build on the new knowledge from this study to design improved delivery and efficacy of MSC therapeutics," says Carman, adding that as the understanding of the mechanisms of MSC movement grows, researchers' abilities to enhance homing to specific tissues through engineered approaches should help bring MSC therapy closer to the clinic.


'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... ... August 01, 2015 , ... Calvary Hospital today announced that it is ... campus. The goal is to bring this Torah – dating from 1880 – back ... and religious services. , Scroll No. 515, from the town of Taus-Domazlice, is ...
(Date:8/1/2015)... ... August 01, 2015 , ... Brig and Lita Hart, icons of the network ... their Healthy Home mission with the HOPE Movement of EvolvHealth. In what has been ... companies have agreed to join their missions of purpose together to change the course ...
(Date:8/1/2015)... , ... August 01, 2015 , ... On Tuesday, July ... , who are thought to have been behind the attack on Anthem Inc. which ... were zero day exploits, watering hole attacks and spear phishing campaigns. , ...
(Date:8/1/2015)... ... August 01, 2015 , ... BeverlyD, owner and founder of BeverlyD Luxe ... the very first small business donation to kick off the campaign for healing and ... Her legacy includes a complete line of raw, organic hair care products, as well ...
(Date:8/1/2015)... ... August 01, 2015 , ... On March 19, 2015 Phil Valentine – the Executive Director of ... Appalachian Trail by stepping off Springer Mountain and heading north. Since that day, Phil ... reached Connecticut and was greeted by friends and family. He visited CCAR and left ...
Breaking Medicine News(10 mins):Health News:Calvary Hospital Announces Plans to Restore Historic Torah 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 3Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 2Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 4Health News:March4thforWellBeing Foundation Kickoff 2Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2
... begun full-parity plans ahead of deadline; new case studies ... reports the majority of its customers are revamping their ... Act, and that a significant amount already have gone ... 1, 2010. ComPsych Corporation is the world,s largest provider ...
... University of Leeds are working on a new type of body ... cement with recycled carbon fibre materials to make a material tough ... project, still at the early research stage, is being carried out ... Philip Purnell, who is leading the team, said: "By using cement ...
... Improves Patient Care with Automatic Access to Radiology Reports ... a division of Conceptual MindWorks, Inc. (CMI), today announced ... Radiological Association,s (ARA) radiology reports. ARA is one of ... operates 14 outpatient radiology clinics in addition to providing ...
... Innovative new concept caters to active baby-boomer retirees , ... of America (ORCA) has started taking reservations for a program ... private residential cruise ship that also provides both the Independent ... , "People retire to Florida for three things mainly ...
... , CHICAGO, June 29 Rising Financial ... of Rising Medical Solutions, Inc., is pleased to announce ... Business Development for its Medicare Set Aside (MSA) Administration ... , , Abdelsayed joins Rising Financial Solutions (Rising) ...
... , Italy, June 29 Health-Robotics today announced,that ... with Grifols,S.A., the leading Pharmacy Automation provider in ... accurately, and cost-effectively automate,the preparation of non-hazardous IV ... this strategic partnership, Grifols will take,delivery of 120 ...
Cached Medicine News:Health News:Mental Health Parity Act Spurs Early Action Among Employers 2Health News:Sevocity Launches EHR (Electronic Health Record) Interface With Austin Radiological Association 2Health News:Sevocity Launches EHR (Electronic Health Record) Interface With Austin Radiological Association 3Health News:Retirement Cruise Ship Nearing Launch 2Health News:Rising Financial Solutions Taps Director of Business Development for Medicare Set Aside Administration Offerings 2Health News:Health Robotics Announces i.v.STATION(TM) Contract With Grifols in Spain, Portugal and South America 2Health News:Health Robotics Announces i.v.STATION(TM) Contract With Grifols in Spain, Portugal and South America 3
(Date:7/30/2015)... Ohio , July 30, 2015  Cleveland Clinic ... OMTEC® 2015 keynote address last month that industry is ... in order to gain the efficiencies—and develop the transformational ... Dr. Barsoum,s comments were preceded by Doug ... entrepreneur and OMTEC moderator, who stressed that industry must ...
(Date:7/30/2015)... , July 30, 2015  Growth of the ... as they bring former prescription users to the OTC ... Kline forecasts robust Rx-to-OTC switch activity over the ... emerging along with many new brands entering the market ... over the next five years (even those with low ...
(Date:7/30/2015)... 2015 P&S Market ... market overview, trends, DRO analysis, market segmentation, ... developments, competitive scenario and top competitor profiles ... Market Development and Demand Forecast to 2020  ... Explore more about global biosensors ...
Breaking Medicine Technology:Orthopaedic Surgery Reimbursement Shifts to Episode of Care 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 3Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 2Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 3Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 4Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 5
... , WOONSOCKET, R.I., Oct. 15 CVS/pharmacy announced today ... October 22, in light of manufacturer delays in delivery ... However, MinuteClinic will continue to administer seasonal flu ... the flu season with the supply of vaccine replenished ...
... Cynosure, Inc. (Nasdaq: CYNO ... of light-based aesthetic treatment systems, today announced that the company ... 27, 2009 at 9:00 a.m. ET. , On the call, ... President and Chief Financial Officer Timothy Baker will discuss Cynosure,s ...
Cached Medicine Technology:CVS Caremark Announces Updates to Flu Vaccine Program 2CVS Caremark Announces Updates to Flu Vaccine Program 3Cynosure to Announce Third-Quarter 2009 Financial Results on October 27 2
... Nephew ECTRA II systems permit the surgeon ... ligament endoscopically, allowing access via two portals ... endoscopic lens fogging with good air flow. ... and control. ECTRA knives permit the surgeon ...
... Screw System provides a unique option for the ... particularly the opening wedge osteotomy of the first ... Fragment Plate and Screw Set is a complete ... houses the plates, screws, and drills. It provides ...
Micro instruments designed to provide maximum grasping, resecting capability, and excellent maneuverability for easy access to tight, small joints (wrist, elbow, and ankle).,Features pinless hinge d...
Micro instruments designed to provide maximum grasping, resecting capability, and excellent maneuverability for easy access to tight, small joints (wrist, elbow, and ankle).,Features pinless hinge d...
Medicine Products: