Navigation Links
Study reveals how normal cells fuel tumor growth
Date:12/21/2011

Research summary:

  • The study shows how normal cells in tumors can enhance the growth of the tumor's cancer cells after losing an important tumor suppressor gene called Pten.

  • The findings suggest a new strategy for treating breast cancer by interrupting signals between normal cells and cancer cells in tumors.

    COLUMBUS, Ohio A new study published in the journal Nature Cell Biology has discovered how normal cells in tumors can fuel tumor growth.

    Led by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James), the study examines what happens when normal cells called fibroblasts in mouse mammary tumors lose an important tumor-suppressor gene called Pten (pronounced "P ten").

    The findings suggest new strategies for controlling tumor growth by developing drugs that disrupt the communication between tumor cells and the normal cells within the tumor. They also provide insight into the mechanisms that control the co-evolution of cancer cells and surrounding normal cells in tumors, and they demonstrate how the Pten gene normally suppresses cancer development, the researchers say.

    "Our study is the first to define a specific pathway in tumor fibroblasts that reprograms gene activity and the behavior of multiple cell types in the tumor microenvironment, including tumor cells themselves," says co-principal investigator Dr. Michael Ostrowski, professor and chair of molecular and cellular biochemistry.

    "Along with increasing basic knowledge about how tumors grow and spread, these findings have direct translational implications for the treatment of breast-cancer patients," says Ostrowski, who is a member of the OSUCCC James Molecular Biology and Cancer Genetics program.

    The researchers found that Pten regulates a molecule called microRNA-320 (miR-320), and that the loss of Pten leads to a dramatic drop in levels of
    '/>"/>


  • Contact: Darrell E. Ward
    Darrell.Ward@osumc.edu
    614-293-3737
    Ohio State University Medical Center
    Source:Eurekalert

    Page: 1 2 3

    Related medicine news :

    1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
    2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
    3. TV drama can be more persuasive than news program, study finds
    4. Study carried out into biological risks of eating reptiles
    5. Neuroimaging study may pave way for effective Alzheimers treatments
    6. Study finds racial gaps continue in heart disease awareness
    7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
    8. First blinded study of venous insufficiency prevalence in MS shows promising results
    9. Soothing infants with food focus of childhood obesity study
    10. People with anxiety disorder less able to regulate response to negative emotions, study shows
    11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:9/15/2014)... (PRWEB) September 15, 2014 (PRWEB) September 15, 2014 ... not; what the startup business requirements are in each ... new business. , Speakers include industry professionals, such as ... Center in Oakland,CA and cannabis business consultant ... who are already successfully running legal marijuana businesses all ...
    (Date:9/15/2014)... Concox , a leading designer and manufacturer of ... to bringing reliable products and customized solutions to clients ... products, GT06N not only looks appealing but has many ... and original GPS car and truck tracker with an ... on cars or trucks. , Concox has already introduced ...
    (Date:9/14/2014)... St. Louis, MO (PRWEB) September 14, 2014 ... events can now use the Quotes Pros website to ... portal that was constructed this year at http://quotespros.com/life-insurance.html ... , The insurance company partners that are preparing ... this year are located in most U.S. states. As ...
    (Date:9/14/2014)... 14, 2014 Proper oral care requires ... Butte, Mont., found a way to teach children to ... B LITE toothbrush encourages an effective brushing habit by ... two minutes without overbrushing, eliminating guesswork and promoting independence ... to use, suitable for all children, and producible in ...
    (Date:9/14/2014)... Getting enough sleep each night may mean you,re less likely to ... suggests. The study included more than 3,700 people in Finland, ... seven years. Those who slept less than six hours or ... have extended absences from work due to illness, the investigators found. ... due to sickness were those who slept between seven and eight ...
    Breaking Medicine News(10 mins):Health News:How to Start And Run a Successful Legal Marijuana Business 2Health News:iConcox GPS Vehicle Tracker GT06N Designed for Customers' Security 2Health News:Quotes for Life Insurance Now Offered at New Consumer Portal Online 2Health News:A Good Night's Sleep May Mean a Good Day's Work 2
    ... , , FRANKLIN ... (NYSE: MHS ), the world,s most advanced pharmacy(R) ... into a joint venture with United Drug plc, a Pan-European healthcare ... for patients covered by the country,s National Health Service (NHS). ...
    ... , MARINA DEL RAY, Calif., Aug. 12 Dr. ... to welcome Italian students from the University of L,Aquila by assisting ... school is being rebuilt after the devastating April 5th earthquake in ... who were displaced by the earthquake in L,Aquila, Italy, including the ...
    ... ISELIN, N.J., Aug. 12 Pharmos Corporation (Pink Sheets: PARS) today reported financial ... , Second Quarter Ended June 30, 2009 , ... or $0.05 per share, for the second quarter 2009 compared to a net ... Cash and cash equivalents totaled $2.9 million at June 30, 2009. , ...
    ... have given for years , WEDNESDAY, Aug. 12 (HealthDay News) ... painful swelling of the arm that often occurs after breast ... to what women have been told for years -- that ... other exercise because muscle strain can cause lymphedema to worsen. ...
    ... Goal is to help patients who might benefit from ... By clarifying rules governing patient access to so-called investigational ... to expand the number of people who might benefit ... can get the drugs hasn,t changed, but there is ...
    ... , WASHINGTON, Aug. 12 During a town ... stated his opposition to legislation that would cover illegal aliens. Specter ... was the author of the 2006 amnesty bill (S. 2611) that ... illegal aliens under the proposed reforms is a clear indication of ...
    Cached Medicine News:Health News:Medco Health Solutions, United Drug Announce U.K. Homecare Pharmacy Joint Venture Serving Patients with Chronic and Complex Health Conditions; Innovations to Improve Clinical Quality, Reduce Costs 2Health News:Medco Health Solutions, United Drug Announce U.K. Homecare Pharmacy Joint Venture Serving Patients with Chronic and Complex Health Conditions; Innovations to Improve Clinical Quality, Reduce Costs 3Health News:Heritage Provider Network and Dr. Richard Merkin Come to the Aid of Italian Earthquake Victims 2Health News:Heritage Provider Network and Dr. Richard Merkin Come to the Aid of Italian Earthquake Victims 3Health News:Pharmos Corporation Reports 2009 Second Quarter Results 2Health News:Pharmos Corporation Reports 2009 Second Quarter Results 3Health News:Pharmos Corporation Reports 2009 Second Quarter Results 4Health News:Pharmos Corporation Reports 2009 Second Quarter Results 5Health News:Pharmos Corporation Reports 2009 Second Quarter Results 6Health News:Pharmos Corporation Reports 2009 Second Quarter Results 7Health News:Pharmos Corporation Reports 2009 Second Quarter Results 8Health News:Pharmos Corporation Reports 2009 Second Quarter Results 9Health News:Weight Lifting Can Ease Arm Swelling in Breast Cancer Survivors 2Health News:Weight Lifting Can Ease Arm Swelling in Breast Cancer Survivors 3Health News:FDA Details Access to 'Investigational' Drugs 2Health News:FDA Details Access to 'Investigational' Drugs 3Health News:Specter Promises to Oppose Health Care Reform That Covers Illegal Aliens 2
    (Date:9/12/2014)... Mass. , Sept. 12, 2014  Royal Philips ... a number of innovations at ASTRO,s 56th Annual ... showcasing solutions that increase workflow automation, confidence, consistency and ... time and enhancing patient-centric care, these radiation oncology solutions ... of a more personalized approach to medicine. ...
    (Date:9/12/2014)... -- WellStar Paulding Hospital is the first hospital in ... the U.S. to offer a new, innovative procedure to ... Paulding Hospital is on the cutting edge of medical ... Inspire Therapy offers relief for moderate to severe ... use traditional treatments, like Continuous Positive Airway Pressure (CPAP). ...
    (Date:9/12/2014)... September 12, 2014 According to ... (Glucose Monitoring & Infectious Diseases Testing Kits, Cardiac & ... Over the Counter & Prescription Based - Global Forecast ... POC Diagnostics Market over the forecast period of 2013 ... a CAGR of 9.3% from 2013 to 2018, to ...
    Breaking Medicine Technology:Philips Demonstrates Commitment to Radiation Oncology Solutions at ASTRO 2014 2Philips Demonstrates Commitment to Radiation Oncology Solutions at ASTRO 2014 3WellStar Pioneers New Sleep Apnea Treatment 2Point-Of-Care Diagnostic Market Worth $27.5 Billion by 2018 2Point-Of-Care Diagnostic Market Worth $27.5 Billion by 2018 3Point-Of-Care Diagnostic Market Worth $27.5 Billion by 2018 4
    ... Neb., May 15 Creighton Medical Laboratories, based at ... announced today that it has become the first clinical ... testing method for cancer. The method, called SNP array ... to study cancer for several years. However, Creighton Medical ...
    ... Case Demonstrating RenalGuard To Be PresentedFRANKLIN, Mass., May ... PLCSF), a company focused on innovative cardiac and ... will demonstrate its RenalGuard System(TM) at EuroPCR, the ... Cardiovascular Interventions (EAPCI), May 19-22, 2009, in Barcelona, ...
    Cached Medicine Technology:Creighton Medical Laboratories First to Offer New Cancer Test 2Creighton Medical Laboratories First to Offer New Cancer Test 3PLC Medical Systems to Demonstrate RenalGuard(R) at EuroPCR 2009 2PLC Medical Systems to Demonstrate RenalGuard(R) at EuroPCR 2009 3PLC Medical Systems to Demonstrate RenalGuard(R) at EuroPCR 2009 4
    ... Detect™ IgM Capture ELISA is for the ... WNV recombinant antigens (WNRA) in serum as ... of West Nile virus infection in patients ... results must be confirmed by Plaque Reduction ...
    Adult; dilates 6.0 to 34.0 French; individually packaged, sterile....
    The removable inflation adapter allows the ureteroscope to be removed after the catheter is in place. Supplied sterile in peel-open packages. Intended for one-time use....
    The removable inflation/injection adapter allows the cystoscope to be removed after the catheter is in place. Supplied sterile in peel-open packages. Intended for one-time use....
    Medicine Products: