Navigation Links
Study reveals details of alternative splicing circuitry that promotes cancer's Warburg effect
Date:11/2/2011

Cold Spring Harbor, N.Y. Cancer cells maintain their life-style of extremely rapid growth and proliferation thanks to an enzyme called PK-M2 (pyruvate kinase M2) that alters the cells' ability to metabolize glucose a phenomenon known as the Warburg effect.

Professor Adrian Krainer, Ph.D., and his team at Cold Spring Harbor Laboratory (CSHL), who seek to reverse this effect and force cancer cells to regain the metabolism of normal cells, have discovered details of molecular events that cause cancer cells to produce PK-M2 instead of its harmless counterpart, an isoform called PK-M1. Their study, performed in collaboration with Professor Lewis Cantley, Ph.D., and his colleagues at Harvard Medical School and The Koch Institute, in Cambridge, Mass, appears on November 1 in the Journal of Molecular Cell Biology.

Both protein isoformsPK-M2 and PK-M1, the latter of which is found only in normal cellsare both encoded by the same gene, PK-M, in a mutually exclusive fashion via a process called alternative splicing. After the gene is transcribed to produce RNA, unneeded bits called introns are first spliced out. How the remaining bits, called exons, are stitched back together by the cell's splicing machinery decides which protein version is produced. In the case of the RNA transcript for PK-M RNA, the choice is between two exons: exon 9, found in PK-M1; and exon 10, whose inclusion results in PK-M2 production.

"In this study, our goal was to determine what exactly the splicing machinery looks for when it's trying to decide which exon to include and which exon to exclude," specifies Krainer. Following a series of experiments in which the team manipulated the two exons within a precursor form of the RNA PK-M by duplicating them, swapping their positions, etc., the scientists discovered that the signals for mutually exclusive splicing reside within the two exons themselves.

The exon 10-inclusion signal is a potent splicing "enh
'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Exenatide (Byetta) has rapid, powerful anti-inflammatory effect, UB study shows
2. Cancer Risk Doubles After Organ Transplant, Study Finds
3. Yoga Gets Women With Back Pain Moving: Study
4. Study finds overweight teens want to lose weight, going about it the wrong way
5. Many radiologists disagree on management of incidental findings, study finds
6. Handheld Metal Detectors Dont Seem to Affect Pacemakers: Study
7. Study shows no increased risk of breast cancer for non-carriers in families with BRCA gene mutation
8. The freshman 15 is just a myth, nationwide study reveals
9. First-of-its-kind study creates new tool for targeted cancer drug development
10. Study finds community counseling reduced the prevalence of TB on a budget
11. Practice Doesnt Always Make Perfect, Study Suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... May 23, 2013 Footwear etc. is pleased ... Vista Collection of sandals containing cork footbeds. Known for its ... consistently good sales for many years, and with this new ... summer. , Dansko Shoes and Sandals are ... Collection is no exception. Containing leather and patent leather uppers ...
(Date:5/23/2013)... 2013 Long-Term Care Insurance shopping ... rate at which applicants for Long Term Care Insurance are ... , The decision to buy a Long Term Care ... willing and able to purchase protection are increasingly being turned ... any price. A variety of chronic conditions appear to ...
(Date:5/23/2013)... 2013 AttorneyOne.com, a recognized authority on ... actively providing expert opinion in view of the recent ... According to court documents, on March 5, 2013 a ... (case no. 3:2013cv50102) alleging that her husband suffered massive ... Pharmaceuticals, is mainly used as a blood thinner for ...
(Date:5/22/2013)... 23, 2013 Most women dread cellulite ... several factors, including estrogen being a factor in the ... fatty deposits stored and smashed together which create that ... must take a multi-pronged action," says Kathy Heshelow, founder ... Specific products like Cellulite Whisperer ® that work ...
(Date:5/22/2013)... Existing research shows that bicyclists who wear helmets have ... researchers at Boston Children,s Hospital found that simply having ... decrease in deaths and injuries for children younger than ... , The cross-sectional study, conducted by William P. Meehan ... Mannix, MD, MPH of Boston Children,s Hospital, and Christopher ...
Breaking Medicine News(10 mins):Health News:Footwear etc. Announces the New Collection of Dansko Cork Sandals 2Health News:More Baby Boomers Rejected by Long Term Care Insurance Companies 2Health News:More Baby Boomers Rejected by Long Term Care Insurance Companies 3Health News:New Lawsuit on Pradaxa Brain Hemorrhage: Now, AttorneyOne Can Provide Advice 2Health News:Get Cellulite Under Control Now with Cellulite Whisperer® Products Introduced by Sublime Beauty® 2Health News:Rate of bicycle-related fatalities significantly lower in states with helmet laws 2
... for combating prostate cancer was developed by researchers of ... received the Barenholz Prize for Creativity and Originality in ... its donor, Yehezkel Barenholz, the Dr. Daniel G. Miller ... School, was presented recently during the 70th meeting of ...
... a novel way of increasing stem cells in blood, ... bone marrow transplant. ,The recent research ... to help patients bounce back sooner after treatment for ... is available in detail in the current issue of ...
... the link between levels of urate in the blood and ... of Public Health (HSPH) have found that high levels of ... disease. ,Urate is a normal component of ... might also have beneficial effects because it is a potent ...
... world's leading wine producer, has fostered just one revolution in ... The slow pace of change has been offset however by ... that in Britain -- sometimes called the "scourge of the ... ,Holding back innovations in both French packaging and branding has ...
... Bush administration proposal was met with opposition as Children's ... the proposal will limit the eligibility of low-income families ... Children's Health Insurance Program. ,The families who ... to the policy debate on the floor of Congress. ...
... Governments measures to address Indigenous child abuse, initially in the ... the AMA to play the key role in addressing this ... that the AMA is seeking a briefing from the Prime ... the proposals so work can commence as soon as practicable. ...
Cached Medicine News:Health News:Novel Method to Inhibit Prostate Cancer 2Health News:Fishing for a Speedy Recovery After Chemotherapy or Marrow Transplant 2Health News:Fishing for a Speedy Recovery After Chemotherapy or Marrow Transplant 3Health News:Urate Reduces the Risk of Parkinsons Disease 2Health News:Wine Packaging: Bag-in-box, Plastic Bottles, Cork Comeback? 2Health News:Wine Packaging: Bag-in-box, Plastic Bottles, Cork Comeback? 3Health News:Childrens Health Program Covering More Adults Than Children 2Health News:Childrens Health Program Covering More Adults Than Children 3Health News:Indigenous Child Abuse 2
(Date:5/22/2013)... , May 22, 2013  Modern Medical ... Manager™ (ODM).  Launched in November 2012 in a ... care program to stop the rising opioid abuse ... proactive, customized program designed to protect employees, physicians ... maintaining the necessary balance to provide pain relief ...
(Date:5/22/2013)... 2013 STEPh, Inc., a full service medical ... their web site ( http://www.stephreports.com ) dedicated ... About STEPh Reports STEPh Reports are comprehensive ... Each STEPh Report assesses the competitive landscape by individual ... company, and specific key issues.  STEPh Reports are written ...
(Date:5/22/2013)... -- MEDIFIRST SOLUTIONS, INC. (OTCQB: MFST) would like to ... company developments. As Medifirst continues to expand its business, ... Integrating social media into its investor relations strategy, the ... updates on Twitter.  The Facebook homepage is Medifirst Solutions ... Says CEO Bruce J. Schoengood , ...
Breaking Medicine Technology:Modern Medical Introduces Opioid Abuse Solution to the Workers' Compensation Industry 2Scientific and Technical Evaluation of Pharmaceuticals, Inc. [STEPh, Inc.], Launches New Competitive Intelligence Web Site 2Medifirst Solutions, Inc. Announces Update To Shareholders 2
... , , ... OPTR ) today announced that new data highlighting ... vancomycin-resistant enterococci (VRE) acquisition from Optimer,s North American phase 3 ... Antimicrobial Agents and Chemotherapy (ICAAC) in San Francisco. , ...
... HONG KONG, Sept. 15 Data from multiple clinical trials ... stent, and preclinical data from Combo Bio-engineered Sirolimus Eluting Stent ... symposium, TCT 2009, in San Francisco. , , ... Center in Amsterdam will provide the final 12-month outcomes from ...
Cached Medicine Technology:Optimer Announces Presentation of Additional Data From Fidaxomicin Phase 3 Study for the Treatment of Clostridium Difficile Infection (CDI) 2Optimer Announces Presentation of Additional Data From Fidaxomicin Phase 3 Study for the Treatment of Clostridium Difficile Infection (CDI) 3Optimer Announces Presentation of Additional Data From Fidaxomicin Phase 3 Study for the Treatment of Clostridium Difficile Infection (CDI) 4Optimer Announces Presentation of Additional Data From Fidaxomicin Phase 3 Study for the Treatment of Clostridium Difficile Infection (CDI) 5Optimer Announces Presentation of Additional Data From Fidaxomicin Phase 3 Study for the Treatment of Clostridium Difficile Infection (CDI) 6Data From Multiple Clinical Trials of OrbusNeich's Genous(TM) Bio-engineered R stent(TM) to be Presented at TCT 2009 2Data From Multiple Clinical Trials of OrbusNeich's Genous(TM) Bio-engineered R stent(TM) to be Presented at TCT 2009 3
Disposable Cannula Cuffless Tracheostomy Tubes...
... KIMBERLY-CLARK BALLARD Adult TRACH ... to take place at the ... Available in T-Piece, Double Swivel ... Features dual lavage/irrigation port. Offers ...
... KIMBERLY-CLARK BALLARD Adult TRACH CARE ... T-Piece, Elbow and Double Swivel ... from vials; 12 vials per ... multiple tracheostomy sizes, French sizes ...
... BALLARD Adult TRACH CARE ... endotracheal intubated patients. Rounded ... provide smooth surface interface. ... locking thumb port. Offers ...
Medicine Products: