Navigation Links
Study reveals current multi-component vaccines may need reworking
Date:5/7/2009

, many modern vaccines introduce detoxified versions of disease-related molecules to the immune system, which remembers them for next time. Once researchers confirm the kind of immune response needed to achieve protection, they can choose for inclusion in a multi-component vaccine the key peptides that trigger the strongest immune response. The immune system reacts, not to the presence of a whole bacterium or virus, but instead to key fragments of those pathogens.

Peptide-based vaccines are already used clinically in cancer, and researchers have made progress determining the specific peptides on the surface of bacteria, viruses and tumors that trigger T cell responses. Oftentimes, vaccine designers will seek to determine several peptides that elicit T cell responses and mix them together to assure greater immune protection. The assumption was that mixing components, each known to elicit a strong T cell response, together would make for a stronger vaccine.

Working in Sant's Lab, Jason Weaver conducted experiments that revealed that including several pathogenic peptides, each known cause a T cell response in isolation, may not be additive when injected into the same dendritic cell. In fact, some of the peptides may cancel out the ability of others to cause T cell expansion because of immunodominance.

Vaccine designers in the future may have to inject the several peptides in multi-component vaccines into different regions of the body so that the strong peptides do not cancel out the weak, researchers said. A second solution may be to change cryptic or weak peptide vaccine components into immunodominant ones. Sant and members of her laboratory including Francisco Chaves, Christopher Lazarski and Weaver have already shown that by switching out single amino acid building blocks, the team was able to drastically increase the potency of the T cell response to target peptides, including those that would otherwise fail to achieve a T cell respon
'/>"/>

Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. UIC receives $1M HUD grant to study green healthy housing
2. PEAK Surgical Announces Positive Fascia Incision Healing Results From Preclinical Study of PEAK PlasmaBlade(TM) for Gynecologic Surgery
3. New study reveals the financial effects of stroke in China
4. Study Finds That Patients With Excessive Sweating Condition Are More Likely to Develop Skin Infections
5. Study in pregnant women suggests probiotics may help ward off obesity
6. No Safe Bets for Casino Workers: NIOSH Study Shows Casino Workers Face Toxic Conditions
7. SCAI Statement on A National Study of the Effect of Individual Proton Pump Inhibitors on Cardiovascular Outcomes in Patients Treated with Clopidogrel Following Coronary Stenting: The Clopidogrel Medco Outcomes Study
8. NIH multicenter AIDS cohort study commemorates 25 years of discovery
9. Pitt study on alcohol reveals drinkers not only zone out -- but also are unaware that they do
10. ABCs and No Skinned Knees: Study Reveals Various Barriers to Physical Activity in Child Care
11. Large Study of Lacrisert(R) Dry Eye Insert:
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... CA (PRWEB) , ... August 27, 2015 , ... ... plans to enter the exploding legal marijuana industry with the launch of its ... consumers of legal marijuana to order products from their smart phones and tablets. ...
(Date:8/27/2015)... ... August 27, 2015 , ... About 10 percent of ... the Gulf Coast, killing more than 1,800 people, displacing hundreds of thousands and ... State University study. , While most people don’t develop persistent depression after a ...
(Date:8/27/2015)... ... ... The Naderi Center is proud to announce that its own Dr. ... submental fat. The first and only Food and Drug Administration (FDA) approved treatment ... the only Board Certified surgeon in the D.C., Maryland, Virginia area to offer this ...
(Date:8/27/2015)... Yardley, Penn. (PRWEB) , ... August 27, 2015 ... ... engagement solutions, confirmed today that its Krames Patient Education content is ICD-10 ready ... and is ready for the new ICD-10 code sets, which are more targeted ...
(Date:8/27/2015)... ... August 27, 2015 , ... Zensah®, ... Glushko, professional Tennis player for Israel in the Women’s Tennis Association (WTA). Glushko ... her training and recovery. , With a focus on technology and comfort, Zensah® ...
Breaking Medicine News(10 mins):Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 2Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 3Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 4Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 5Health News:About 10 Percent of Mothers Experienced Depression Two Years After Hurricane Katrina, New Study Shows 2Health News:Noninvasive Double Chin Elimination Now Available in Herndon and Chevy Chase 2Health News:Noninvasive Double Chin Elimination Now Available in Herndon and Chevy Chase 3Health News:StayWell announces all health content is ICD-10 ready 2Health News:StayWell announces all health content is ICD-10 ready 3Health News:Zensah® Compression Announces Partnership with WTA Tennis Professional Athlete, Julia Glushko 2Health News:Zensah® Compression Announces Partnership with WTA Tennis Professional Athlete, Julia Glushko 3
... cell startlingly similar to its human counterpart will likely ... organ tissue in people, two studies reported Wednesday. ... the inner-most layer of week-old rodent embryos, will provide ... diseases and injuries, the researchers said. ,"They ...
... Czech authorities said Wednesday the H5N1 virus, which is potentially lethal ... its recent discovery among wild birds in Germany. ... farm near the village of Norin, just four kilometers (2.5 miles) ... after the virus was detected there. ,The farm in ...
... the world, but the situation remains critical in Egypt and ... a major human threat remains high, the UN health ... countries in Asia, Eastern Europe and the Middle East where ... it was rapidly detected and eliminated or controlled," said Joseph ...
... Saing Ratha lies semi-conscious, her thin body shaking with fever as ... ice under her arms. ,Her 10-year-old bother Saing ... in this spartan rural clinic. ,Both have been struck ... in the first six months of this year as during the ...
... Ever dreamed of being drawn close to a smiling Marilyn ... ,A Japanese firm on Wednesday unveiled a ... of three-dimensional images using a sensor-loaded glove. ,The ... of a screen and has a glove that allows users ...
... authorities and United Nations agencies said Thursday they will immunise ... in history. ,The virulent disease is one ... the lives of 58 children a day, but vaccination coverage ... the largest immunization campaign in the world. I think it ...
Cached Medicine News:Health News:'Missing Link' Stem Cells may Shorten Path to Therapies 2Health News:'Missing Link' Stem Cells may Shorten Path to Therapies 3Health News:Potentially Lethal H5N1 Bird Flu Resurfaces in Europe 2Health News:Bird Flu Risk Still Running High in Egypt, Indonesia, WHO Says 2Health News:Dengue Deaths Sweeping Cambodia Highlight Healthcare Failures 2Health News:Dengue Deaths Sweeping Cambodia Highlight Healthcare Failures 3Health News:Pakistan to Launch World's Biggest Anti-measles Drive 2
(Date:8/26/2015)... PUNE, India , August 27, 2015 ... market research reports reviewing the genotyping technology, ... as well as single nucleotide polymorphism (SNP) ... ReportsnReports.com. Complete report on genotyping ... spread across 200 pages, profiling 10 major ...
(Date:8/26/2015)... NEW YORK , Aug. 26, 2015 ... estimated to witness a CAGR of 7.8% during the ... North American ophthalmology cataract surgery devices market in 2014 ... North American ophthalmology cataract surgery devices market is expected ... owing to the increasing strategic expansion of the companies ...
(Date:8/26/2015)... 2015 Edwards Lifesciences Corporation (NYSE: EW ... valves and hemodynamic monitoring, today announced that it has ... privately held company and developer of a transcatheter mitral ... had signed an agreement to acquire CardiAQ. ... $350 million cash for CardiAQ at closing, with an ...
Breaking Medicine Technology:Genotyping Market Forecast to Grow at 22.3% CAGR to 2020 2Genotyping Market Forecast to Grow at 22.3% CAGR to 2020 3Genotyping Market Forecast to Grow at 22.3% CAGR to 2020 4Genotyping Market Forecast to Grow at 22.3% CAGR to 2020 5North America Ophthalmology Cataract Surgery Devices Market by Sub-Market, by End-User - Analysis and Forecast to 2019 2North America Ophthalmology Cataract Surgery Devices Market by Sub-Market, by End-User - Analysis and Forecast to 2019 3Edwards Lifesciences Corporation Completes Acquisition Of CardiAQ 2
Enhances the eye color of light-eyed patients....
Expressions Accents contact lenses let you enhance your eyes natural color while enjoying incredible comfort and outstanding vision quality....
Modern, innovative and quick Intense Pulsed Light system. The Flash 1 is light and very compact, thus easily portable. Available in two different colors....
... Vasculight SR improves the appearance of photo-aged ... benign brown pigments, telangiectasias, and broken capillaries. ... pulsed light (IPLTM) treats pigmentary sun damage ... combined approach of IPL and the Nd:YAG ...
Medicine Products: