Navigation Links
Study reveals current multi-component vaccines may need reworking
Date:5/7/2009

s cause a T cell expansion after the complexes have arrived at the cell surface, as well as through DM editing inside the cell. A peptide's persistence at the cell surface also controls the ability of CD4 T cells to continue to expand. Importantly, this additional level of control over immunodominance by stability was only detected when many peptides were present, and were "competing" to see which would trigger a T cell response.

The team also found that low-stability peptide:class II complexes support the initial priming and expansion of CD4 T cells, but the expansion is "strikingly aborted" in the presence of competitive T cell responses to immunodominant peptides. Peptides that fall off of MHC class II molecules too quickly fail to sustain the expansion.

"What we saw is that if a dendritic cell offers weak or unstable peptides alone, T cell responses move forward," said Sant, the study's lead author. "But if we offered weak peptides in the presence of immunodominant ones, the weak peptides trigger an expansion at first, but then the response stalls. This competitive aspect is a new and has profound implications for vaccine design."

While still a theory, Sant speculates that losses in some T cell responses can be explained in part by trogocytosis, a process where T cells "steal" key pieces of the dendritic cell each time they dock onto it as a step in their decision to start expanding. Stolen pieces may include the peptide at hand, the MHC class II protein and so called co-stimulatory molecules. If there are many more of immunodominant peptide-MHC class II complexes initially displayed by the dendritic cell due to DM editing, and if cryptic peptides are falling off the MHC class II complex at a faster rate, and if T cells poach from the peptide-bearing dendritic cell with each pass, dominant peptides would continue activating T cells long after responses to cryptic peptides had petered out.

Without causing an actual infection
'/>"/>

Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3 4 5 6

Related medicine news :

1. UIC receives $1M HUD grant to study green healthy housing
2. PEAK Surgical Announces Positive Fascia Incision Healing Results From Preclinical Study of PEAK PlasmaBlade(TM) for Gynecologic Surgery
3. New study reveals the financial effects of stroke in China
4. Study Finds That Patients With Excessive Sweating Condition Are More Likely to Develop Skin Infections
5. Study in pregnant women suggests probiotics may help ward off obesity
6. No Safe Bets for Casino Workers: NIOSH Study Shows Casino Workers Face Toxic Conditions
7. SCAI Statement on A National Study of the Effect of Individual Proton Pump Inhibitors on Cardiovascular Outcomes in Patients Treated with Clopidogrel Following Coronary Stenting: The Clopidogrel Medco Outcomes Study
8. NIH multicenter AIDS cohort study commemorates 25 years of discovery
9. Pitt study on alcohol reveals drinkers not only zone out -- but also are unaware that they do
10. ABCs and No Skinned Knees: Study Reveals Various Barriers to Physical Activity in Child Care
11. Large Study of Lacrisert(R) Dry Eye Insert:
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... , , WEDNESDAY, May 22 (HealthDay News) -- People who ... to attempt suicide, whether or not they also suffer ... new study. "Clinicians who are seeing patients with ... increased risk of suicide," said study co-author Mark Ilgen, ... and Evaluation Center in Ann Arbor, Mich. "Although ...
(Date:5/22/2013)... York (PRWEB) May 22, 2013 ... of the DePuy Pinnacle Hip Replacement System continue to ... Federal Court, Bernstein Liebhard LLP reports. According to ... DePuy Orthopaedics to produce monitoring reports associated with a ... company’s medical device marketing practices. Plaintiffs maintained in ...
(Date:5/22/2013)... According to a May 14, 2013 US News and ... Cancer Surgery,” modern medical technology has given women with ... a whole new light. Since the new approach known as ... cancer and mastectomies with greater hope for a positive ... plastic surgery to oncology, women had little choice but to ...
(Date:5/22/2013)... Michigan study challenges previous research that suggests umpire ... study, a collaboration between researchers at U-M and ... into the controversial argument over whether MLB umpires ... of the same race. It found little statistical ... associate professor of sport management at the U-M ...
(Date:5/22/2013)... By Maureen Salamon HealthDay Reporter , , WEDNESDAY, ... each cause a great deal of suffering, but new ... linked to something else entirely -- a smaller brain. ... double the risk of depression, scientists wanted to determine ... The difference in size -- about 2 percent -- ...
Breaking Medicine News(10 mins):Health News:Migraine, Chronic Back Pain Tied to Higher Suicide Risk 2Health News:Migraine, Chronic Back Pain Tied to Higher Suicide Risk 3Health News:DePuy Pinnacle Lawsuit News: Bernstein Liebhard LLP Notes New Order in Federal Pinnacle Litigation Requiring Production of Monitoring Reports from Federal Investigation 2Health News:DePuy Pinnacle Lawsuit News: Bernstein Liebhard LLP Notes New Order in Federal Pinnacle Litigation Requiring Production of Monitoring Reports from Federal Investigation 3Health News:Breast Augmentation – New Option for Breast Cancer Surgeries 2Health News:U-M study challenges notion that umpires call more strikes for pitchers of same race 2Health News:Having Both Migraines, Depression May Mean Smaller Brain 2Health News:Having Both Migraines, Depression May Mean Smaller Brain 3
... -- A University of Michigan Health System laboratory study reveals ... could lead to a new treatment for those with sickle ... in this week,s early edition of the Proceedings of ... preventing the painful episodes and organ damage that are common ...
... Gordon HealthDay Reporter , TUESDAY, Nov. 1 (HealthDay ... their risk of developing cancer compared to the general population. ... cancer, according to new research. In any ... transplant is just 0.7 percent. And experts say the benefits ...
... Gardner HealthDay Reporter , TUESDAY, Nov. 1 ... disorder don,t appear to raise the risk of heart ... adults, new research shows. And if any ... Concerta does exist, the danger in absolute numbers would ...
... equation that is difficult to solve for most people, but ... transport can be an almost insurmountable task. A newly launched ... now enlisting the help of the senior citizens themselves to ... hoped that the results will lead to better urban planning. ...
... -- Women undergoing angioplasty, a procedure to unblock a clogged ... to new research. However, the study also shows ... an angioplasty than male patients. In conducting the study, ... Interventions , researchers analyzed information on almost 4,800 women and ...
... from Rhode Island Hospital examined how the perception of ... Through a web survey with embedded interventions, the researchers ... indicators of patient satisfaction, while staff reported changing or ... paper was published in the European Journal of ...
Cached Medicine News:Health News:Researchers reveal potential treatment for sickle cell disease 2Health News:Cancer Risk Doubles After Organ Transplant, Study Finds 2Health News:Cancer Risk Doubles After Organ Transplant, Study Finds 3Health News:Little Evidence of Heart Risks From ADHD Meds 2Health News:Little Evidence of Heart Risks From ADHD Meds 3Health News:Little Evidence of Heart Risks From ADHD Meds 4Health News:Senior citizens as co-researchers to improve urban planning 2Health News:Women No More Likely to Die After Angioplasty 2Health News:How staff perceptions of their roles impact patients experience in the emergency department 2Health News:How staff perceptions of their roles impact patients experience in the emergency department 3
(Date:5/22/2013)... SUNNYVALE, Calif. , May 22, 2013   ... today that its management is scheduled to present at ... New York on Thursday, June 6, 2013 ... live webcast of the presentation will be available online ... at  http://www.accuray.com/investors . The webcast replay of ...
(Date:5/22/2013)... Del. and MUNICH , May ... developer, manufacturer and marketer of transcatheter aortic valve implantation (TAVI) ... its first interim results of the J enaValve Eval ... I n Pa T ients with S E vere ... Paris . JUPITER is a post-market registry to ...
(Date:5/22/2013)... May 22, 2013  The Lupus Research Institute (LRI) ... advancing new treatments for lupus nephritis, a serious kidney ... patients. The conference launched a new international alliance of ... Trials Network (LNTN). More than 50 of ... came together to focus on two critical questions: 1) ...
Breaking Medicine Technology:First Results Of The JUPITER Registry On Long Term Performance And Safety Of The Transapical JenaValve TAVI System 2First Results Of The JUPITER Registry On Long Term Performance And Safety Of The Transapical JenaValve TAVI System 3First Results Of The JUPITER Registry On Long Term Performance And Safety Of The Transapical JenaValve TAVI System 4Lupus Research Institute Hosts First International Conference to Advance New Treatments for Lupus Nephritis 2
... The Bright Starlet is the world's smallest ... instrument with a choice of handwheel or lever ... is easy-to-clean and resist common decontaminating agents. An ... of the refrigeration system and to reduce frosting ...
... ASP300 smart tissue processor features superior user ... is a fully enclosed, stand-alone system for ... This new tissue processor combines proven technology ... screen and easy to use,yet powerful software. ...
... The Leica ASP200 is an advanced ... in standard and routine histopathology applications. Proven ... interface and smart operating software are the ... operations are simplified and the software includes ...
... microtome with automatic fine/trim- feed system, ... precision cross roller bearings. For sectioning ... in biological, botany, and materials science. ... 90 mm can be accommodated. Performance, ...
Medicine Products: