Navigation Links
Study reveals current multi-component vaccines may need reworking
Date:5/7/2009

ptides on the cell's surface for consideration by T cells gathered there. Activated T cells begin dividing, which greatly increase their number, until they become capable of the destroying the pathogen in question when exposed to high enough levels of the peptide representing it.

Andrea Sant, Ph.D., professor within the David H. Smith Center for Vaccine Biology and Immunology at the University of Rochester Medical Center, published a July 2005 article in the journal Immunity which revealed the quality that confers immunodominance on a peptide to be the strength and lifespan (kinetic stability) of its bond to the MHC class II protein. Kinetic stability determines whether, in the face of competing reactions, a peptide:MHC class II complex can accumulate at the surface of the dendritic cell, and then remain intact long enough to sustain T cell expansion. Dr. Sant's team found that immunodominant peptides held onto to MHC molecules ten to one hundred times longer than nondominant, or "cryptic," peptides because they fit together better. In the years since, Sant and colleagues have determined how the kinetic stability of the MHC:peptide bond has its effect.

In 2006, she published a study in the Journal of Experimental Medicine that found an enzyme called human leukocyte antigen-DM opens pockets on the MHC class II molecule for a given peptide to fit into it before the complex heads to the cell's surface to recruit T cells. Within dendritic cells (and related cell types that present peptides to immune cells), DM was found to favor peptides with highly stable MHC interactions, a process dubbed "DM editing." Sant's team found kinetically stable peptide-MHC complexes arrived at the cell surface as much as 100 times more often than cryptic peptides, and thought DM editing was solely responsible for determining immunodominance.

The current paper found, however, that the persistence of peptide-MHC Class II bonds also determines which peptide
'/>"/>

Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. UIC receives $1M HUD grant to study green healthy housing
2. PEAK Surgical Announces Positive Fascia Incision Healing Results From Preclinical Study of PEAK PlasmaBlade(TM) for Gynecologic Surgery
3. New study reveals the financial effects of stroke in China
4. Study Finds That Patients With Excessive Sweating Condition Are More Likely to Develop Skin Infections
5. Study in pregnant women suggests probiotics may help ward off obesity
6. No Safe Bets for Casino Workers: NIOSH Study Shows Casino Workers Face Toxic Conditions
7. SCAI Statement on A National Study of the Effect of Individual Proton Pump Inhibitors on Cardiovascular Outcomes in Patients Treated with Clopidogrel Following Coronary Stenting: The Clopidogrel Medco Outcomes Study
8. NIH multicenter AIDS cohort study commemorates 25 years of discovery
9. Pitt study on alcohol reveals drinkers not only zone out -- but also are unaware that they do
10. ABCs and No Skinned Knees: Study Reveals Various Barriers to Physical Activity in Child Care
11. Large Study of Lacrisert(R) Dry Eye Insert:
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/4/2015)... is no stranger to drug addiction. The bustling city has ... from the potential threat of Kratom. In a report by ... Kratom is a “drug of concern.” Although Kratom is legally ... Southeast Asia acts as a stimulant in low doses, yet ... similar to heroin withdrawal, and includes tremors, irritation, anxiety, and ...
(Date:3/4/2015)... SIGVARIS proved innovative when ... first compression therapy collection designed exclusively for men. ... USA is proud to announce the launch of three ... Constructed from a unique, extremely fine synthetic fiber, MIDTOWN ... socks and thigh-highs offer a tailored look that is ...
(Date:3/4/2015)... According to a new report published ... the U.S. suffer from gastroesophageal reflux disease (GERD), more ... to control acid production, but these can have side ... the problem and lead to other uncomfortable digestive conditions. ... the lower esophageal sphincter does not function properly. Anti-reflux ...
(Date:3/4/2015)... 04, 2015 In a small ceremony with ... on their new facility in New Port Richey on February ... new facility will allow the Florida drug detox facility ... drug abuse epidemic through treatment and education. “Due to our ... in the United States, we made the decision that expanding ...
(Date:3/4/2015)... 04, 2015 Jeannie Mai, TV personality, fashion ... graces the cover of the print publication. Mai embraces the ... organic when shopping for clothes and personal care products. In ... about her commitment to an organic diet. She mentions, “Having ... only in gymnastics, but also now as I’m a full ...
Breaking Medicine News(10 mins):Health News:Columbus, OH Combats the Sale of Kratom as a Drug, Harbor Village Detox Stresses Caution 2Health News:Building on the Success of MIDTOWN MICROFIBER, SIGVARIS Expands Popular Compression Collection with Longer Foot Length Offerings 2Health News:New and Proven Acid Reflux Treatments Offer Relief to Millions of Americans 2Health News:New and Proven Acid Reflux Treatments Offer Relief to Millions of Americans 3Health News:Novus Medical Detox Hosts Ribbon Cutting Ceremony at Pasco County Facility 2Health News:Novus Medical Detox Hosts Ribbon Cutting Ceremony at Pasco County Facility 3
... MINNEAPOLIS / ST. PAUL Minn. (October 28, 2010) ... Medical Center researchers have discovered a correlation between increased ... and the debilitating, involuntary flashbacks triggered by post traumatic ... PTSD through concrete evidence of neural activity, its impact ...
... HealthDay Reporter , THURSDAY, Oct. 28 (HealthDay ... green tea might help protect women from breast cancer, ... conclusion. "We found no overall association between green ... Japanese women who have habitually drunk green tea," said ...
... , WEDNESDAY, Oct. 27 (HealthDay News) -- Children ... increased risk for obesity in adulthood, a new study ... the symptoms of ADHD -- such as inattention, hyperactivity ... obese, according to researchers from Duke University Medical Center, ...
... , WEDNESDAY, Oct. 27 (HealthDay News) The ... are associated with heightened activity on the right side ... research that included 80 people with PTSD (many of ... and 284 people without the condition, researchers used a ...
... , BOSTON--A new oral drug caused dramatic shrinkage of a ... by an abnormally activated protein, physician-scientists from Dana-Farber Cancer Institute ... England Journal of Medicine . A second patient who ... mutant protein, called ALK (named for the first disease in ...
... A comprehensive review of national opinion polls, including newly released ... for a Democratic congressional candidate in 2010 and those who ... district hold starkly different views of what they want the ... between Democratic and Republican leaders in Congress on this issue. ...
Cached Medicine News:Health News:U of M researchers identify possible key to treating, understanding post-traumatic stress disorder 2Health News:Study Finds Green Tea Offers No Protection From Breast Cancer 2Health News:Children with ADHD Symptoms at Higher Risk of Obesity 2Health News:PTSD Linked to 'Hyperactivity' in Right Brain 2Health News:'Smart drug' targets new mutation, dramatically shrinks aggressive sarcoma and lung cancer 2Health News:'Smart drug' targets new mutation, dramatically shrinks aggressive sarcoma and lung cancer 3Health News:Prospective voters and the new health care law 2
(Date:3/4/2015)... --Aethlon Medical, Inc. (OTCQB:AEMD), the pioneer in developing targeted ... announced that James A. Joyce , Aethlon Medical ... the 27th Annual ROTH Conference on March 10, 2015 ... California . To learn more about the ROTH ... live webcast of the presentation will be available on ...
(Date:3/4/2015)... 2015  Students from Indiana University School of Medicine ... are discovered. Through a partnership with Lilly ... IU School of Medicine are learning about drug development ... different and important roles in bringing new and innovative ... educator, scientific investigator, and health system administrator, I recognize ...
(Date:3/4/2015)... LAKE CITY , March 4, 2015  ECR ... VAR ) is showcasing a full spectrum of ... improve image quality, reduce costs, and enable greater patient ... cone-beam CT imaging systems.  These solutions are on display ... in Vienna, Austria this week.   ...
Breaking Medicine Technology:Aethlon Medical to Present at the 27th Annual ROTH Conference 2Lilly and IU School of Medicine Partner on Rotation Program for Medical Students 2Lilly and IU School of Medicine Partner on Rotation Program for Medical Students 3Varian Medical Systems to Showcase New X-Ray Imaging Components at the European Congress of Radiology (ECR) Annual Meeting 2Varian Medical Systems to Showcase New X-Ray Imaging Components at the European Congress of Radiology (ECR) Annual Meeting 3
... American Medical Systems® (AMS) (NASDAQ: AMMD), a ... and female pelvic health, today announced it has received ... Welfare (MHLW) to market and distribute its GreenLight HPS® ... Hyperplasia (BPH), or enlarged prostate, in Japan. ...
... 2011 Misonix, Inc. (NASDAQ: MSON ), ... innovative, therapeutic, ultrasonic products worldwide for wound debridement, cosmetic ... applications, announced today that it will present at the ... 2011 at the Le Parker Meridien Hotel in New ...
Cached Medicine Technology:American Medical Systems' GreenLight HPS® Approved for Use in Japan 2Misonix to Present at the MDB Capital Bright Lights Conference on May 11, 2011 2
The new CR6-45NM non-mydriatic retinal camera is an ideal diagnostic tool for ophthalmologists, optometrists and other medical professionals, especially when it comes to detecting and monitoring diab...
FF 450plus IRu Fundus camera with Visupac / System 431. Digital results in all capture modes and unlimited Visupac software....
An ideal choice for film photography. The new TRC-50FXC provides 35mm color and Polaroid capability....
The most advanced retinal cameras for fluorescein, color and ICG angiography with full digital imaging capability....
Medicine Products: