Navigation Links
Study raises safety concerns about experimental cancer approach
Date:1/25/2011

A study by researchers at Washington University School of Medicine in St. Louis has raised safety concerns about an investigational approach to treating cancer.

The strategy takes aim at a key signaling pathway, called Notch, involved in forming new blood vessels that feed tumor growth. When researchers targeted the Notch1 signaling pathway in mice, the animals developed vascular tumors, primarily in the liver, which led to massive hemorrhages that caused their death.

Their findings are reported online Jan. 25 in the Journal of Clinical Investigation and will appear in the journal's February issue.

A number of anti-Notch therapies now are being evaluated in preclinical and early clinical trials for cancer. They target Notch1 as well as the three other signaling pathways in the Notch receptor family. The current research did not study any of these specific therapies in mice but instead focused on the potential side effects of chronically disrupting the Notch1 signal in individual cells.

"Our results suggest that anti-Notch1 strategies are bound to fail," says Raphael Kopan, PhD, professor of developmental biology and of medicine at the School of Medicine. "Without the Notch1 signal, cells in the vascular system grow uncontrollably and produce enlarged, weakened blood vessels. Eventually, the pressure within those vessels exceeds their capacity to hold blood, and they rupture, causing a dramatic loss of blood pressure, heart attack and death."

Notch plays a crucial role in determining a cell's fate and is active throughout a person's life. In recent years, the pathway has emerged as a target to block the formation of blood vessels called angiogenesis in solid tumors.

Kopan says he is not advising that anti-Notch clinical trials already under way be halted. These early trials generally involve short-term use of the drugs and are designed to assess safety. However, he says patients who take anti-Not
'/>"/>

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. New study finds reminders for immunizations challenging for pediatric practices
2. Elderly With Dementia, Delirium Confused by ER Visits: Study
3. Rise in Some Head and Neck Cancers Tied to Oral Sex: Study
4. Workers most invested in their jobs have highest stress levels, CAMH study shows
5. Stress of War Spurs Changes in Brain Activity, Study Finds
6. Study examines earlier use of heart pumps in growing group of heart failure patients
7. Study Finds Round Numbers Are Strong Motivators
8. Apology May Leave You Feeling Unsatisfied, Study Finds
9. Study Suggests How Music Fools the Ear
10. Case Western Reserve receives $7.8M to study manic symptoms in children
11. Childhood Last Name Predicts Whether You Buy Early, Late: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study raises safety concerns about experimental cancer approach
(Date:5/3/2015)... 03, 2015 HealthPostures, a pioneering ... announces its appearance at the , May 5 - ... HealthPostures will exhibit at the conference include its bestselling ... stand solutions is the 6100 TaskMate Executive. Features of ... an adjustable keyboard tray, extended platform work surface and ...
(Date:5/2/2015)... 2015 Vancouver fencing company, QS Fencing, has ... advice to prospective clients related to their questions on railings ... railings around their decks and patios. While that seems like ... up once the person rolls up their sleeve to start ... railing in finding a gate that matches it. , Instead ...
(Date:5/2/2015)... May 02, 2015 It’s a pattern ... natural disaster strikes anywhere on this planet, cyber scammers ... sympathy and compassion for their own personal gain. ... Emergency Readiness Team) issued an alert titled “Nepal ... email scams citing the earthquake in Nepal. The scam ...
(Date:5/2/2015)... East Liverpool, Ohio (PRWEB) May 02, 2015 ... of East Liverpool City Hospital (ELCH) gathered to celebrate ... direction of River Valley Health Partners (RVHP), had zero ... and zero urinary catheter associated infections. ELCH was also ... , The management team at ELCH credited the ...
(Date:5/2/2015)... OR (PRWEB) May 02, 2015 ZoomCare, ... it has submitted plans to offer its new healthcare ... Exchange. The ZOOM+ Personal Health Insurance System is the ... up to enhance human performance. ZOOM+ Personal Health Insurance ... healthcare delivery system that are subject to review and ...
Breaking Medicine News(10 mins):Health News:HealthPostures to Appear at the Minnesota Safety and Health Conference 2Health News:HealthPostures to Appear at the Minnesota Safety and Health Conference 3Health News:Professional Staff at QS Fencing Company Now Provides Advice on Railings and Gates 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 4Health News:East Liverpool City Hospital Celebrates Patient Care Improvements 2Health News:ZoomCare Applies to be on Oregon Exchange 2
... to be presented today at the Society for Maternal-Fetal Medicine,s ... researchers will present findings that show that many women are ... their routine third trimester screening and a rapid test performed ... a leading cause of neonatal infection. GBS is a bacterium ...
... and older, includes nearly 3.8 million divorced men and ... end-of-life issues can be particularly difficult for singles without ... University of Missouri provides insight into the experiences of ... assistance with daily tasks and management of health needs. ...
... -- More than one-quarter of women with apparent early-stage ... check for cancer spread, which nearly doubles these patients, ... at the University of California Davis Cancer Center and ... registry data of 721 presumed early-stage ovarian cancer patients ...
... HealthDay Reporter , THURSDAY, Feb. 10 (HealthDay News) -- In ... researchers found that taking folate during pregnancy didn,t appear ... data do not support a protective effect of folate on ... have an adverse effect on pregnancy either," said study author ...
... Bayston in the School of Clinical Sciences, PhD student and ... professional training fellowship of almost 160,000 from Arthritis Research UK ... with broken bones. Pins used to mend broken ... cent of patients being treated in this way develop infections, ...
... than two thousand physicians, some of the top ... medicine, especially high risk pregnancies, gathered today for ... four days of intensive research presentations. Presentations ... (SMFM) annual meeting, The Pregnancy Meeting , represent ...
Cached Medicine News:Health News:Third trimester group B streptococcus test doesn't accurately predict presence during labor 2Health News:Study examines phenomenon of women caring for ex-husbands 2Health News:Folate May Not Protect Against Premature Birth 2Health News:Folate May Not Protect Against Premature Birth 3Health News:Anti-bacterial collar to help mend broken bones 2Health News:SMFM highlights significance of spina bifida research findings 2
(Date:5/1/2015)... Calif. , May 1, 2015  Legendary actor ... Inc. in a new PBAFacts campaign designed to educate ... to learn more about Pseudobulbar Affect (PBA) and to ... idea that an actor has the ability to cry ... the lack of control experienced by people living with ...
(Date:5/1/2015)... PORTLAND, Ore. , May 1, 2015 ... medical risk assessment company that develops, manufactures and markets ... evaluating chronic diseases, today reported financial results for the ... "In the first quarter of 2015, Semler reported continued ... sequential quarter over quarter revenue growth of 14%," said ...
(Date:5/1/2015)... -- Cambrex Corporation (NYSE: CBM ) reports results for ... Highlights , Sales increased 18% compared to the ... impact, driven by Innovator products and Controlled Substances. , ... first quarter of 2014. , GAAP Diluted EPS from ... last year and Adjusted Diluted EPS was $0.29 compared to ...
Breaking Medicine Technology:Danny Glover Joins PBA Facts Campaign, to Educate and Build Awareness of Pseudobulbar Affect (PBA), a Little Known but Widespread Neurologic Condition 2Danny Glover Joins PBA Facts Campaign, to Educate and Build Awareness of Pseudobulbar Affect (PBA), a Little Known but Widespread Neurologic Condition 3Semler Reports First Quarter 2015 Financial Results 2Semler Reports First Quarter 2015 Financial Results 3Semler Reports First Quarter 2015 Financial Results 4Semler Reports First Quarter 2015 Financial Results 5Cambrex Reports First Quarter 2015 Financial Results 2Cambrex Reports First Quarter 2015 Financial Results 3Cambrex Reports First Quarter 2015 Financial Results 4Cambrex Reports First Quarter 2015 Financial Results 5Cambrex Reports First Quarter 2015 Financial Results 6Cambrex Reports First Quarter 2015 Financial Results 7Cambrex Reports First Quarter 2015 Financial Results 8Cambrex Reports First Quarter 2015 Financial Results 9Cambrex Reports First Quarter 2015 Financial Results 10Cambrex Reports First Quarter 2015 Financial Results 11
Desmarres Retractor Size 4...
Desmarrres Lid Retractor, round serrated handle, polished finish, overall length 130 mm....
Size 4 - 2.25 mm...
Highly versatile, efficient, compact and accurate digital readout display....
Medicine Products: