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Study puts brakes on extending indications for cardiac resynchronization therapy
Date:11/6/2007

ivers electrical impulses to each ventricle simultaneously, which stimulates synchronous contraction. This synchronous contraction improves the heart's pumping efficiency, which improves patients' symptoms.

Current guidelines support the use of CRT in patients with moderate to severe heart failure, an ejection fraction less than or equal to 35 percent, and a prolonged QRS duration, greater than 120 milliseconds, what physicians refer to as a "wide QRS."

The RethinQ investigators followed 172 patients with advanced heart failure, mechanical dyssynchrony (when the heart's main pumping chambers, the ventricles, do not contract together efficiently) and a QRS duration of less than 130 milliseconds, for six months. Eighty-five patients were randomly selected to receive treatment with CRT. The other 87 were followed as controls.

The sub-group of patients with the longest QRS duration, between 120 and 130 milliseconds, did show improvement from CRT, as measured by peak oxygen uptake during exercise testing. This sub-group already is indicated for CRT, said Beshai, and this finding "supports previous research on this patient sub-group." Patients with a QRS duration of less than 120 milliseconds, however, did not show improvement.

"While there may be a group of patients with a narrow QRS who can benefit from CRT therapy, the measures of dyssynchrony used in the RethinQ study did not identify them," Beshai said. "These new data are helpful for all heart failure physicians as we continue to determine the best criteria for assessing who will most benefit from CRT therapy."


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Contact: John Easton
John.Easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
Source:Eurekalert

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