Navigation Links
Study provides hope that some transplant patients could live free of anti-rejection drugs
Date:8/20/2007

STANFORD, Calif. - People with organ transplants, resigned to a lifetime of anti-rejection drugs, may now have reason to hope for a respite, say researchers at Lucile Packard Children's Hospital and the Stanford University School of Medicine. Using a simple blood sample, the scientists have identified for the first time a pattern of gene expression shared by a small group of patients who beat the odds and remained healthy for years without medication.

The findings suggest that transplant recipients who share the same pattern of genes but are still on conventional medication may be able to reduce or eliminate their lifelong dependence on immunosuppressive drugs. The study may also help physicians determine how best to induce acceptance, or tolerance, of donor organs in all transplant patients, regardless of their gene expression profiles.

"We're very excited by the findings," said Minnie Sarwal, MD, PhD, a pediatric nephrologist at Packard Children's. "Most transplant patients who stop taking their medications will reject their organ. But now we have the chance of telling someone committed to a lifetime of drugs that it may be possible to minimize their exposure to the drugs."

Although the anti-rejection medications, known as immunosuppressants, tamp down the immune system enough to permit lifesaving organ transplants, their benefits come at a price. They also quash the body's natural response to dangerous invaders, such as bacteria and viruses, and to rogue cancer cells. Transplant physicians prescribing immunosuppressants to their patients walk a fine line between avoiding organ rejection and increasing the risk of infection and cancer.

Sarwal, associate professor of pediatrics at the medical school, is the senior author of the research, which will be published Aug. 20 in the advance online edition of the Proceedings of the National Academy of Sciences. She collaborated with physicians at Stanford and Packard Children's, as
'/>"/>

Contact: Krista Conger
kristac@stanford.edu
650-725-5371
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Gene study links endometriosis, infertility
2. Study reveals how stress can make you sick
3. Study points out that HIV vaccine may not be accepted easily
4. A new study surpasses Gene Therapy Hurdle
5. Tomato Sauce reduces Cancer Risk- Study
6. A question on study of Adult Stem Cell
7. Study on obesity and heart failure
8. National Lung Study in the process
9. Marijuana gateway theory strengthened by study of twins
10. Old theory of adaptation confirmed by new study
11. Study casts doubt on keyboard ills
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... San Diego, CA (PRWEB) March 27, 2015 ... will launch its Protect Our Children (POC) NOW! vitamin ... at the Medical University of South Carolina (MUSC), and ... POC will be available at no cost to a ... less gestation who live within these two service areas. ...
(Date:3/27/2015)... CT (PRWEB) March 27, 2015 Trail mix ... after a workout, on weekend hikes and during the game! ... benefits. Aurora Natural is proud to introduce a new line ... taste buds. Deliciously rich and flavorful selections packed with nutritious, ... seeds, dried fruit and grains that add protein and fiber ...
(Date:3/27/2015)... 2015 Since September 2014, the country singer ... tour after having been in retirement for a period of ... performer to return to touring, and concert events have been ... will likely sell out for the two shows recently scheduled ... to view the inventory of discounted Garth Brooks tickets for ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 April 2015 is ... – the Sesquicentennial. To honor America’s bloodiest war and the ... Adams Trust presents A Tribute to the Civil War and ... Friday, April 17, 2015, at the Jane Pickens Theater in ... Civil War-Lincoln scholar, will serve as the master of ceremonies. ...
(Date:3/27/2015)... March 27, 2015 In light of ... number 1:15-cv-10429, U.S. District Court, District of Massachusetts; and ... Eastern District of Pennsylvania), the San Diego personal injury ... A.P.C. are announcing that they are available to investigate ... women who were prescribed Zofran while pregnant and who ...
Breaking Medicine News(10 mins):Health News:GrassrootsHealth Moves Vitamin D into Practice with Pregnant Women 2Health News:GrassrootsHealth Moves Vitamin D into Practice with Pregnant Women 3Health News:GrassrootsHealth Moves Vitamin D into Practice with Pregnant Women 4Health News:Aurora Product, Inc. Introduces New Line of Specialty Trail Mixes 2Health News:Garth Brooks Tickets for Omaha: BuyCheapTicketsToEvents.com Draws Customers by Discounting Prices on 2015 Tickets for Garth Brooks’ Tour Stops at CenturyLink Center 2Health News:Relive the Civil War, the Presidency and Shocking Assassination of Abraham Lincoln through Lincoln’s Own Words and the Music of a 46-Piece Orchestra 2Health News:Relive the Civil War, the Presidency and Shocking Assassination of Abraham Lincoln through Lincoln’s Own Words and the Music of a 46-Piece Orchestra 3Health News:Relive the Civil War, the Presidency and Shocking Assassination of Abraham Lincoln through Lincoln’s Own Words and the Music of a 46-Piece Orchestra 4Health News:The Law Office of Melinda J. Helbock, A.P.C. Announces That It Is Now Accepting Case Reviews for Potential Zofran Birth Defect Lawsuits 2
... Estimates of Diagnosed Diabetes Now Available for all U.S. ... nearly,24 million people in the United States, an increase ... to new 2007 prevalence data estimates,released today by the ... nearly 8 percent of the U.S. population has diabetes., ...
... - Stimulant medications such as Ritalin have been prescribed ... and their popularity as "cognition enhancers" has recently surged ... starting to catch up is knowledge of what these ... publishing online this week in Biological Psychiatry , ...
... CHEVY CHASE, Md., June 24 "Heart disease,the main ... the most preventable,illnesses and is largely treatable through diet, ... disease,said today., Nearly 700,000 men and women die ... "Although diagnosis of heart disease can be elusive and ...
... OAKLAND, Calif., June 24 Kaiser Foundation Health ... the,appointment of Paul B. Records as senior vice ... Records has been leading the,national human resources function ... overseeing the company,s relations with its 30 unions, ...
... Americans are experiencing,rising prices on many essentials, including ... one of the fastest-growing medical,expenses. From 1990 to ... to $200.7 billion, according to a recent report ... Giant is introducing a new way for families, ...
... announced today Reproductive Health Matters , May 2008 ... Promoting Sexual and Reproductive rights". Under conditions of global ... growing numbers of refugees and internally displaced persons (IDPs) ... right to have rights,. By the end of ...
Cached Medicine News:Health News:Number of People With Diabetes Increases to 24 Million 2Health News:Number of People With Diabetes Increases to 24 Million 3Health News:Study uncovers how Ritalin works in brain to boost cognition, focus attention 2Health News:Study uncovers how Ritalin works in brain to boost cognition, focus attention 3Health News:Concerns About Heart Disease Voiced 2Health News:Paul B. Records Named Senior Vice President, Chief Human Resources Officer, for Kaiser Permanente 2Health News:New Giant Pharmacy Program Offers Relief for Your Family and Your Wallet 2Health News:May 2008 issue on conflict and crisis settings: Promoting sexual and reproductive rights 2
(Date:3/26/2015)... , 26. März 2015  Die ... wird vom 1. April 2015 an Zulassungsanträge für ... abgebenden Apotheken annehmen. Seit dem Start des ... Verband über 275 .pharmacy-Domainnamen zugelassen, die für ... Zeiten beantragt wurden. Die NABP startete .pharmacy ...
(Date:3/26/2015)... profiled MJ Freeway , a business software company for ... Did It," which features companies with unique paths to success. ... illustrates how two tech entrepreneurs from Telluride, Colorado ... industry. Writer ... Jessica Billingsley used their experience in the technology ...
(Date:3/26/2015)... a loved relative suffering from cancer - and you ... too expensive. The Austrian Centre of Industrial Biotechnology (acib) ... costs of highly valued drugs significantly. ... pathogens or cancer cells. Therapeutic antibodies are used as ... diseases such as multiple sclerosis. According to "bccresearch.com" the ...
Breaking Medicine Technology:Alle abgebenden Apotheken berechtigt, um ab dem 1. April 2015 .Pharmacy-Domainnamen zu beantragen 2MJ Freeway, Industry-Leading Software Solution for Cannabis Businesses, Featured in CNBC Special "How I Did It" 2World's First Method for Continuous Purification of Valuable Antibodies 2
... is a minimally invasive, tension-free technique that ... cm incision and requires minimal suturing. It ... open, anterior approach that can be completed ... patch is a self-expanding polypropylene patch that ...
... Bard Kugel hernia patch in constructed of ... construction creates a positioning pocket, which is ... placement. The patch also contains a patent ... the patch to spring open and maintain ...
... Hernia System is a sterile, pre-shaped, three-dimensional ... by a mesh cylinder to a circular ... 1 unique and innovative design combines the ... today in the repair of inguinal hernias. ...
Surgisis Inguinal Hernia Matrix is implanted to reinforce soft tissues in the inguinal floor to repair inguinal hernias. Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: