Navigation Links
Study provides clues to preventing and treating cancer spread
Date:7/28/2008

CHAPEL HILL Isn't it odd that cancer cells from one organ, such as the skin, can travel and take root in a totally different organ, like the lung?

What's more, why is it that certain cancers prefer to spread, or metastasize, to certain places? Prostate cancer usually moves to bone; colon cancer, to the liver.

To answer these questions, Dr. Hendrik van Deventer, assistant professor of medicine at the University of North Carolina at Chapel Hill and a member of the UNC Lineberger Comprehensive Cancer Center, turned to a century-old idea of cancer spread: English surgeon Stephen Paget's "seed and soil."

The idea is that the spread of cancer isn't just about the tumor itself (the seed), but also the environment where it grows (the soil). Other scientists have shown that cells from bone marrow can migrate and change the environment so that it is receptive to incoming cancer cells. These cells do so by forming small neighborhoods or niches within distant organs. Thus, biologists refer to these areas as "premetastic niches."

Van Deventer and his colleagues wanted to know what mysterious non-tumor cell could change a normal organ so cancer cells would invade. If scientists could discover the identity of that normal cell, maybe they could devise treatments to stop metastases.

In a study published in the July issue of The American Journal of Pathology, van Deventer showed for the first time that that cell could be a fibrocyte cells that travel around the body, rushing to the site of an injury to aid in healing when needed. The study also suggests ways to develop treatments to prevent metastases using already available medications.

"This study shows it's possible for fibrocytes to form the premetastatic niche. But it stops short of proving they positively are the cells," van Deventer said.

The UNC researcher's work with fibrocytes began when he wanted to figure out why "knockout mice" that are missing th
'/>"/>

Contact: Leslie Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. New AHRQ Study Finds Surgical Errors Cost Nearly $1.5 Billion Annually
2. Erectile dysfunction drugs allowed more chemotherapy to reach brain tumors in laboratory study
3. Study Disproves Belief That Hepatitis C Blunts HIV Drugs
4. Study shows emergency physicians have good first instincts in diagnosing heart attacks
5. Study suggests human visual system could make powerful computer
6. Australian Study Seeks Genetic Roots of Cerebral Palsy
7. Cranberry juice creates energy barrier that keeps bacteria away from cells, study shows
8. Milestone for cannabinoid MS study
9. Broad Institute earns grant to support pathbreaking diabetes study
10. New Study Shows Facial Plastic Surgery Helps African American's Perserve Ethnicity
11. Raw deal for foreign brides in Taiwan: study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... In “Cooking with Spirits for the Spirit: A ... Hall Svisdahl’s new cookbook, readers are transported into the world ... the pickiest eater drool. “I dedicate this book to the ... , Found within the 364 pages of “Cooking with Spirits ... from fast and simple to gourmet. Each recipe greets the ...
(Date:5/18/2013)... MAY 19, 2013 The American Society for Gastrointestinal ... of endoscopy during the ninth annual ASGE Crystal Awards ... the ASGE Foundation, this year,s event will begin at ... Orlando, Fla. , Held in conjunction with Digestive ... finest in leadership, research and scientific pursuit. The event ...
(Date:5/18/2013)... MD (May 19, 2013) The American Gastroenterological ... its 2013 research scholars. This year,s honorees are ... gastroenterology, hepatology or related areas, and with this ... , "These young researchers are the future of ... scholars who are paving the way for promising ...
(Date:5/18/2013)... (PRWEB) May 18, 2013 Online watch retailer ... Rolex watch owners at a fraction of its ... luxury timepieces in the world, buyers are urged to take ... to buying a Rolex watch from a brick-and-mortar store, buyers ... Rolex watches priced at unbelievable rates. Although some buyers ...
(Date:5/18/2013)... Reporter , , FRIDAY, May 17 (HealthDay News) -- As ... what is considered the "bible" of modern psychiatry this ... "This is unprecedented, the amount of commentary and debate ... American Psychiatric Association (APA). "It,s been an interesting phenomenon, ... to evaluate it and then make your own determination ...
Breaking Medicine News(10 mins):Health News:Janet Hall Svisdahl Announces Release of ‘Cooking with Spirits for the Spirit’ 2Health News:ASGE and ASGE foundation hold Crystal Awards dinner as part of Digestive Disease Week®, May 19, in Orlando 2Health News:ASGE and ASGE foundation hold Crystal Awards dinner as part of Digestive Disease Week®, May 19, in Orlando 3Health News:ASGE and ASGE foundation hold Crystal Awards dinner as part of Digestive Disease Week®, May 19, in Orlando 4Health News:ASGE and ASGE foundation hold Crystal Awards dinner as part of Digestive Disease Week®, May 19, in Orlando 5Health News:ASGE and ASGE foundation hold Crystal Awards dinner as part of Digestive Disease Week®, May 19, in Orlando 6Health News:ASGE and ASGE foundation hold Crystal Awards dinner as part of Digestive Disease Week®, May 19, in Orlando 7Health News:AGA Research Foundation Research Scholar Awards advance the work of promising gastroenterologists 2Health News:Time and Gems Offers Buyers the Largest Collection of Rolex Watches Yet 2Health News:Time and Gems Offers Buyers the Largest Collection of Rolex Watches Yet 3Health News:Latest Edition of Psychiatry's 'Bible' Launched Amid Controversy 2Health News:Latest Edition of Psychiatry's 'Bible' Launched Amid Controversy 3Health News:Latest Edition of Psychiatry's 'Bible' Launched Amid Controversy 4
... today announced that it has completed its first ... results from patient diaries indicating that Cuprindo™ is ... healthy volunteers, reported 100% compliance with the dosing ... daily over a seven day period. In addition, ...
... wide-ranging influence on so many areas of life that ... neurosocieties. To bring this community together, the European ... Science Foundation (ESF), has initiated a series of activities ... and ethical implications of new developments in the neurosciences. ...
... The law firm of Lieff,Cabraser Heimann & Bernstein, ... behalf of purchasers of the securities of American Dental,Partners, ... 10, 2005,and December 13, 2007, inclusive (the "Class Period")., ... Class Period,you may move the Court for appointment as ...
... keep Hillenbrand name as part of new parent company for ... Batesville Casket Company, ... doing business ... (NYSE: HB ) announced today that it has begun mailing a,notice ...
... 15 drugstore.com, inc.,(Nasdaq: DSCM ), a ... products, today announced that Dawn Lepore, chief executive,officer ... Pont, chief financial,officer, will be presenting at the ... 2008 and the Morgan Stanley Technology,Conference on March ...
... MLSS), the recognized leader in,advanced injection technologies, today announced that it will ... WHEN: Friday, February 22, 2008 - Sunday, February 24, 2008, ... McCormick Place Lakeside Center ... Chicago, Illinois, WHO: ...
Cached Medicine News:Health News:European Neuroscience and Society Network tackles neurosocieties head-on 2Health News:Lieff Cabraser Heimann & Bernstein, LLP Announces Class Action Lawsuits Have Been Filed Against American Dental Partners, Inc. 2Health News:Lieff Cabraser Heimann & Bernstein, LLP Announces Class Action Lawsuits Have Been Filed Against American Dental Partners, Inc. 3Health News:Hillenbrand Announces Mailing of Proxy Regarding Changing of Company Name in Conjunction with Planned Separation 2Health News:Hillenbrand Announces Mailing of Proxy Regarding Changing of Company Name in Conjunction with Planned Separation 3Health News:Hillenbrand Announces Mailing of Proxy Regarding Changing of Company Name in Conjunction with Planned Separation 4Health News:Hillenbrand Announces Mailing of Proxy Regarding Changing of Company Name in Conjunction with Planned Separation 5Health News:drugstore.com, inc. to Present at the Upcoming Jefferies 4th Annual Internet Conference and the Morgan Stanley Technology Conference 2Health News:Milestone Scientific to Exhibit at the Chicago Dental Society's 143rd Midwinter Meeting 2Health News:Milestone Scientific to Exhibit at the Chicago Dental Society's 143rd Midwinter Meeting 3
(Date:5/17/2013)... May 17, 2013  ConvaTec today announced that it will report its ... Berger , CEO, and Ed Borkowski , CFO, ... via telephone. To participate in the conference call within ... To participate in the conference call outside the U.S. and ... ID is 72195398. Participants should dial in 10 minutes prior ...
(Date:5/17/2013)... Rico , May 17, 2013  Serving a region ... Puerto Rico , Caribbean Imaging and Radiation Therapy (CIRT, ... radiation therapy capabilities with the acquisition of an Elekta Versa ... . Versa HD offers clinicians the versatility to deliver conventional ... body, while also enabling treatment of highly complex cancers that ...
(Date:5/17/2013)... Conn. , May 17, 2013  Boehringer ... in respiratory disease at the American Thoracic Society ... PA , May 17 – 22. ... product approved for the treatment of chronic obstructive ... powder)], as well as investigational compounds for asthma, ...
Breaking Medicine Technology:Puerto Rico's Caribbean Imaging and Radiation Therapy Center Orders Elekta's New Versa HD System for Treatment of Cancer Patients 2Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 2Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 3Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 4Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 5Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 6Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 7Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 8
... NEW YORK, Dec. 5, 2010 Pfizer Inc. (NYSE: ... of Directors has elected Ian C. Read, 57, currently ... Chief Executive Officer and Director. Mr. Read succeeds Jeffrey ... (Logo: http://photos.prnewswire.com/prnh/20100416/PFIZERLOGO) The Board,s Lead ...
... EAST HANOVER, N.J., Dec. 3, 2010 A newly ... a first-line treatment regimen including Zometa® (zoledronic acid) significantly ... newly diagnosed multiple myeloma patients compared with a regimen ... independent of the effect of Zometa on bone complications ...
Cached Medicine Technology:Pfizer Board of Directors Names Ian C. Read President and Chief Executive Officer 2Pfizer Board of Directors Names Ian C. Read President and Chief Executive Officer 3Pfizer Board of Directors Names Ian C. Read President and Chief Executive Officer 4Phase III Data Published in Lancet Show Novartis Drug Zometa® Improves Overall Survival in Newly Diagnosed Multiple Myeloma Patients 2Phase III Data Published in Lancet Show Novartis Drug Zometa® Improves Overall Survival in Newly Diagnosed Multiple Myeloma Patients 3Phase III Data Published in Lancet Show Novartis Drug Zometa® Improves Overall Survival in Newly Diagnosed Multiple Myeloma Patients 4Phase III Data Published in Lancet Show Novartis Drug Zometa® Improves Overall Survival in Newly Diagnosed Multiple Myeloma Patients 5Phase III Data Published in Lancet Show Novartis Drug Zometa® Improves Overall Survival in Newly Diagnosed Multiple Myeloma Patients 6Phase III Data Published in Lancet Show Novartis Drug Zometa® Improves Overall Survival in Newly Diagnosed Multiple Myeloma Patients 7Phase III Data Published in Lancet Show Novartis Drug Zometa® Improves Overall Survival in Newly Diagnosed Multiple Myeloma Patients 8
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: