Navigation Links
Study proposes new ovarian cancer targets
Date:3/13/2014

ast year in Biology of Reproduction that estrogen upregulates the protein in mouse ovaries and in estrogen-supplemented mouse ovarian tumors. In humans, long-term estrogen hormone replacement therapy has been associated with a greater risk of ovarian cancer.

Cell growth and death

Meanwhile, TAF2 may have its own cancer-related modus operandi. Work by other researchers has shown that TAF2 boosts the expression of a protein called C-SRC, that promotes cell growth and proliferation. Perhaps not surprisingly, other studies have found that C-SRC is overexpressed in ovarian tumors.

"Given these results, it is possible that TAF2 overexpression could increase transcription of C-SRC in some ovarian tumors," the researchers wrote.

But what of TAF9, which unlike its brethren seems to become notably less expressed in ovarian cancers? There, too, there is a suspicious mechanistic connection to ovarian cancer. TAF9 is a co-activator of the protein p53, which promotes cell death, a handy thing to promote in tumors. But p53 activity is also suppressed in ovarian cancer. Together, these changes may help ensure the survival of ovarian cancer cells.

Ribeiro and Freiman readily acknowledge that the case they build is circumstantial, but they argue it is more than enough for cancer researchers to look at TAFs as potential targets in their search for new treatments.

"We've compiled this hypothesis and provided the data that we think is relevant, but there still is much that is not known about it," Ribeiro said.

In the lab now, Ribeiro and Freiman are testing the effects in human ovarian cancer cells of manipulating TAF expression and function.


'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study proposes new ovarian cancer targets
(Date:9/16/2014)... Francisco, September 15, 2014Prostate cancer patients who received ... quality of life, as well as bladder and ... after RT, according to research presented today at ... Annual Meeting. Additionally, results indicate that parallel quality ... who receive different regimens of HPFX RT. , ...
(Date:9/16/2014)... who have had children (parous women) appear to ... breast cancer, the subtype that carries a higher ... of African ancestry. A similar relationship was ... between childbearing and increased risk of estrogen receptor-negative ... the women who had never breastfed. These findings, ...
(Date:9/16/2014)... better predict a man,s risk of getting prostate cancer ... largest-ever analysis of the cancer,s genetic biomarkers, reported in ... Health and Biomedical Innovation,s Dr Jyotsna Batra and Distinguished ... the large consortia of research hubs around the world, ... markers in 80,000 men. , "It,s the largest analysis ...
(Date:9/16/2014)... Definitive Healthcare , the ... providers, is pleased to announce the release of ... now available for subscription, features detailed hospital profiles ... affiliations. , The Canadian database spans Canada’s ten ... over 750 hospitals. Each hospital profile provides ...
(Date:9/16/2014)... 16, 2014 Gary F. Locke, the ... has selected Worldwide Speakers Group for exclusive representation of ... of Commerce and Governor of Washington, Locke is widely ... U.S.-China relations, global expansion, and business growth. , “Gary ... and how to grow an organization’s global presence in ...
Breaking Medicine News(10 mins):Health News:Prostate cancer patients who receive hypofractionated RT report consistent QoL 2Health News:Prostate cancer patients who receive hypofractionated RT report consistent QoL 3Health News:Lactation linked to reduced estrogen receptor-negative, triple-negative breast cancer risk 2Health News:New gene research helps pinpoint prostate cancer risk 2Health News:Canadian Hospital Database Now Offered by Definitive Healthcare 2Health News:Gary Locke, Former Ambassador to China, Selects Worldwide Speakers Group for Exclusive Lecture Representation 2
... of Canadian surgeons got a shock when the patient they ... ,Describing the case in the Lancet, lead doctor Dr. Alana ... team was startled to discover green blood flowing in the ... 42-year-old man was being operated upon to prevent his condition-compartment ...
... able to uncover the fate of the lost colony with ... than 100 people settled on the Roanoke Island in ... and historical narratives have gathered around 168 surnames that could ... the English trying to colonize the new world. ...
... of Buffalo, for the first time in its 23 years of ... . The festival attracts tens of thousand of people from all ... vendor's menu must meet standards on fat, salt and cholesterol. ... have mango sorbet and smoked chicken sandwiches along with the hot ...
... appear healthy, making it difficult to detect outbreaks of the ... Monday. ,Indonesia, the country worst hit by ... H5N1 outbreaks across its vast archipelago. ,"From our ... bird flu have not been showing the usual symptoms," Memed ...
... Hong Kong on Monday warned the public to stop ... industrial chemical. The customs department said samples contained ... was discovered in exports of Chinese toothpaste to Panama. ... toothpaste imports and Singapore has banned three Chinese brands. ...
... body representing the vast majority of Britain's casinos ... government plans to shake-up the country's gambling ... persuade the London-based court that Labour's policy to ... Vegas-style "super-casino," was treating existing gaming establishments with ...
Cached Medicine News:Health News:DNA Link to a Lost Colony 2Health News:Healthier Options at the Buffalo Food Fest 2
(Date:9/15/2014)... Health Minister Rona Ambrose today announced that ... $2.5 million in personal protective equipment (PPE) to the World ... the Ebola outbreak in West Africa . ... in the affected countries and has appealed to member states ... countries. Personal protective equipment such as respirator ...
(Date:9/15/2014)... Sept. 15, 2014  Alere Inc. (NYSE: ALR ... infectious disease, toxicology, cardiology and diabetes products and services, ... by former CEO Ron Zwanziger , filed a ... subsequently sent a letter to Gregg J. Powers ... due diligence in an effort to secure financing to ...
(Date:9/15/2014)... , Sept. 15, 2014  Patients in today,s changing ... more frequently in an outpatient setting versus a hospital. ... and to ensure that patients continue to receive high ... launch of its new internal medicine residency program. The ... often in office, clinic and even virtual settings. ...
Breaking Medicine Technology:Canada offers essential protective equipment to help stop the spread of Ebola in West Africa 2Canada offers essential protective equipment to help stop the spread of Ebola in West Africa 3Alere Responds To Letter From Former Executives 2Kaiser Permanente Hawaii Launches New Internal Medicine Residency Program 2Kaiser Permanente Hawaii Launches New Internal Medicine Residency Program 3
... 2011 Hospira, Inc. (NYSE: HSP ... technologies, today reported results for the third quarter ended Sept. ... and adjusted* diluted earnings per share were $0.66. (Adjusted* measures ... release and the attached schedules.) "As we indicated ...
... NEW YORK, Oct. 26, 2011 Reportlinker.com ... is available in its catalogue: ... Worldwide, 2009 to 2015 ... study has 484 pages, 235 tables and ...
Cached Medicine Technology:Hospira Reports Third-Quarter 2011 Results 2Hospira Reports Third-Quarter 2011 Results 3Hospira Reports Third-Quarter 2011 Results 4Hospira Reports Third-Quarter 2011 Results 5Hospira Reports Third-Quarter 2011 Results 6Hospira Reports Third-Quarter 2011 Results 7Hospira Reports Third-Quarter 2011 Results 8Hospira Reports Third-Quarter 2011 Results 9Hospira Reports Third-Quarter 2011 Results 10Hospira Reports Third-Quarter 2011 Results 11Hospira Reports Third-Quarter 2011 Results 12Hospira Reports Third-Quarter 2011 Results 13Hospira Reports Third-Quarter 2011 Results 14Hospira Reports Third-Quarter 2011 Results 15Hospira Reports Third-Quarter 2011 Results 16Hospira Reports Third-Quarter 2011 Results 17Hospira Reports Third-Quarter 2011 Results 18Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 2Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 3Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 4Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 5Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 6Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 7Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 8Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 9Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 10Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 11Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 12Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 13Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 14Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 15Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 16Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 17Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 18Wheelchair Market Shares, Strategies, and Forecasts, Worldwide, 2009 to 2015 19
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: