Navigation Links
Study proposes new ovarian cancer targets
Date:3/13/2014

n ovarian cancer. TAF2 amplifications, copy number gains, and expression increases are present in 73 percent of tumors. TAF4 is amplified or upregulated in 66 percent of tumors, and TAF4B is amplified or upregulated in 26 percent. TAF9, meanwhile, is rendered significantly less expressed in 98 percent of ovarian tumors.

The ups and downs of TAF expression alone might not be that interesting if TAF activity didn't have any mechanistic influence in cancer cell biology. But in her review of scores of studies and further original research, Ribeiro presents reasons to believe that in specific tissues and contexts around the body, these TAFs take on roles that are relevant.

"They are not just general transcription factors," Freiman said. "They do much more specific things."

The worst tumors are ones in which cells have "dedifferentiated," which means they've lost their specific identities and reverted to a more generic, stem cell-like form. Sure enough, Ribeiro and Freiman have found that TAFs such as TAF4 and TAF4B are downregulated when stem cells differentiate. That makes their upregulation in ovarian tumors suspicious.

TAF4B also emerges as a cancer suspect in the study because of its apparent role in promoting cell proliferation, a major problem in the runaway cell multiplication in tumors. Lindsay Lovasco, a postdoctoral fellow at Brown and second author of the study, ran an experiment in mouse models where she removed some of the liver and measured whether TAFs expression changed while the tissue regenerated. Expression of Taf4b (the gene in mice) did increase significantly. Also, in human ovarian granulosa cell-derived tumors, in collaboration with Dr. Barbara Vanderhyden at the University of Ottawa, Ribeiro found that TAF4B expression correlates strongly with Cyclin D2 expression, a protein that specifically promotes granulosa cell proliferation.

Even more suspicion falls on TAF4B based on Ribeiro's finding published l
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study proposes new ovarian cancer targets
(Date:2/27/2015)... 2015 Educators and dignitaries gathered February ... Year. The gala recognized the dedicated, exceptional teachers for ... in and outside of the classroom. One, Maggie Mabery, ... Middle School, was nominated as California’s National Teacher of ... of the California Department of Education’s School Recognition Program, ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 Aligned ... five local neighborhood health centers, officially welcomes Dr. ... Medicine based in Aligned Modern Health’s Lincoln Square, ... graduated from the National University of Health Sciences ... Award. She has completed post-graduate coursework in ...
(Date:2/27/2015)... 27, 2015 According to the ... than 38 million children and adolescents participate in ... As a result of this growing number, new ... equipment and square footage creating a need for ... , "Athletic facilities are hosting a ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 Marketresearchreports.biz has ... to its huge database of market studies that presents ... for the period of 2015-2019. The research report talks ... of the sports medicine devices industry across the globe. ... Medicine Devices Market 2015-2019”, the global sports medicine devices ...
(Date:2/27/2015)... February 27, 2015 Lewis Clinic Dentistry has ... to 4PM to make its services available for patients who ... spokesperson from the Lewis Clinic Dentistry said, “Yes, we have ... us on weekdays due to their busy schedules and work ... is to make more people’s lives beautiful and smiling.” He ...
Breaking Medicine News(10 mins):Health News:California Casualty is Presenting Sponsor of California Program Honoring Educators That Make a Difference 2Health News:California Casualty is Presenting Sponsor of California Program Honoring Educators That Make a Difference 3Health News:Chicago Wellness Centers Welcomes New Lead Functional Medicine Doctor to Staff 2Health News:Chicago Wellness Centers Welcomes New Lead Functional Medicine Doctor to Staff 3Health News:Rise of Students Participating in Sports Creates Need for Preventative Maintenance to Gymnasium Equipment in Athletic Facilities 2Health News:Rise of Students Participating in Sports Creates Need for Preventative Maintenance to Gymnasium Equipment in Athletic Facilities 3Health News:Global Sports Medicine Devices Market Benefitting from Significant Contribution from Arthroscopy Segment: MarketResearchReports.Biz 2Health News:Global Sports Medicine Devices Market Benefitting from Significant Contribution from Arthroscopy Segment: MarketResearchReports.Biz 3Health News:Lewis Clinic Dentistry Extends Business Hours 2
... NORTH DALLAS, Texas and PLANO, Texas, March 10 ... be the long-term wrinkle,solution for you!, Newly-FDA ... Texas and is already making waves -- radiofrequency ... and cosmetic surgery offices. GFX is a,unique technological ...
... The Women,s Dermatologic,Society (WDS) is pleased to announce ... office at the recent WDS luncheon during the,American Academy ... moved into the presidential role from this past year,s ... past three years.,Mary P. Lupo, MD, served as the ...
... In the hands of jewelers, gold can be fashioned ... reduced in size to nanocrystals containing a few thousand ... Finding the key to golds chemical reactivity (or that ... measurement techniques work at the nanoscale. Now, researchers at ...
... Hour, (http://www.giveanhour.org ), a non-partisan, non-profit organization offering ... loved ones,announces that there are now 1,000 providers, ... to supplement the mental health services already provided,to ... Give an Hour,s,services are available to the service ...
... insurance programs do not provide coverage to international ... ... Seven Corners, one of the,industry,s most experienced travel health insurance providers, ... to travel abroad for spring break vacations. Most health insurance,programs do ...
... Encourage Students to Pursue Careers in Veterinary ... ... ideal time to,enter the field of veterinary medicine. U.S. employment opportunities for,veterinarians ... the year 2012. California, alone, will need more,than 700 new veterinarians per ...
Cached Medicine News:Health News:GFX: Wrinkle-Killer or Botox(R) Hit-Man? 2Health News:GFX: Wrinkle-Killer or Botox(R) Hit-Man? 3Health News:Suzanne M. Connolly, MD Named 2008-2009 President of Women's Dermatologic Society 2Health News:Measurement technique probes surface structure of gold nanocrystals 2Health News:1,000 Mental Health Professionals Join National Network to Provide Free Counseling to Returning Veterans and their Families 2Health News:Seven Corners Alerts Spring Breakers that They Need Travel Insurance to Vacation Abroad 2Health News:Seven Corners Alerts Spring Breakers that They Need Travel Insurance to Vacation Abroad 3Health News:Shortage Creates Increased Job Prospects in Veterinary Medicine 2Health News:Shortage Creates Increased Job Prospects in Veterinary Medicine 3
(Date:2/26/2015)... 27, 2015  Finesse expands office in Leicester, ... the expansion of its operations in Leicester ... and access for customers is expected shortly afterward. ... adjacent to the current office, the new premises will ... and allow Finesse to bring on more service personnel. ...
(Date:2/26/2015)... Feb. 26, 2015  Today the National Safety ... psychological and physical side effects of pain medications ... such as Vicodin and Oxycontin, are safer options than ... on prescription painkillers than on heroin and cocaine combined," ... of NSC. "Yet, these medications are marketed as the ...
(Date:2/26/2015)... WASHINGTON , Feb. 26, 2015 Legislation ... includes a pharmacy provision to help prevent inappropriate prescriptions ... The Protecting the Integrity of Medicare Act (PIMA) ... Subcommittee Chairman Kevin Brady (R-TX) and Ranking ... the prescription drug abuse epidemic and implement the right ...
Breaking Medicine Technology:New Finesse Office in United Kingdom 2National Safety Council: Opioid prescription painkillers have hidden, deadly side effects 2PCMA Statement on the 'Protecting the Integrity of Medicare Act' 2
... , , COLLEGEVILLE, Pa., July ... of Wyeth (NYSE: WYE ), announced the publication ... Phase 3 clinical study that showed that the investigational compound ... hot flushes and improved measures of vaginal atrophy when compared ...
... , LOUISVILLE, Ky., July 24 In ... treatment of heart failure, we failed to make a critical ... phase-one FDA-approved clinical trial using "c-kit-positive" adult cardiac stem cells ... by a team of University of Louisville physicians at Jewish ...
Cached Medicine Technology:Wyeth Reports Publication of Phase 3 Data for Bazedoxifene/Conjugated Estrogens, an Investigational Compound Being Studied for the Treatment of Menopausal Symptoms 2Wyeth Reports Publication of Phase 3 Data for Bazedoxifene/Conjugated Estrogens, an Investigational Compound Being Studied for the Treatment of Menopausal Symptoms 3Wyeth Reports Publication of Phase 3 Data for Bazedoxifene/Conjugated Estrogens, an Investigational Compound Being Studied for the Treatment of Menopausal Symptoms 4Wyeth Reports Publication of Phase 3 Data for Bazedoxifene/Conjugated Estrogens, an Investigational Compound Being Studied for the Treatment of Menopausal Symptoms 5Wyeth Reports Publication of Phase 3 Data for Bazedoxifene/Conjugated Estrogens, an Investigational Compound Being Studied for the Treatment of Menopausal Symptoms 6
... shelves. Over-sized compressor. Triple pane thermal ... Self-Contained System No plumbing required. Equipped ... Year Warranty on Parts & Labor and an ... Also available as a chromatography unit which includes ...
... Large Capacity Refigerators from Taylor-Wharton enables you ... samples at liquid-nitrogen temperature. Seven different unit ... are available to satisfy a broad range ... models are also available, providing reduced unit ...
... Basic ergonomic chairs with concave seats ... • Select options like seats, backrests, ... BTP/1Q-PAL chairs are recommended for the ... room, static control, health care and ...
... Basic ergonomic chairs with concave ... support • Select options like seats, ... • BTP/1Q-PAL chairs are recommended for ... clean room, static control, health care ...
Medicine Products: