Navigation Links
Study paves way to design drugs aimed at multiple protein targets at once
Date:12/12/2012

g targets simultaneously. This paper provides a way to do that," Roth said.

The new way involves automated drug design by computer that takes advantage of large databases of drug-target interactions. The latter have been made public through Roth's lab at UNC and through other resources.

Basically, the researchers, also co-led by Andrew L. Hopkins, PhD in the Division of Biological Chemistry and Drug Discovery, College of Life Sciences, at the University of Dundee, in Scotland, used the power of computational chemistry to design drug compounds that were then synthesized by chemists, tested in experimental assays and validated in mouse models of human disease.

The study team experimentally tested 800 drug-target predictions of the computationally designed compounds; of these, 75 percent were confirmed in test-tube (in vitro) experiments.

Drug to target engagement also was confirmed in animal models of human disease. In a mouse model of attention deficit hyperactivity disorder (ADHD), mice missing a particular dopamine receptor engage in recurrent aberrant behaviors similar to what is seen in ADHD: distractibility and novelty seeking. "We created a compound that was predicted to prevent those recurrent behaviors and it worked quite well," Roth said.

The researchers then tested the compound in another mouse model where a particular enzyme for a brain neuropeptide is missing. Distractibility and novelty seeking also are behavioral features in these animals. And the drug had the same effect in those mice.

The new drug design process includes ensuring that compounds enter the brain by crossing the blood-brain barrier. These, too, were tested successfully in live animals.

According to Roth, pharmaceutical company chemists had suggested that the objective of a drug hitting multiple targets simultaneously is impossible and unlikely to succeed. "Here we show how to efficiently and effectively make designer drugs
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina Health Care
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Targeted micro-bubbles detect artery inflammation, MU study finds
2. Study Finds New SARS-Like Virus Spread Through Bats, Pigs
3. Junk Food Taxes Pay Off, Study Finds
4. Brain Changes Continue After Childs Concussion: Study
5. Even Light Smoking Boosts Womens Risk of Sudden Heart Death: Study
6. Primary Care Doctors Meet Needs of Diabetics, Study Says
7. Avastin Shows No Benefit for Earlier Colon Cancer: Study
8. Regular Exercise May Add Years to Life, Study Finds
9. Coffee May Lower Risk of Death From Mouth Cancer: Study
10. RSNA: New Study Finds Brain Angioplasty and Stents Safe and Effective for Stroke Patients
11. Salmonella spreads by targeting cells in our gut, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study paves way to design drugs aimed at multiple protein targets at once
(Date:8/22/2014)... 22, 2014 Dealing with a drug or ... the addict is a child. Adolescent substance abuse has been ... long time. But a new helpline is now providing a ... youth rehab for something like a teen drug addiction ... to help make a positive impact in the community. By ...
(Date:8/22/2014)... According to the market research report "Blind ... (ACC) System Market for Passenger Cars; by Geography ... by MarketsandMarkets, classifies and defines the automotive BSD ... and value. The report highlights potential growth opportunities ... review of the market drivers, restrains, growth indicators, ...
(Date:8/21/2014)... Petersburg, FL (PRWEB) August 22, 2014 The ... behind those fine lines, wrinkles and sagging of skin. ... loss. , "By age 40, the body has lost about ... has lost about 45%," says Kathy Heshelow, founder of Sublime ... with less of it - well, we know what happens." ...
(Date:8/21/2014)... York, NY (PRWEB) August 21, 2014 ... can often have larger discounts for specific protection plans, ... is now helping consumers to quote life insurance from ... , The local agents that appear inside of ... offer a fast method of price reviews this year. ...
(Date:8/21/2014)... 21, 2014 AVEC Health Solutions, ... the addition of Kerry Gillespie as Chief Executive ... management experience, Gillespie brings an extremely robust background ... management positions with prominent industry leading organizations across ... President of Triad Isotopes, Inc. a private nuclear ...
Breaking Medicine News(10 mins):Health News:Cincinnati’s New Troubled Teen Helpline is Making a Difference in the Community 2Health News:Automotive Blind Spot Detection System Market Worth $2.8 Billion and Automotive Adaptive Cruise Control System Market Worth $6.1 Billion by 2019 – New Report 2Health News:Automotive Blind Spot Detection System Market Worth $2.8 Billion and Automotive Adaptive Cruise Control System Market Worth $6.1 Billion by 2019 – New Report 3Health News:Automotive Blind Spot Detection System Market Worth $2.8 Billion and Automotive Adaptive Cruise Control System Market Worth $6.1 Billion by 2019 – New Report 4Health News:4 Skincare Products That Boost and Nurture Collagen on Sale at Sublime Beauty® 2Health News:4 Skincare Products That Boost and Nurture Collagen on Sale at Sublime Beauty® 3Health News:Life Insurance from Local Agents Now Priced Nationally Through Complimentary Tool Online 2Health News:Kerry Gillespie Appointed as Chief Executive Officer of AVEC Health Solutions 2
... was issued,today by the law firm of Schiffrin Barroway Topaz ... class action lawsuit was filed in the,United States District Court ... of securities of Healthways Inc. (Nasdaq: HWAY ),("Healthways" or ... (the "Class Period")., If you wish to discuss this ...
... The University of Illinois at Chicago is one of ... Norway to participate in the Clinical Islet Transplant Consortium ... researchers have begun clinical studies to test new approaches ... and fewer side effects for adults with difficult-to-control type ...
... U.S. Senate to vote soon on legislation that ... New Hampshire, WASHINGTON, July 8 Seniors ... to the Medicare Advantage,program in legislation being considered ... cut $6.6 million from the Medicare Advantage program ...
... Pittsburgh-led researchers could provide new insight into how ... arteriovenous malformations (AVMs)develop in humans, as reported in ... . , Led by Beth Roman, an assistant ... Arts and Sciences, the team created the first ...
... rates no different than ,watchful waiting, study shows , , ... therapy used for localized prostate cancer may not bestow ... with a simple "wait-and-see" approach. , Men taking androgen ... promote tumor growth, even had a slightly lower ...
... From the Committee to Reduce Infection Deaths (RID), ... to be,proud of," says Betsy McCaughey, Chairman of the ... of New York State. The New York,State Hospital-Acquired Infection ... performance with national infection,rate averages, and finds the state ...
Cached Medicine News:Health News:Shareholder Class Action Filed Against Healthways Inc. By The Law Firm of Schiffrin Barroway Topaz & Kessler, LLP 2Health News:Shareholder Class Action Filed Against Healthways Inc. By The Law Firm of Schiffrin Barroway Topaz & Kessler, LLP 3Health News:UIC in NIH-funded islet transplantation study for type 1 diabetes 2Health News:New Hampshire Seniors Speak Out Against Medicare Advantage Cuts 2Health News:Pitt-led research provides insight into development of congenital circulatory defects 2Health News:Hormone Therapy Shows Little Benefit Against Prostate Cancer 2Health News:Hormone Therapy Shows Little Benefit Against Prostate Cancer 3Health News:It's the Same Old Song: 'Accentuate the Positive' as New York State Department of Health Releases Statewide Hospital Infection Rates 2
(Date:8/21/2014)... Germany , Aug. 21, 2014  IBM (NYSE: ... Elektronen-Synchrotron ( DESY ), a leading national research center ... management and storage of massive volumes of x-ray data. ... based on IBM software defined technology can handle more ... performance and help scientists worldwide gain faster insights into ...
(Date:8/21/2014)... of Americans believe the abuse of strong prescription pain medications ... issue in the United States , according ... Partners, a Cincinnati based research firm. ... prescription medication abuse problem and the need for medical innovation ... our country," Rex Repass , CEO of the survey ...
(Date:8/21/2014)... BreedIT Corp., (OTCQB: BRDT) ... worldwide license holder and distributor of highly sophisticated ... today is pleased to announce the formation of ... a leading Israeli medical Cannabis breeder. ... breeds of medical Cannabis to meet the requests ...
Breaking Medicine Technology:DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3Consumers Desperate For Measures To Curb Prescription Drug Abuse 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 4
... SAN DIEGO , May 3 The Wireless-Life ... and policy makers to drive improved healthcare through advances in wireless technologies, ... WLSA,s mission. , , , ... http://www.newscom.com/cgi-bin/prnh/20100428/LA95139LOGO ) , , , ...
... 3 Simmons Browder Gianaris Angelides & ... the resolution of their client Synergetics USA, Inc.,s (Nasdaq: ... Alcon, Inc.  Synergetics announced on April 27, 2010 , ... and a Supply Agreement with Alcon, pursuant to which all ...
Cached Medicine Technology:Wireless-Life Sciences Alliance (WLSA) Applauds Partner Organizations for Supporting Goal of Improving Healthcare Via Wireless Technologies 2Wireless-Life Sciences Alliance (WLSA) Applauds Partner Organizations for Supporting Goal of Improving Healthcare Via Wireless Technologies 3Simmons Firm Announces Settlement of Contingent Fee Antitrust Lawsuit 2Simmons Firm Announces Settlement of Contingent Fee Antitrust Lawsuit 3
Clip-On Glasses clip onto regular eyewear frames. Plano (nonprescription) only. Will not fit over high-plus or high-minus presciptions, or over glasses with thick frames. Black wire frames. Wt. 63 g....
Portable shields for your safety and convenience....
Manufactured with large, shatter-resistant Clear Pb leaded acrylic panels which provide a wide field of vision for one or more users. Opaque lower panels are covered in your choice of decorative viny...
... protection during diagnostic procedures such ... spine. Includes a durable nylon ... 36" - 60". Rolls on ... for extra stability and easy ...
Medicine Products: