Navigation Links
Study participants at risk for Alzheimer's want to know their potential fate

ANN ARBOR, Mich.If you had a family history of developing Alzheimer's disease, would you take a genetic test that would give you more information about your chances?

"Definitely," said Gloria VanAlstine, 60, and Joyce Smith, 79. The two women took a controversial genetic test of a gene called Apolipoprotein E. APOE is a susceptibility gene where certain variants have been found to significantly increase a person's risk of developing Alzheimer's disease. Both women have a family history of Alzheimer's, which increases risk.

The genetic test was conducted as part of the Risk Evaluation and Education for Alzheimer's disease Study (REVEAL), a series of clinical trials taking place at U-M School of Public Health, with other sites including Harvard University, Howard University, and the University of Pennsylvania.

APOE testing is controversial in the medical community because the variant is neither necessary nor sufficient to cause Alzheimer's disease. This limitation, along a with a general lack of treatment options for Alzheimer's, has raised concerns that the genetic information could burden rather than benefit patients. There have been numerous consensus statements and articles against using APOE genotyping for predicting Alzheimer's risk.

However, most of the study participants who took the test, including VanAlstine and Smith, wanted to learn about their APOE test results and were not overtly distressed by them, said Scott Roberts, associate professor in U-M SPH, and co-principal investigator of REVEAL, along with Robert Green at Harvard University School of Medicine.

The National Society of Genetic Counselors and American College of Medical Genetics recently developed practice guidelines for genetic counseling and testing for Alzheimer's disease. Roberts is one of the authors.

The guidelines provide clinicians with a framework for assessing their patients' genetic risk for Alzheimer's disease, identifying which individuals may benefit from genetic testing, and providing the key elements of genetic counseling. Alzheimer's disease is traditionally subdivided into early onset and late onset types. Early onset occurs before age 60-65 years and accounts for 1 to 5 percent of all cases, while late onset occurs after 60-65 years and is the predominant form.


Contact: Laura Bailey
University of Michigan

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping ... fitness app. The fitness app plans to fix the two major problems leading the fitness ... size fits all type program , They don’t eliminate all the reasons people ...
(Date:6/25/2016)... ... 25, 2016 , ... Austin residents seeking Mohs surgery services, can now turn ... to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization ... selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set ... drug or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, ... traumatic event. , Trauma sufferers tend to feel a range of emotions, from depression, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CHAPEL HILL, N.C. , June 24, 2016 ... in healthcare decisions and regulators/payers have placed more ... this new environment, patient support programs in the ... support for patients, medications. Consequently, pharmaceutical companies are ... to ensure they are providing products and services ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... and Markets has announced the addition of the ... their offering. ... products and provides an updated review, including its applications ... covering the total market, which includes three main industries: ...
(Date:6/24/2016)... ANDOVER, Mass. and SAN CLEMENTE, Calif. ... California -based mobile pulmonary function testing company, is now ... portable PFT devices developed by ndd Medical Technologies , Inc. ... PFT testing done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ... CA , can get any needed testing done in the ...
Breaking Medicine Technology: