Navigation Links
Study participants at risk for Alzheimer's want to know their potential fate
Date:12/12/2011

ANN ARBOR, Mich.If you had a family history of developing Alzheimer's disease, would you take a genetic test that would give you more information about your chances?

"Definitely," said Gloria VanAlstine, 60, and Joyce Smith, 79. The two women took a controversial genetic test of a gene called Apolipoprotein E. APOE is a susceptibility gene where certain variants have been found to significantly increase a person's risk of developing Alzheimer's disease. Both women have a family history of Alzheimer's, which increases risk.

The genetic test was conducted as part of the Risk Evaluation and Education for Alzheimer's disease Study (REVEAL), a series of clinical trials taking place at U-M School of Public Health, with other sites including Harvard University, Howard University, and the University of Pennsylvania.

APOE testing is controversial in the medical community because the variant is neither necessary nor sufficient to cause Alzheimer's disease. This limitation, along a with a general lack of treatment options for Alzheimer's, has raised concerns that the genetic information could burden rather than benefit patients. There have been numerous consensus statements and articles against using APOE genotyping for predicting Alzheimer's risk.

However, most of the study participants who took the test, including VanAlstine and Smith, wanted to learn about their APOE test results and were not overtly distressed by them, said Scott Roberts, associate professor in U-M SPH, and co-principal investigator of REVEAL, along with Robert Green at Harvard University School of Medicine.

The National Society of Genetic Counselors and American College of Medical Genetics recently developed practice guidelines for genetic counseling and testing for Alzheimer's disease. Roberts is one of the authors.

The guidelines provide clinicians with a framework for assessing their patients' genetic risk for Alzheimer's disease, identifying which individuals may benefit from genetic testing, and providing the key elements of genetic counseling. Alzheimer's disease is traditionally subdivided into early onset and late onset types. Early onset occurs before age 60-65 years and accounts for 1 to 5 percent of all cases, while late onset occurs after 60-65 years and is the predominant form.


'/>"/>

Contact: Laura Bailey
baileylm@umich.edu
734-764-1552
University of Michigan
Source:Eurekalert

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... ... January 19, 2017 , ... WholeHealth is announcing ... Drs. Alexander Paziotopoulos, Andrew Petersen and Trish Henrie-Barrus will be present Saturday and ... leading recovery program. , “We know it’s easy to get carried away ...
(Date:1/19/2017)... ... January 19, 2017 , ... MB Business Capital, a division ... credit facility to Sunrise, Florida-based Management Health Systems, LLC, dba MedPro Healthcare Staffing ... recapitalization of MedPro led by Harren Equity Partners. Brightwood Capital Advisors provided ...
(Date:1/19/2017)... ... January 19, 2017 , ... Students interested in video can get a ... The winner will earn a $1,000 scholarship and have his or her video posted ... the deadline is May 31, with the winner announced on June 9. , The ...
(Date:1/19/2017)... ... January 19, 2017 , ... Ultimate Medical Academy (UMA) is ... passionate about making a difference in the lives of the next generation of ... nonprofit healthcare educational institution, has more than 30,000 alumni and employs more than ...
(Date:1/19/2017)... ... January 19, 2017 , ... Rountree Brady ... services to communities throughout eastern Georgia, is embarking on a charity effort to ... disease kills more Americans every year than anything else, yet risk factors associated ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... -- Research and Markets has announced the addition of the ... Global Opportunity Analysis and Industry Forecast, 2014-2022" report to their offering. ... Vital signs monitoring market ... $5,491 million by 2022, growing at a CAGR of 5.8% from 2016 ... the leading regional market in global vital signs monitoring devices industry. The ...
(Date:1/18/2017)... Jan. 18, 2017  Adaptive Sound Technologies, Inc. (ASTI), the ... partnership with Hyatt Place Nashville/Downtown to deliver the best ... sleep therapy machines in over two hundred of its ... important parts of having a great stay is sleeping ... Hyatt Place Nashville/Downtown. "We,re pleased to be able to ...
(Date:1/18/2017)... , Jan. 18, 2017   Regenicin, Inc. ... biotechnology company specializing in the development and commercialization of ... tissues and organs, recently reported the Company,s operating results ... 2017. As the Company described in its ... a year of substantial accomplishments. The Company,s contract laboratory ...
Breaking Medicine Technology: