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Study offers new way to discover HIV vaccine targets
Date:3/21/2013

exposed to the virus but able to control it without medication. Immune cells in those people target the same peptide sequences that the model predicted would produce the biggest loss of fitness when mutated.

This general approach could also be used to identify vaccine targets for other viruses, Chakraborty says.

"The reason we are excited about this is that we now have a method that combines two technologies that are getting cheaper all the time: sequencing and computation," he says. "We think that if this continues to be validated, it could become a general method of obtaining the fitness landscapes of viruses, allowing you to do rational design of the active components of vaccines."

"This work is a great example of how integrating expertise from different scientific disciplines in this case physics, computational biology, virology and immunology can accelerate progress toward an HIV vaccine," Walker says.


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Contact: Kimberly Allen
allenkc@mit.edu
617-253-2702
Massachusetts Institute of Technology
Source:Eurekalert

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