Navigation Links
Study offers new way to discover HIV vaccine targets
Date:3/21/2013

s derived from Gag are important structural elements of the virus. For example, a protein called p24 makes up the capsid that surrounds the virus's genetic material.

Each position in HIV proteins can be occupied by one of 20 possible amino acids. Sequence data from thousands of different HIV strains contain information on the likelihood of mutations at each position and each pair of positions, as well as for triplets and larger groups. The researchers then developed a computer model based on spin glass models, originally developed in physics, to translate this information into predictions for the prevalence of any mutant.

Using this model, the researchers can enter any possible sequence of Gag proteins and determine how prevalent it will be. That prevalence correlates with the fitness of a virus carrying that particular protein sequence, a relationship that the researchers demonstrated by using the model to predict the fitness of a few dozen Gag protein sequences, and verified by engineering those sequences into HIV viruses and testing their ability to replicate in cells grown in the lab. They also tested their predictions against human clinical data.

Visualizing fitness

The model also allows the researchers to visualize viral fitness using "fitness landscapes" topographical maps that show how fit the virus is for different possible amino-acid sequences for the Gag proteins. In these landscapes, each hill represents sequences that are very fit; valleys represent sequences that are not.

Ideally, vaccine-induced immune responses would target viral proteins in such a way that mutant strains that escape the immune response correspond to the fitness valleys. Thus, the virus would either be destroyed by the immune response or forced to mutate to strains that cannot replicate well and are less able to infect more cells.

This would mimic the immune response mounted by people known as "elite controllers," who are
'/>"/>

Contact: Kimberly Allen
allenkc@mit.edu
617-253-2702
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Scripps Research study underlines potential of new technology to diagnose disease
2. Suicidal Thoughts More Common in Kids With Autism: Study
3. Most of Worlds Adults Consume Too Much Salt, Study Finds
4. Genetic risk strategies needed for young, black, female breast cancer patients, Moffitt study shows
5. Brain Changes Could Contribute to Gulf War Illness: Study
6. Study Reveals Weight Loss Supplement Prescopodene Increases Weight Loss By As Much As 9 Times
7. Moffitt Cancer Center researchers study use of dasatinib for patients with high-risk MDS
8. Zinga! Frozen Yogurt Touts Harvard Study for National Nutrition Month
9. Study reveals potential immune benefits of vitamin D supplements in healthy individuals
10. Women Abused in Childhood at Higher Odds of Having Child With Autism: Study
11. Blacks More Likely to Get Amputations Due to Blocked Blood Flow: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... (PRWEB) January 22, 2015 The federal court ... the U.S. District Court, Southern District of West Virginia has ... in that proceeding’s first bellwether trial. In an Order dated ... new trial after finding that C.R. Bard had not proven ...
(Date:1/22/2015)... 2015 Thousand of GranuFlo lawsuits ( ... its GranuFlo and NaturaLyte dialysis concentrates continue to move ... District Court, District of Massachusetts, Bernstein Liebhard LLP reports. ... has remanded a case filed by the state of ...
(Date:1/22/2015)... 2015 Carinsurancesavings.biz has released a new blog ... dismemberment insurance . , Purchasing an accidental death and ... advantageous. This type of rider provides benefits if the insured ... considered a lesser form of life insurance. , AD&D ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Yesterday, ... Bonilla (D-Concord) and Kristin Olsen (R-Modesto) were honored ... leadership in advancing biotechnology, biomedical science, medical device ... Olsen each received the “2014 Life Sciences Champion” ...
(Date:1/22/2015)... Four years since the release of their debut ... the marriage of Avasa & Matthew Love – the duo are ... for release through White Swan Records on February 24, 2015. , ... sacred path available to all of us to walk out of ...
Breaking Medicine News(10 mins):Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4
... News) -- Scientists have identified common genetic variations that may ... Vitamin E is an antioxidant found in a number of ... as peppers, tomatoes and pumpkins. Previous research has found that ... the vitamin in a person,s body. It,s been suspected that ...
... October, 2010 Elsevier / MC Strategies, a pioneer ... organizations, has partnered with the Association of periOperative Registered ... Nursing Skills: Perioperative Collection, the only perioperative-specific set of ... with the Standards and Recommended Practices. ...
... (SFMU) has chosen Springer to publish its scientific research ... mdecine d,urgence . Bruno Riou, Professor on the Pierre ... Universities is editor-in-chief of this official society journal. ... d,urgence is targeted at the community of French ...
... , WEDNESDAY, Oct. 20 (HealthDay News) -- In ... your adaptability and resilience, a new study suggests. Researchers ... national survey each year from 2001 to 2004. Those who ... than those exposed to high levels of adversity or no ...
... GOLDEN, Colo. (October 20, 2010) A new independent study ... patients at 5-star rated hospitals had a 72% lower risk ... an enormous gap that has held steady over the past ... the study, if all hospitals performed at the level of ...
... , TUESDAY, Oct. 19 (HealthDay News) -- Men with ... death from heart disease and all causes, a finding that ... for cardiovascular disease, according to new research. The study ... for about seven years. At the start of the study, ...
Cached Medicine News:Health News:Elsevier/MC Strategies and AORN launch perioperative nursing skills collection 2Health News:New ratings of American hospitals released with quality study by HealthGrades 2Health News:New ratings of American hospitals released with quality study by HealthGrades 3Health News:Low Testosterone May Raise Risk of Early Death: Study 2
(Date:1/23/2015)... BOSTON , January 23, 2015 Heptares ... is delighted to announce that the Malcolm Campbell ... Congreve (Vice President of Chemistry), Fiona Marshall ... (Chief Executive Officer and co-founder) for the seminal contributions to ...
(Date:1/22/2015)... Inc. (NYSE: RMD ) today announced results for ... was $423.0 million, a 10 percent increase compared to the ... a constant currency basis). Net income was $91.2 million, an ... 31, 2013. Diluted earnings per share for the quarter were ...
(Date:1/22/2015)... Calif. , Jan. 22, 2015 Increasing sophistication ... continued consolidation of localization purchasing in 2015, says ... According to a recent study by market research firm ... a single-source solution for their translation and localization needs. ...
Breaking Medicine Technology:Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 11Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2
... announced yesterday that most of Kentucky,s Medicaid program would ... million. In modernizing the state,s Medicaid pharmacy benefits, the ... benefit managers (PBMs) to lower prescription drug costs, the ... "Governor Beshear has done the right thing for ...
... July 8, 2011 As the economy recovery continues ... increase competition and reduce health care costs. Running counter ... agenda that takes away employers, ability to save money ... medications, the Pharmaceutical Care Management Association (PCMA) said today. ...
Cached Medicine Technology:Modernizing Medicaid Rx with 'Innovative' PBM Tools Will Help Kentucky Save $375 Million 2As Economic Recovery Sputters, Independent Drugstores Shouldn't Shoulder Employers With Higher Costs 2
... The Olympus SurgMaster OES Pro Resectoscope is ... Pro standard resectoscope and enables the surgeon ... Only by exchanging the working element, HF ... can be upgraded for resection in saline, ...
... drainage from the ureteropelvic junction to the ... ease of placement and patient compliance. The ... repositioning and ease of removal. AQ® is ... when activated, attracts and holds water and ...
... comprises a PC-based ECG device that ... treadmill and an innovative software. The ... ECG recording using a standard 12-lead ... patient. The software includes two applications: ...
... PRECISION represents a major advance in ... focused to cover pain. This is ... you need it, anywhere along the ... independent current sources for each of ...
Medicine Products: