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Study offers new theory of cancer development
Date:10/31/2013

ssor of biology at Massachusetts Institute of Technology who was not involved in the project. "These novel algorithms of identifying tumor suppressors and oncogenes nicely provide an explanation of how aneuploidies evolve in cancer cells, and the realization that subtle changes in the activity of many different genes at the same time can contribute to tumorigenesis is an exciting and intriguing hypothesis."

These findings also may have answered a long-standing question about whether aneuploidy is a cause or effect of cancer, leaving researchers free to pursue the question of how.

"Aneuploidy is driving cancer, not simply a consequence of it," said Elledge. "Other things also matter, such as gene mutations, rearrangements and changes in expression. We don't know what the weighting is, but now we should be able to figure it out."

Going forward, Elledge and Davoli plan to gather experimental evidence to support their mathematical findings. That will include validating some of the new predicted tumor suppressors and oncogenes as well as "making some deletions and amplifications and seeing if they have the properties we think they do," said Elledge.


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Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

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