Navigation Links
Study offers new theory of cancer development
Date:10/31/2013

For more than 100 years, researchers have been unable to explain why cancer cells contain abnormal numbers of chromosomes, a phenomenon known as aneuploidy. Many believed aneuploidy was simply a random byproduct of cancer.

Now, a team at Harvard Medical School has devised a way to understand patterns of aneuploidy in tumors and predict which genes in the affected chromosomes are likely to be cancer suppressors or promoters. They propose that aneuploidy is a driver of cancer rather than a result of it.

The study, to be published online in Cell on Oct. 31, offers a new theory of cancer development and could open the door for new treatment targets.

"If you look at a cancer cell, it looks like an unholy mess with gene deletions and amplifications, chromosome gains and losses, like someone threw a stick of dynamite into the cell. It seems random, but actually previous work has shown that there is a pattern to which chromosomes and chromosome arms are alteredand that means we can understand that pattern and how or if it drives cancer," said senior author Stephen Elledge, Gregor Mendel professor of Genetics and of Medicine at HMS and professor of medicine at Brigham and Women's Hospital.

"What we have done is to propose a new theory about how this works and then prove it using mathematical analysis," he said.

Mining for answers

For decades since the "oncogene revolution," cancer research has focused on mutationschanges in the DNA code that abnormally activate genes that promote cancer, called oncogenes, or deactivate genes that suppress cancer. The role of aneuploidyin which entire chromosomes or chromosome arms are added or deletedhas remained largely unstudied.

Elledge and his team, including research fellow and first author Teresa Davoli, suspected that aneuploidy has a significant role to play in cancer because missing or extra chromosomes likely affect genes involved in tumor-related pro
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Lefties more likely to have psychotic disorders such as schizophrenia: Yale study
2. Unpublished trial data violates an ethical obligation to study participants, say researchers
3. ER study finds 1 in 10 older teens misuse Rx painkillers & sedatives
4. Male birth defect is weakly linked to pesticide exposure, Stanford-led study finds
5. RI Hospital study measures impact of education, information on hand hygiene compliance
6. Miriam Hospital researcher awarded $2.9 million NIH grant to study impact of maternal smoking
7. ER study finds 1 in 10 older teens misuse Rx painkillers & sedatives
8. New study: Enterocystoplasty in children with genitourinary abnormalities is safe and effective
9. New Study Confirms Patent Assertion Is a Growing and Costly Burden on Innovation Ecosystem
10. New study on neurodevelopmental effects of prenatal exposure to paracetamol
11. Study to assess impact of health reform in India
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... a famous wedding dress company offering many trendy designs. Today, ... Twitter, and Pinterest. The fans will have an opportunity to ... week. , Moreover, the company has extended its 2015 New ... for more information. , Angelweddingdress is a famous ...
(Date:1/22/2015)... 22, 2015 Juvent Sports ( http://www.juventsports.com ... 2015 PGA Merchandise Show to bestow a Juvent Sports ... amateur golfer, Arlene McKitrick. The award commemorated and congratulated ... tournament win. She won her first amateur tournament in ...
(Date:1/22/2015)... For over 20 years, Dr. David Cruz of ... area has treated just about every type of injury that can ... for those same twenty-plus years, the team at Doctors on ... the best possible doctor. With the combined breadth of ...
(Date:1/22/2015)... 2015 Yesterday, Senator Holly Mitchell ... Kristin Olsen (R-Modesto) were honored by the California ... biotechnology, biomedical science, medical device and pharmaceutical innovation ... the “2014 Life Sciences Champion” award from CHI ...
(Date:1/22/2015)... Payday lending practices in four southern states ... distress to the states that permit them, according to ... on Race and Wealth. , While they generate hundreds ... at the same time substantially depress economic activity, according ...
Breaking Medicine News(10 mins):Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2
... Tenn., Dec. 1 It is a cold December day ... and LPGA star Morgan Pressel have gathered here -- but ... of the biggest names in,professional golf to Memphis is something ... cancer. , (Photo: ...
... Quarter --, -- Fully ... ... TSX Venture Exchange: NVC , , RICHMOND, ... device company, today announced financial results for the third quarter and nine months ...
... PICK: Harnessing miRNA natural gene repressors for anticancer therapy ... Sloan-Kettering Cancer Center, New York, have developed a new ... purposes, and used this to mediate effective anticancer therapy ... miRNAs are powerful natural repressors of gene expression. In ...
... ViroPharma Incorporated,(Nasdaq: VPHM ) today announced that the ... Food and Drug Administration,(FDA) for Cinryze(TM) C1 Inhibitor (human) as ... The sBLA is based on ... acute treatment study of Cinryze and interim data from an ...
... ETHICON, Inc., a Johnson & Johnson company, announced ... Wound Care business to One Equity Partners. Financial terms ... , Under the terms of the transaction, ... portfolio, which contains such advanced wound care brands as PROMOGRAN ...
... and resources , , MONDAY, Dec. 1 (HealthDay ... a poor job safeguarding the nation,s food supply, the ... detailing its efforts to protect consumers. , Among the ... to build better relationships with state and local health ...
Cached Medicine News:Health News:More than 1,500 Eagles -- Each One with a Story: Eagles Made During PGA TOUR and LPGA Season Result in Record Donation to St. Jude 2Health News:More than 1,500 Eagles -- Each One with a Story: Eagles Made During PGA TOUR and LPGA Season Result in Record Donation to St. Jude 3Health News:More than 1,500 Eagles -- Each One with a Story: Eagles Made During PGA TOUR and LPGA Season Result in Record Donation to St. Jude 4Health News:More than 1,500 Eagles -- Each One with a Story: Eagles Made During PGA TOUR and LPGA Season Result in Record Donation to St. Jude 5Health News:More than 1,500 Eagles -- Each One with a Story: Eagles Made During PGA TOUR and LPGA Season Result in Record Donation to St. Jude 6Health News:More than 1,500 Eagles -- Each One with a Story: Eagles Made During PGA TOUR and LPGA Season Result in Record Donation to St. Jude 7Health News:Neovasc Inc. Reports Third Quarter Fiscal Year 2008 Financial Results 2Health News:Neovasc Inc. Reports Third Quarter Fiscal Year 2008 Financial Results 3Health News:Neovasc Inc. Reports Third Quarter Fiscal Year 2008 Financial Results 4Health News:Neovasc Inc. Reports Third Quarter Fiscal Year 2008 Financial Results 5Health News:Neovasc Inc. Reports Third Quarter Fiscal Year 2008 Financial Results 6Health News:Neovasc Inc. Reports Third Quarter Fiscal Year 2008 Financial Results 7Health News:Neovasc Inc. Reports Third Quarter Fiscal Year 2008 Financial Results 8Health News:Neovasc Inc. Reports Third Quarter Fiscal Year 2008 Financial Results 9Health News:Neovasc Inc. Reports Third Quarter Fiscal Year 2008 Financial Results 10Health News:Neovasc Inc. Reports Third Quarter Fiscal Year 2008 Financial Results 11Health News:JCI online early table of contents: Dec. 1, 2008 2Health News:JCI online early table of contents: Dec. 1, 2008 3Health News:JCI online early table of contents: Dec. 1, 2008 4Health News:ViroPharma Submits Supplemental Biologics License Application for Cinryze(TM) to Treat Acute Attacks of Hereditary Angioedema 2Health News:ViroPharma Submits Supplemental Biologics License Application for Cinryze(TM) to Treat Acute Attacks of Hereditary Angioedema 3Health News:ViroPharma Submits Supplemental Biologics License Application for Cinryze(TM) to Treat Acute Attacks of Hereditary Angioedema 4Health News:ViroPharma Submits Supplemental Biologics License Application for Cinryze(TM) to Treat Acute Attacks of Hereditary Angioedema 5Health News:ETHICON Completes Divestiture of Professional Wound Care Business to One Equity Partners 2Health News:ETHICON Completes Divestiture of Professional Wound Care Business to One Equity Partners 3Health News:FDA Touts Efforts to Enhance Food Safety 2Health News:FDA Touts Efforts to Enhance Food Safety 3Health News:FDA Touts Efforts to Enhance Food Safety 4
(Date:1/23/2015)... , Jan. 23, 2015 Gem Pharmaceuticals announced today ... been enrolled into the Company,s Phase 2 clinical trial. ... of Gem,s lead compound, GPX-150 (an investigational medication), in ... metastatic disease. Logo - http://photos.prnewswire.com/prnh/20150123/170966LOGO ...
(Date:1/22/2015)... a privately held medical device company, announced today that ... ITOCHU Corporation (Tokyo Stock Exchange TYO: 8001) to sell ... cancer in Japan . ViewRay,s technology, ... only MRI-guided radiation therapy system that images and treats ...
(Date:1/22/2015)... Jan. 22, 2015  ResMed Inc. (NYSE: RMD ) ... Revenue for the quarter was $423.0 million, a 10 percent ... 14 percent increase on a constant currency basis). Net income ... the quarter ended December 31, 2013. Diluted earnings per share ...
Breaking Medicine Technology:Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 11
... House Appropriations Committee Ranking Member Congressman Norm ... Member Congressman Adam Smith, senior House Ways and ... and Commerce Committee member Congressman Jay Inslee, sent ... Human Services Secretary Kathleen Sebelius urging the Department ...
... Researchers from the University of Cincinnati presented results from ... Society 2011 Annual Meeting today, demonstrating how PEM-guided ... for breast cancer patients.   PEM ... the location as well as the metabolic phase of ...
Cached Medicine Technology:Congressional Leaders Urge HHS Secretary to Approve Coding for Advanced Lower Limb Prosthetic Device, Smart Pyramid™ 2Study Shows Same Day PET-Guided Biopsy May Expedite Pre-Operative Work-up For Breast Cancer Patients and Reduce Radiation Exposure 2
... Short Instrument for applications in ... VERSASTEP™ Plus Short Instrument with ... a unique endoscopic entry device ... procedures. It is used to ...
... VERSASTEP™ Plus Long Instrument ... ,The VERSASTEP™ Plus Long ... is a unique endoscopic entry ... laparoscopic procedures. It is used ...
... The Open-Step™ single-use system device is comprised ... for creating each access port are also ... 12 mm locking cone with 12 mm ... sterile; The 12 mm locking cone ...
... The Step™ and Mini Step™ device components are ... Step™ Single Use System is supplied sterile in ... packaged in various configurations and combinations. They are ... Access needle and the Step™ radially Expandable Sleeve. ...
Medicine Products: