Navigation Links
Study offers clues to cause of kids' brain tumors
Date:11/16/2012

ll types helps explain why gliomas are most often found in the optic nerves and brainstem of children with NF1these areas are where the susceptible cell types reside.

With that in mind, Gutmann and his colleagues tested the effects of the unusual fusion BRAF protein in neural stem cells from the cerebellum, where sporadic pilocytic astrocytomas often form, and in cells from the cortex, where the tumors almost never develop.

"Abnormal BRAF only results in increased growth when it is placed in neural stem cells from the cerebellum, but not the cortex," Gutmann says. "We also found that putting fusion BRAF into mature glial cells from the cerebellum had no effect."

When fusion BRAF causes increased cell proliferation, postdoctoral fellows Aparna Kaul, PhD and Yi-Hsien Chen, PhD, showed that it activates the same cellular growth pathway, called mammalian target of rapamycin (mTOR), that is normally also controlled by the NF1 protein. An extensive body of research into the mTOR pathway already exists, including potential treatments to suppress its function in other forms of cancer.

"We may be able to leverage these insights and our previous work in NF1 to improve the treatment of these common pediatric brain tumors, and that's very exciting," Gutmann says.

Gutmann and his colleagues are now working to identify more of the factors that make particular brain cells vulnerable to the tumor-promoting effects of the NF1 gene mutation and fusion BRAF. They are also developing animal models of sporadic pilocytic astrocytoma for drug discovery and testing.


'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... June 19, 2013 Middle market merger ... across all industries as cash rich buyers seek to ... across industries, all M&A transactions have a good deal ... to verify the history and quality of the target ... , But when due diligence involves a middle market ...
(Date:6/18/2013)... June 19, 2013 oBand Surgery Centers, ... are holding complimentary weight loss seminars in Los Angeles ... can be accessed at their official website. oBand Surgery ... recovery time. Their highly skilled panel of surgeons and ... , A senior executive working with oBand Surgery ...
(Date:6/18/2013)... PA, June 19, 2013 Recent studies linking ... of bullying-related suicide among young people, led the ... assemble an expert panel to focus on these ... the complex relationship between youth involvement in bullying ... among youth is a significant public health problem, ...
(Date:6/18/2013)... June 18, 2013 Cheap Concert Tickets has ... the tournament which gets underway in July. Soccer fans ... CONCACAF ticket order. , The popularity and hype ... the globe.    In fact, the hype of the game triggered the ... also trickled down the veins of fans from the Caribbean. ...
(Date:6/18/2013)... The Drug Delivery Partnering Terms and ... the drug delivery partnering deals and agreements entered into ... report provides a detailed understanding and analysis of how ... majority of deals are discovery or development stage whereby ... to license the license drug delivery technology. These deals ...
Breaking Medicine News(10 mins):Health News:Newport Board Group, a National Business Advisory Firm of CEOs Cautions Buyers on 5 Questions to Ask Before Acquiring a Technology-Based Middle Market Company 2Health News:Newport Board Group, a National Business Advisory Firm of CEOs Cautions Buyers on 5 Questions to Ask Before Acquiring a Technology-Based Middle Market Company 3Health News:oBand Surgery Centers Will Hold Complimentary Weight Loss Seminars in Los Angeles in June 2Health News:Bullying and suicide among youth is a public health problem 2Health News:CONCACAF Tickets Have Been Released for Martinique, Mexico, Panama, El Salvador, Trinidad, Tobago, Haiti, Honduras, Costa Rica, Cuba, Belize, US, Canada, Honduras & Cuba 2Health News:CONCACAF Tickets Have Been Released for Martinique, Mexico, Panama, El Salvador, Trinidad, Tobago, Haiti, Honduras, Costa Rica, Cuba, Belize, US, Canada, Honduras & Cuba 3Health News:New Drug Delivery Partnering Terms and Agreements Market Study Report Available at MarketResearchReports.Biz 2Health News:New Drug Delivery Partnering Terms and Agreements Market Study Report Available at MarketResearchReports.Biz 3Health News:New Drug Delivery Partnering Terms and Agreements Market Study Report Available at MarketResearchReports.Biz 4
... police officers, school leaders, in addition to the East ... break out. // Officials belonging to these departments are ... department everywhere has to be at the forefront while ... epidemics in the past which had devastated whole civilizations. ...
... of Biological Sciences, University of Southampton have reported that ... to inhibit the growth of Influenza A virus. In ... copper reduced the Plaque Forming Units (PFU) of Influenza ... there is an increased world wide threat of bird ...
... suffer from asthmatic symptoms, carrying a girl foetus are more ... a male foetus, // according to a recent study. Michael ... studied 702 pregnant women throughout southern New England who were ... selected points in pregnancy. ,Lung function and ...
... to India for the sake of low priced cosmetic ... waistline, rhinoplasty, and breast improvements are very expensive. // ... UK every year. ,Recent figures released ... that breast enlargement topped the list of cosmetic operations ...
... Lords committee report has revealed that about 90% of ... not actually been tested on children. Drugs like thyrozine, ... to children in spite of them not being licensed ... given to children have not undergone proper tests with ...
... Researchers belonging to the Oxford University in England have revealed ... their own treatment and taught to scale down the risk ... be avoided. Those patients who change the doses of warfarin, ... blood run the risk of dying within two years, which ...
Cached Medicine News:Health News:More People Come To India For Cosmetic Surgery 2
(Date:6/18/2013)... 2013  Decision Resources, one of the world,s ... healthcare issues, announces that its Market Access Tracker ... Middle East and Africa ... and opportunities to gaining and maintaining favorable market ... countries. The countries covered by Market Access Tracker ...
(Date:6/18/2013)... -- Today, Wall Street Reports announced new research ... Health Management Associates Inc. (NYSE: HMA ), IDEXX ... (NASDAQ: ISIS ), and Trius Therapeutics Inc. (NASDAQ: ... - including full price targets, industry analysis and analyst ratings ... Research Report On June 7, 2013, Gilead Sciences ...
(Date:6/18/2013)... BASKING RIDGE, N.J. , June 18, 2013 /PRNewswire/ ... Adrian Peterson and professional family expert ... are partnering with Mylan Specialty L.P., the fully integrated ... MYL ), to raise awareness of this significant health ... of the U.S. Food and Drug Administration (FDA) approval ...
Breaking Medicine Technology:Decision Resources' Market Access Tracker Now Covers the Middle East and Africa 2Decision Resources' Market Access Tracker Now Covers the Middle East and Africa 3Industry Shows a Healthy Pulse with Priority Reviews, Positive Results, New Testing Procedures, and Partnerships - Research Report on Gilead, Health Management, IDEXX, ISIS, and Trius Therapeutics 2Industry Shows a Healthy Pulse with Priority Reviews, Positive Results, New Testing Procedures, and Partnerships - Research Report on Gilead, Health Management, IDEXX, ISIS, and Trius Therapeutics 3Industry Shows a Healthy Pulse with Priority Reviews, Positive Results, New Testing Procedures, and Partnerships - Research Report on Gilead, Health Management, IDEXX, ISIS, and Trius Therapeutics 4Industry Shows a Healthy Pulse with Priority Reviews, Positive Results, New Testing Procedures, and Partnerships - Research Report on Gilead, Health Management, IDEXX, ISIS, and Trius Therapeutics 5Industry Shows a Healthy Pulse with Priority Reviews, Positive Results, New Testing Procedures, and Partnerships - Research Report on Gilead, Health Management, IDEXX, ISIS, and Trius Therapeutics 6Mylan Specialty L.P. Joins Forces with Adrian Peterson and Jo Frost to Launch Anaphylaxis Preparedness Campaign 2Mylan Specialty L.P. Joins Forces with Adrian Peterson and Jo Frost to Launch Anaphylaxis Preparedness Campaign 3Mylan Specialty L.P. Joins Forces with Adrian Peterson and Jo Frost to Launch Anaphylaxis Preparedness Campaign 4Mylan Specialty L.P. Joins Forces with Adrian Peterson and Jo Frost to Launch Anaphylaxis Preparedness Campaign 5Mylan Specialty L.P. Joins Forces with Adrian Peterson and Jo Frost to Launch Anaphylaxis Preparedness Campaign 6Mylan Specialty L.P. Joins Forces with Adrian Peterson and Jo Frost to Launch Anaphylaxis Preparedness Campaign 7Mylan Specialty L.P. Joins Forces with Adrian Peterson and Jo Frost to Launch Anaphylaxis Preparedness Campaign 8
... /PRNewswire-Asia/ -- Golden Meditech Holdings Limited ("Golden ... - 801.HK; 910801.TW), a leading healthcare enterprise in China, ... China Holdings Limited, the Group,s associate, for US$15 million. ... FunTalk China will be reduced 19.8%.  The Group will ...
... Medical Alarm Concepts Holding, Inc. (OTCQB:MDHI), manufacturer of the ... the users to speak and listen directly through the ... corporate activities. The following comments are from Medical Alarm ... the past several months we have been relatively quiet ...
Cached Medicine Technology:Golden Meditech Disposes of 2.0% Stake in FunTalk China for US$15 Million 2Medical Alarm Concepts Investor Update - Several Initiatives in Place Designed to Significantly Accelerate Growth 2Medical Alarm Concepts Investor Update - Several Initiatives in Place Designed to Significantly Accelerate Growth 3
High intensity lamp with built-in, switchable spare lamp. Low-noise fan with reduced air turbulence....
... of two plastic parts that clamp a ... into the patient's cornea like a standard ... development since the 1960s and has gradually ... 1992. About 600 implantations have been performed. ...
PDA application providing complex evaluation and management coding rule interactive templates....
PDA-version of the complete ICD-9 diagnosis codes....
Medicine Products: