Navigation Links
Study offers clues to cause of kids' brain tumors
Date:11/16/2012

ll types helps explain why gliomas are most often found in the optic nerves and brainstem of children with NF1these areas are where the susceptible cell types reside.

With that in mind, Gutmann and his colleagues tested the effects of the unusual fusion BRAF protein in neural stem cells from the cerebellum, where sporadic pilocytic astrocytomas often form, and in cells from the cortex, where the tumors almost never develop.

"Abnormal BRAF only results in increased growth when it is placed in neural stem cells from the cerebellum, but not the cortex," Gutmann says. "We also found that putting fusion BRAF into mature glial cells from the cerebellum had no effect."

When fusion BRAF causes increased cell proliferation, postdoctoral fellows Aparna Kaul, PhD and Yi-Hsien Chen, PhD, showed that it activates the same cellular growth pathway, called mammalian target of rapamycin (mTOR), that is normally also controlled by the NF1 protein. An extensive body of research into the mTOR pathway already exists, including potential treatments to suppress its function in other forms of cancer.

"We may be able to leverage these insights and our previous work in NF1 to improve the treatment of these common pediatric brain tumors, and that's very exciting," Gutmann says.

Gutmann and his colleagues are now working to identify more of the factors that make particular brain cells vulnerable to the tumor-promoting effects of the NF1 gene mutation and fusion BRAF. They are also developing animal models of sporadic pilocytic astrocytoma for drug discovery and testing.


'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... ... In the most recent testosterone lawsuit news related to the ... Androgel testosterone attorneys report that a “Mini Status Conference” was held recently, according to ... of the status conference, which was held that day, according to court documents. While ...
(Date:7/31/2015)... ... July 31, 2015 , ... Intellitec Solutions announced today ... of Microsoft Dynamics GP for a senior living facility in Maine. Having achieved ... living communities in 16 states. This further expansion was again a factor of ...
(Date:7/30/2015)... ... ... When responsible for the care of an aging loved one, summer vacations ... What happens if mom falls? Who will remind Dad to take his medications? What ... not taking time away from caregiving responsibilities can lead to bigger problems – caregiver ...
(Date:7/30/2015)... ... 31, 2015 , ... On July 22nd the Bradenton Herald reported ... solutions for controlling the heroin outbreak. Ultimately the committee expressed lack of funding, and ... the heroin crisis in North Florida. The task force has proposed to instate counselors ...
(Date:7/30/2015)... ... July 30, 2015 , ... The Clinical Data ... are pleased to announce that data standards for clinical research in the areas ... CDISC website . These three Therapeutic Area (TA) standards were developed per ...
Breaking Medicine News(10 mins):Health News:Testosterone Lawsuit News: Androgel Lawsuit Conference Held 2Health News:Testosterone Lawsuit News: Androgel Lawsuit Conference Held 3Health News:Testosterone Lawsuit News: Androgel Lawsuit Conference Held 4Health News:Intellitec Solutions Expands Long term Care ERP Offerings to Maine 2Health News:Aging Life Care Association™ Experts Offer Tips for Caregivers in Need of Vacation Time 2Health News:Aging Life Care Association™ Experts Offer Tips for Caregivers in Need of Vacation Time 3Health News:Manatee County’s Opioid Task Force Calls for More Funding and Face to Face Counseling After Overdose 2Health News:Manatee County’s Opioid Task Force Calls for More Funding and Face to Face Counseling After Overdose 3Health News:CDISC Releases Clinical Research Data Standards for Schizophrenia, Hepatitis C and Dyslipidemia 2Health News:CDISC Releases Clinical Research Data Standards for Schizophrenia, Hepatitis C and Dyslipidemia 3Health News:CDISC Releases Clinical Research Data Standards for Schizophrenia, Hepatitis C and Dyslipidemia 4Health News:CDISC Releases Clinical Research Data Standards for Schizophrenia, Hepatitis C and Dyslipidemia 5
... Residents forced to,leave their homes and businesses due to flooding ... their belongings. The Restoration Industry,Association (RIA, formerly ASCR) suggests that ... during an evacuation:, -- Health & homeowners ... irreplaceable mementos, disposable camera, digital ...
... /PRNewswire/ - Media representatives are invited,to a photo opportunity ... Schwarzenegger, the California Governor, in light of an,international collaboration ... BIO 2008 International Convention in San Diego., ... Health ...
... 18, 2008) -- Could injecting a gene into a ... life-threatening condition? Physician-scientists are setting out to answer that ... to treat severe heart failure. , NewYork-Presbyterian Hospital/Columbia ... New York City area where the therapy is currently ...
... More Components to Fully Measure Quality, WASHINGTON, ... today commended the Centers for Medicare & Medicaid,Services ... care through,the newly introduced "five-star" rating system, but ... index, any system that relies heavily,on survey data ...
... Diagnostic Technologies in Development for Use in ... ... & Johnson Nordic,AB, a Johnson & Johnson company, today announced ... vitro diagnostic (IVD) technologies,for use in Point-of-Care (POC) and near-patient ...
... Thousands of Racers and Sponsorship of Survivor Cafe Continues Longstanding ... Community Support By Binson,s, DETROIT, ... the May 31st Susan G. Komen Detroit Race for,the Cure(R) with the ... team., For 26 years, the Komen Race for the Cure Series ...
Cached Medicine News:Health News:Restoration Industry Association Provides Evacuation Checklist for Residents Impacted by Flooding 2Health News:First gene therapy for heart failure offered at NewYork-Presbyterian/Columbia 2Health News:AHCA Emphasizes Quality Improvement in America's Nursing Homes 2Health News:Johnson & Johnson Nordic AB Acquires Amic 2Health News:Johnson & Johnson Nordic AB Acquires Amic 3Health News:Fight Against Breast Cancer Receives Big Boost During Susan G. Komen Detroit Race for the Cure(R) With 344 Participants From Binson's, Northwood 2Health News:Fight Against Breast Cancer Receives Big Boost During Susan G. Komen Detroit Race for the Cure(R) With 344 Participants From Binson's, Northwood 3Health News:Fight Against Breast Cancer Receives Big Boost During Susan G. Komen Detroit Race for the Cure(R) With 344 Participants From Binson's, Northwood 4
(Date:7/30/2015)... Takeda Pharmaceutical Company Limited ("Takeda") today announced ... post-marketing commitment and submissions of data to regulatory ... Cancer Risk Characterization Study , a large (n= ... four European countries, for pioglitazone containing medicines, including ... of follow-up. Findings demonstrate that there is no ...
(Date:7/30/2015)... -- Global ENT (Ear, Nose, And ... 23.01 million in 2022, according to a new study ... population, increasing prevalence of ear, nose, and throat related ... target customer base are expected serve this market as ... to estimates published by the WHO, 15% of adult ...
(Date:7/30/2015)... , July 30, 2015 ... market ? Which areas are going to grow at ... shows you potential revenues to 2025, assessing data, trends, ... report provides 176 tables, charts, and graphs. Discover ... future market prospects. Our new study lets you assess ...
Breaking Medicine Technology:Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 2Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 3Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 4Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 5Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 6ENT Devices Market Size to Reach $23.01 Billion by 2022: Grand View Research, Inc. 2ENT Devices Market Size to Reach $23.01 Billion by 2022: Grand View Research, Inc. 3ENT Devices Market Size to Reach $23.01 Billion by 2022: Grand View Research, Inc. 4ENT Devices Market Size to Reach $23.01 Billion by 2022: Grand View Research, Inc. 5Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 2Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 3Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 4Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 5Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 6
... INDIANAPOLIS, Sept. 7 BioStorage Technologies Inc., a ... logistics and sample management for the biotechnology and ... Hager to global director of supply chain. ... will spearhead BioStorage Technologies, supply chain activities for ...
... that a new market research report is ... The Top 10 Orthopedic Device Companies: Financial ... http://www.reportlinker.com/p0289100/The-Top-10-Orthopedic-Device-Companies-Financial-performance-research-activities-and-growth-strategies.html ... competitive and has reached maturity, as demonstrated ...
Cached Medicine Technology:BioStorage Technologies Appoints New Global Director of Supply Chain 2Reportlinker Adds The Top 10 Orthopedic Device Companies: Financial performance, research activities, and growth strategies 2Reportlinker Adds The Top 10 Orthopedic Device Companies: Financial performance, research activities, and growth strategies 3Reportlinker Adds The Top 10 Orthopedic Device Companies: Financial performance, research activities, and growth strategies 4Reportlinker Adds The Top 10 Orthopedic Device Companies: Financial performance, research activities, and growth strategies 5Reportlinker Adds The Top 10 Orthopedic Device Companies: Financial performance, research activities, and growth strategies 6Reportlinker Adds The Top 10 Orthopedic Device Companies: Financial performance, research activities, and growth strategies 7Reportlinker Adds The Top 10 Orthopedic Device Companies: Financial performance, research activities, and growth strategies 8
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: