Navigation Links
Study of tribe could help find East Asian skin color genes
Date:8/28/2012

Genetic investigation of a Malaysian tribe may tell scientists why East Asians have light skin but lower skin cancer rates than Europeans, according to a team of international researchers. Understanding the differences could lead to a better way to protect people from skin cancer.

While the genetics of skin color is largely unknown, past research using zebrafish by Penn State College of Medicine's Keith Cheng, M.D., Ph.D., identified the gene in Europeans that differs from West Africans and contributes to a lighter skin color. Mutations in the genes SLC24A5 and SLC45A2 are largely responsible for European pigmentation, showing only single amino acid differences between Europeans and West Africans. Each version of a gene is called an allele.

While East Asians -- Chinese, Japanese and Korean -- also are light skinned, these European alleles are not present, suggesting that while both groups' lighter skin color evolved to allow for better creation of vitamin D in northern climates, they did so in a different way. This difference also affects skin cancer rates. Europeans have 10 to 20 times higher rates of melanoma than Africans. However, despite also having lighter skin, East Asians have the same melanoma rates as Africans. The reason for this difference can only be explained when the gene mutations for both groups are found.

"By finding the differences, we have the potential to find ways to make people with the European ancestry genes less susceptible to skin cancer," said Cheng, professor of pathology.

This is a challenge, because to find the unidentified mutations, researchers must study a population that includes a blend of original African ancestry and East Asian ancestry, with little European contribution.

The Senoi, one of three indigenous tribes from Peninsular Malaysia, meet this condition. The Senoi are believed to include ancestry of a dark-skinned tribe called the Negrito, and a regional Mongoloid population of Indo-China, s
'/>"/>

Contact: Matthew Solovey
msolovey@hmc.psu.edu
717-531-8606
Penn State
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Chronic Cough Responds to Epilepsy Drug, Study Finds
2. Early Stenting Best for Some Heart Patients: Study
3. Midlife Fitness May Mean Healthier Old Age, Study Finds
4. Study questions technique to repair ruptured abdominal aortic aneurysms
5. Stopping Controversial Asthma Drugs Could Have Downside: Study
6. Divorced parents in hostile relationships use technology to sabotage communication, MU study finds
7. Working moms spend less time daily on kids diet, exercise, study finds
8. You Can Learn While You Sleep, Study Suggests
9. Excess Pounds Raise Risk of Breast Cancer Recurrence, Death: Study
10. Study explores injury risk in military Humvee crashes
11. Electronic Cigarettes Have Slight Impact on Heart: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2013)... New York, New York (PRWEB) May 25, 2013 ... patients who allegedly suffered serious, life-threatening episodes of internal bleeding ... federal litigation underway in U.S. District Court, Southern District of ... on the Court’s website, 818 Pradaxa side effect claims had ... 24, 2013. That’s up from 705 claims reported by ...
(Date:5/25/2013)... 25, 2013 On May 25, Voices ... research and advocacy, comments on a new study by ... incorporating cold atmospheric plasma into brain cancer treatment may ... to a Science Daily article, physicists from ... and physicians demonstrated the “synergistic effect of cold atmospheric ...
(Date:5/25/2013)... 25, 2013 Dr. Farooq Ashraf, founder ... in Dubai, has announced his practice’s adoption of The ... only FDA-cleared femtosecond laser proven with more than 10 ... precision of LASIK. , “We are happy to announce ... Laser at our Dubai LASIK practice,” Ashraf said Thursday. ...
(Date:5/25/2013)... The Slim Weight Patch has been clinically proven ... due to the highly sought after ingredients that have been ... an extra 2 months supply & premium membership of Slimming+ ... body you desire faster than ever. , Click Here ... Slim weight patch consumers can observe instant results within only ...
(Date:5/25/2013)... Texas (PRWEB) May 25, 2013 ... stressful than finals week. Increasingly, they are turning ... stay awake and study. For more on this, ... a drug treatment facility, warns that students who ... finals” are at risk for developing a physical ...
Breaking Medicine News(10 mins):Health News:Pradaxa Lawsuits Mount, as Filings in Federal Pradaxa Side Effect Litigation Exceed 800, Bernstein Liebhard LLP Reports 2Health News:Pradaxa Lawsuits Mount, as Filings in Federal Pradaxa Side Effect Litigation Exceed 800, Bernstein Liebhard LLP Reports 3Health News:Voices Against Brain Cancer Comments on Study that Shows Cold Plasma’s Success Against Brain Cancer Cells 2Health News:Atlanta Vision Clinic Acquires the Latest in Blade-Free Lasik Technology Bringing Dubai Patients the Intralase Method 2Health News:Slim Weight Patch Advanced Weight Loss System Offers Extra Two Month Supply and Membership for Maximum Weight Loss 2Health News:Addiction and Drug Abuse: Study Drug Adderall Abuse Spikes During Finals 2
... second-generation drug-eluting stentNATICK, Mass., March 3 Boston ... announced the launch of its TAXUS(R) Liberte(R) Paclitaxel-Eluting ... was approved on January 28 by the Ministry ... granted yesterday by the National Health Insurance System.TAXUS ...
... -- For some cancer patients, the soles of their feet ... others may become forgetful because of some types of chemotherapy. ... their loved one,s well-being. , Both share a need ... range of topics involving diagnosis, treatments, or unexpected symptoms. ...
... Chester Santos Trains to Defend His TitleNORTHRIDGE, Calif., March ... 99 faces and names, two decks of shuffled playing ... a matter of minutes. Chester Santos, the 2008 USA ... challenges, among others, when he defends his title at ...
... Life as Fully as Possible , ALEXANDRIA, Va., March ... wants all people to know that hospice delivers the ... caregivers who are coping with life-limiting illness. A recent ... Legal Quandary," by Greg Bluestein, 03/02/09) carries a misinformed ...
... Source of Antioxidant MelatoninLANSING, Mich., March 3 Setting ... side effect of disrupting your body,s clock. In ... sleep may affect us for days or even weeks.(i)Experts ... regulate the body,s sleep-wake cycle. Produced naturally by the ...
... asthma**, One in nine children, One in ten adults. ... tobacco smoke in their home , 402 people died due ... 65 years , People with asthma should have a written ... plans are written instructions telling patients what to do if their ...
Cached Medicine News:Health News:Boston Scientific Announces Japanese Launch of Taxus(R) Liberte(R) Drug-Eluting Stent System 2Health News:Boston Scientific Announces Japanese Launch of Taxus(R) Liberte(R) Drug-Eluting Stent System 3Health News:Walther Cancer Foundation grant funds new IU Simon Cancer Center Web site section 2Health News:The Making of a Memory Champion 2Health News:The Making of a Memory Champion 3Health News:NHPCO Comments on Misleading Quote in Associated Press Article and Provides Helpful Information 2Health News:'America's Super Fruit' May Help Reset Body Clock 2Health News:'America's Super Fruit' May Help Reset Body Clock 3
(Date:5/24/2013)... LOS ANGELES , May 24, 2013  An ... gathered on Saturday, May 18, in Santa ... findings on new lung-sparing therapies for MPM, a rare ... and commonly affects the pleura, the lining of the ... Heart, Lung and Blood Institute, the 3rd Annual International ...
(Date:5/24/2013)... 24, 2013 In accordance with Rule 17.1 and ... of the United States Exchange Act, Echo Pharma Acquisition Limited ... Elan Corporation (NYSE: ELN). Background On ... an offer for the entire of the issued and to ... "Original Offer").  On 20 May 2013, Royalty ...
(Date:5/23/2013)... 24, 2013 3SBio Inc. (NASDAQ: ... leading China -based biotechnology company ... products, announced today that, at an extraordinary general ... voted in favor of the proposal to authorize ... of merger dated February 8, 2013, among Decade ...
Breaking Medicine Technology:International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 2International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 3Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 2Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 3Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 4Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 5Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 6Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 7Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 8Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 93SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 23SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 3
... The Allen Institute for Brain Science has released the ... a previously unthinkable feat made possible through leading-edge technology ... documentation.  The unprecedented mappings are the foundation for the ... to advance the Institute,s goal to accelerate understanding of ...
... 2011 Asante Solutions, Inc. (Asante), a medical device ... the CE mark for its Pearl Insulin Pump, the ... The CE mark is a European proof of conformity ... environmental requirements. Asante has begun discussions with potential distribution ...
Cached Medicine Technology:Allen Institute for Brain Science Announces First Comprehensive Gene Map of the Human Brain 2Allen Institute for Brain Science Announces First Comprehensive Gene Map of the Human Brain 3Allen Institute for Brain Science Announces First Comprehensive Gene Map of the Human Brain 4Asante Solutions, Inc. Receives CE Mark for Pearl™ Insulin Pump 2
...
30 Pre-formed and razor sharp...
Stab incision blades color coded for simple and accurate identification...
Open wire loops decrease the chance of interfering with instruments, Designed to retract the eyelid during ophthalmic microsurgery or minor office procedures...
Medicine Products: