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Study of 'sarcoid-like' granulomatous pulmonary disease finds elevated rates in WTC responders
Date:1/6/2011

Mount Sinai researchers coordinating the largest clinical study to date of "Sarcoid Like" Granulomatous Pulmonary Disease in World Trade Center (WTC) responders have found that the rate of the condition was increased in this group as compared to the records of pre-9/11 FDNY personnel. The study is published online in the American Journal of Industrial Medicine.

The Mount Sinai researchers studied almost 20,000 responders who had an initial exam in the Mount Sinai World Trade Center Medical Monitoring and Treatment Program between July 2002 and September 2007. Overall rates of "Sarcoid Like" Granulomatous Pulmonary Disease were elevated and peaked with an incidence rate of 54 cases per 100,000 between the years 2003 and 2004. Previous studies of pre-9/11 FDNY personnel showed an average yearly rate of 15 cases per 100,000. In addition, patients with the disease had lung function abnormalities consistent with prior studies of WTC responders. Similar findings have also been reported by two other cohort studies, the Fire Department of New York City (Izbicki et al. 2007) and the World Trade Center Registry (Jordan HT et al. 2008).

"More than 50,000 men and women were exposed to products of combustion and particulate matter following the September 11th attacks," said the study's lead author Laura Crowley, MD, Assistant Professor, Preventive Medicine, Mount Sinai School of Medicine.

"Our findings support the hypothesis that environmental exposures generated by the destruction of the World Trade Center may cause 'Sarcoid Like' Granulomatous Pulmonary Disease. The screening and monitoring of all WTC responders, including periodic chest radiography and spirometry, must continue so that the population's medical issues may be optimally addressed by identifying and treating diseases in their earlier stages," she said.

Like sarcoidosis, "Sarcoid Like" Granulomatous Pulmonary Disease appears to be a multisystem disease that caus
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Contact: Mount Sinai Press Office
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212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

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