Navigation Links
Study of cancer cell metabolism yields new insights on leukemia
Date:1/17/2013

ed the pathways involved in oxidative phophorylation, with an eye toward finding an Achilles' heel to stop the process. They discovered that an important gene, BCL-2, is elevated and central to leukemia stem cell energy production.

The team also knew that drugs to inhibit BCL-2 are in various stages of development in the pharmaceutical industry; Lagadinou and Jordan found two such compounds and tested them in human leukemia specimens. Their findings showed the drugs preferentially killed inactive and metabolically slower leukemia stem cells.

Leukemia is known for its ability to lie dormant for long periods, despite treatment, but then suddenly begin another assault.

"This treatment shows promise toward a dormant leukemic stem cell subpopulation that is relatively untouched by conventional drugs," Lagadinou said. "It's also important to note that normal cells were not harmed by the compounds, because they can use alternative pathways to generate energy."

Without the toxicity to healthy cells, researchers hope they can target the disease during periods of remission, when mopping up residual leukemia is essential.

Leukemia is a blood cancer with four common types: acute myelogenous leukemia (AML), acute lymphoblastic (ALL), chronic myeloid leukemia (CML), and chronic lymphoblastic (CLL). AML is most common in adults and the most difficult to treat, in part because it affects immature cells. Nearly 50,000 new cases are diagnosed each year, with about half resulting in death.

Investigators have learned during the past decade that many therapies were not designed to kill the root of leukemia, the so called "leukemia stem cells," and therefore never truly eliminate the disease.

In fact, even the most modern cancer treatments were developed under the assumption that all cancer metabolism relies on glycolysis as a fuel source. This makes the URMC study and the discovery that oxidative phosphorylation is the single fuel source for leukemia stem
'/>"/>

Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... Reinberg HealthDay Reporter FRIDAY, ... should reassure the millions of American women who have migraine: ... "There is no association between migraine and breast cancer ... medicine at Harvard Medical School. "There is no positive association, ... no protective effect either." About 18 percent of American ...
(Date:12/15/2014)... December 15, 2014 The increase in prevalence ... of the main factors which is contributing to the growth ... the diagnosis and treatment of hearing loss and balance disorders ... three parts - microphone, speaker and amplifier. The global market ... of 6.01% during the period from 2014 to 2019. Some ...
(Date:12/15/2014)... 15, 2014 Emergo Group, Inc., a ... countries in North and South America, Europe, the Middle ... industry participants for its 2015 Medical Device Industry Survey. ... identify upcoming business and market trends as well as ... survey targets areas including:, , Overall ...
(Date:12/15/2014)... (PRWEB) December 15, 2014 At the ... organizations AutismOne and Focus Autism ... attendees with research on the effects of toxins to ... and intervention information. , Luminaries such as Dr. ... from abroad with esteemed, credentialed colleagues of the United ...
(Date:12/15/2014)... Kenmode Precision Metal Stamping has announced that Abid ... Assurance. He brings more than 15 years of ... manufacturers in the U.S. and abroad. , He ... Sonoco Products Company in the Protective Solutions Division, Vice ... Manager for Prince Industries, all in the Chicago area. ...
Breaking Medicine News(10 mins):Health News: No Link Between Migraine, Breast Cancer Risk, Study Says 2Health News:Audiological Devices Market 2019 Demand for Esthetic Hearing Aids Drives the Growth, Says a Report at ReportsnReports.com 2Health News:Audiological Devices Market 2019 Demand for Esthetic Hearing Aids Drives the Growth, Says a Report at ReportsnReports.com 3Health News:Audiological Devices Market 2019 Demand for Esthetic Hearing Aids Drives the Growth, Says a Report at ReportsnReports.com 4Health News:Emergo’s Annual Survey Assessing the State of the Medical Device Industry Now Open 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3Health News:Kenmode Precision Metal Stamping Appoints Abid Rashid as Director of Quality Assurance 2
... CVS Caremark (NYSE: CVS ) announced ... again been recognized for customer satisfaction excellence by ... This is the third time that the Company ... center operations as providing "An Outstanding Customer Service ...
... CYBX ) today announced that the company will ... 2009 of its fiscal year ending April 24, 2009 on ... company will conduct a conference call to discuss those results ... Fiscal Year 2009 Third Quarter Results Conference Call Instructions ...
... Workouts counter functional decline, could ward off osteoarthritis, ... News) -- Exercise may play a key role ... and knee osteoarthritis (OA), two new studies show. ... following a six-week progressive strengthening program showed much ...
... cause of death with over 6 million new cases worldwide ... of cancer are diagnosed annually, and half a million Americans ... years of research, GlycoMeds ( http://www.cancer-test-kits.com ) has released the ... a way to detect it in the early stages when ...
... investigation into the shooting death of American video-journalist Brad Will has ... the discovery that one of the bullets was a ricochet. ... ... Physicians for Human Rights (PHR) charges that Mexico,s investigation into ...
... Through 2017 for Relapsing-Remitting Multiple Sclerosis, According to ... 4 Decision Resources, one of the world,s ... healthcare issues, finds that an oral disease-modifying therapy ... percent patient share in Europe and a 40 ...
Cached Medicine News:Health News:Caremark Customer Care Centers Recognized for Customer Satisfaction Excellence by J.D. Power and Associates Certified Call Center Program(SM) 2Health News:Cyberonics Announces Conference Call to Discuss Fiscal Year 2009 Third Quarter Financial Results 2Health News:Exercise Key Player in Knee Replacement Recovery 2Health News:GlycoMeds Discovery Yields Early Warning Test for Cancer 2Health News:Mexico Presents Flawed Theory in Shooting Death of American Journalist 2Health News:Mexico Presents Flawed Theory in Shooting Death of American Journalist 3Health News:Mexico Presents Flawed Theory in Shooting Death of American Journalist 4Health News:An Oral Disease-Modifying Drug for Relapsing-Remitting Multiple Sclerosis Would Earn High Patient Shares in Both Europe and the United States 2Health News:An Oral Disease-Modifying Drug for Relapsing-Remitting Multiple Sclerosis Would Earn High Patient Shares in Both Europe and the United States 3
(Date:12/17/2014)... SCOTTSDALE, Ariz. , Dec. 17, 2014 /PRNewswire/ ... of state-of-the-art interactive music products, today announced that ... Ltd, a leading manufacturer and supplier of innovative ... As part of the agreement, RSL ... Facility bundled solution specifically configured for use within ...
(Date:12/17/2014)... KENNESAW, Ga. and RALEIGH, ... Clinical Trial Marketing Communications, LLC (CTMC), and Integrated ... in patient recruitment and retention for clinical trials ... called Integrated Clinical Trial Marketing Services (i-CTMS). i-CTMS ... and retention services to pharmaceutical, biotechnology and medical ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... the "Inferior Vena Cava (IVC) Filters - Global ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... projected to reach US$435 million by 2016. The ... (2015) of the global value while Europe ...
Breaking Medicine Technology:Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 2Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 3Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 3Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 2Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 3Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 4