Navigation Links
Study of anti-CD20 therapy effective B cell depletion
Date:6/2/2008

B cells, precursors of autoantibody-secreting cells, have emerged as promising new therapeutic targets in autoimmune diseases, including rheumatoid arthritis (RA). In particular, B cell depletion with the anti-CD20 antibody rituximab seems to work for RA patients resistant to standard disease-modifying antirheumatic drugs (DMARDs) and tumor necrosis factor α (TNFα) blockers. In large trials, about half of these hard-to-treat patients respond to rituximab, achieving at least a 20 percent improvement in disease activity based on the American College of Rheumatology criteria. However, in the majority of responders, the disease relapses over time. After a single treatment with rituximab, complete remission of RA symptoms for longer than a year is very rare.

With the goal of identifying reliable predictors of response or relapse to rituximab, a trio of researchers in Germany focused on the recovery response of different B cell subsets to repeated B cell depletion. Their analysis, featured in the June 2008 issue of Arthritis & Rheumatism (www.interscience.wiley.com/journal/arthritis), reveals the critical role of memory B cells in the compromised immune reaction of RA and the short-term gains of rituximab therapy.

Conducted by Petra Roll, M.D., and Hans-Peter Tony, M.D., at the University of Wrzburg and Thomas Drner, M.D., an affiliate of the University of Berlin, the B cell investigation began with an open-label trial of one cycle of rituximab on 17 RA patients. The participants, 14 women and 3 men, had a median age of 51 years, a median disease duration of 14 years, and a history of failure to respond to DMARD and/or anti-TNFα therapy. 16 of the patients received 2 infusions rituximab, 1,000 milligrams each, 2 weeks apart, and one patient received 4 weekly infusions of rituximab at a dose of 375 mill
'/>"/>

Contact: Sean Wagner
swagner@wiley.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Large Study Identifies Most Costly Adverse Events in Childrens Hospitals
2. Large study identifies most costly adverse events in childrens hospitals
3. First study to examine vitamin D insufficiency in pediatric patients with low bone density
4. Study examines cold medication use in young children
5. Look before you leap: New study examines self-control
6. International Diabetes Federation grant supports study to prevent type 2 diabetes in India
7. Study suggests chemotherapy diminishes fertility in breast cancer patients
8. Quality of life predicts cancer survival, U-M study finds
9. USC study finds sex, age and ethnicity assciated with colorectal cancer survival
10. Montana Center for Work Physiology and Exercise Metabolism presents firefighter health study
11. Moonview Sanctuary Releases First Case Study of Client Treated Using Unique Moonview Model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... (PRWEB) July 14, 2014 The governments ... investment in the Global Mobile Health Solutions market. For ... the Health IT for Economic and Clinical Health Act ... 2009. , Analysts forecast the Global Mobile Health ... 34.88 percent over the period 2013-2018. According to the ...
(Date:7/14/2014)... SingaporeA*STAR,s Bioprocessing Technology Institute (BTI) has entered into ... pharmaceutical company, Roche, to identify novel drug candidates ... partnership brings together BTI,s capabilities in novel antibody ... (mAbs) therapeutics, opening up the possibility of ... death worldwide. , The collaboration makes use ...
(Date:7/14/2014)... The Encino cosmetic dentist ... Lumineers and porcelain veneers. These restorations are an ... preparation and greater loss of healthy tooth tissue. They ... visible flaws on the tooth. Encino dentist Dr. Mastour ... to ensure they offer the most appropriate treatment recommendations ...
(Date:7/14/2014)... Stress can slow a woman,s metabolism and lead to weight ... average age 53, who were asked about their stress levels ... 930 calories and 60 grams of fat. The Ohio State ... burn off those calories and fat. On average, women ... 24 hours burned 104 fewer calories in the seven hours ...
(Date:7/14/2014)... July 14, 2014 KeyPoint Credit Union ... 6th Annual 5K run and one-mile family fun walk. ... the park attractions, and finishes inside Levi’s® Stadium. , ... over $150,000 for the Mission City Community Fund. All ... County. , Seasoned athletes, part-time pavement-pounders and walkers ...
Breaking Medicine News(10 mins):Health News:Mobile Health Solutions Market to Grow at 34.88% CAGR by 2018, Says a New Research Report at Sandlerresearch.org 2Health News:Mobile Health Solutions Market to Grow at 34.88% CAGR by 2018, Says a New Research Report at Sandlerresearch.org 3Health News:Mobile Health Solutions Market to Grow at 34.88% CAGR by 2018, Says a New Research Report at Sandlerresearch.org 4Health News:A*STAR partners Roche to develop new cancer therapeutics 2Health News:Encino Esthetic Dental Group is Now Offering Lumineers and Porcelain Veneers 2Health News:Stress May Leave You Heading to the Cookie Jar 2
... a Northwestern University research team to discover a new class ... food and medical technologies. And the compounds are edible. ... (MOFs) that are simple to make. Most other MOFs are ... pop into your mouth and eat, and the researchers have. ...
... Stem cells might be thought of as trunks in ... they can turn into a dazzling variety other cellskidney, brain, ... has the capacity to turn into virtually any cell type ... development of cell therapies, the conquering of age-old diseases or ...
... 2 September, 2010 - Elsevier announced today the publication ... and Andropause Society (EMAS) in the journal Maturitas ... the post-reproductive health of women. The statements cover ... obesity, epilepsy, endometriosis and premature ovarian failure. Each ...
... September cover story of the nation,s leading cancer journal, ... Institute, University of Minnesota, that links capsaicin, a component ... mechanisms of the cancer-promoting effects of capsaicin are not ... a definite connection to formation of skin cancer through ...
... Nurses have a responsibility to respect and support patients who ... law and follow professional guidance at all times, according to ... Journal of Clinical Nursing . Dr Anita ... papers, together with professional and Government guidance documents, official reports ...
... Insomnia and other sleep disorders are very common, yet ... health care professionals. Now the British Association for Psychopharmacology ... of Psychopharmacology , published by SAGE, to guide psychiatrists ... BAP members, representative clinicians with a strong interest in ...
Cached Medicine News:Health News:Edible nanostructures 2Health News:Edible nanostructures 3Health News:Study finds that cancer-causing gene crucial in stem cell development 2Health News:Study finds that cancer-causing gene crucial in stem cell development 3Health News:EMAS publishes position statements about the post-reproductive health of women 2Health News:Medicinal cannabis review highlights dilemmas facing health care professionals 2Health News:Medicinal cannabis review highlights dilemmas facing health care professionals 3Health News:New guidelines to ease sleepless nights 2Health News:New guidelines to ease sleepless nights 3
(Date:7/14/2014)... July 14, 2014 CVS/pharmacy ® ... PLATINUM, a premium brand of 100% preservative-free vitamins ... growing family of exclusive CVS/pharmacy store brand products. ... with various benefits, including popular options such as ... women. The radiance PLATINUM line also has more premium options ...
(Date:7/14/2014)... , July 14, 2014 The legalization of ... – as well as a new economic driver – ... to sort out the right response to the will ... intoxicant. At a National Press Club ... a.m., two leading experts in the area of marijuana ...
(Date:7/14/2014)... N.Y. , July 14, 2014 We ... Surgery Center ("OACM") and the Ellicott City Ambulatory Surgery ... of Ellicott City Maryland . ... between Merritt Healthcare and 14 leading Orthopaedics, Sports Medicine, ... Facility will also accommodate the specialties of general surgery ...
Breaking Medicine Technology:CVS/pharmacy Launches Exclusive radiance PLATINUM Line of Preservative-Free Vitamins and Supplements 2CVS/pharmacy Launches Exclusive radiance PLATINUM Line of Preservative-Free Vitamins and Supplements 3NPC Newsmaker Program: Interpreting smoke signals from the marijuana skirmish line 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: