Navigation Links
Study links vitamin D to lung cancer survival
Date:3/1/2011

ANN ARBOR, Mich. Recent research suggests vitamin D may be able to stop or prevent cancer. Now, a new study finds an enzyme that plays a role in metabolizing vitamin D can predict lung cancer survival.

The study, from researchers at the University of Michigan Comprehensive Cancer Center, suggests that this enzyme stops the anti-cancer effects of vitamin D.

Levels of the enzyme, called CYP24A1, were elevated as much as 50 times in lung adenocarcinoma compared with normal lung tissue. The higher the level of CYP24A1, the more likely tumors were to be aggressive. About a third of lung cancer patients had high levels of the enzyme. After five years, those patients had nearly half the survival rate as patients with low levels of the enzyme.

Researchers then linked this to how CYP24A1 interacts with calcitriol, the active form of vitamin D. CYP24A1 breaks down calcitriol, which has a normal and crucial role when kept in check. But when levels of CYP24A1 climb, the enzyme begins to hinder the positive anti-cancer effects of vitamin D.

Results of the study appear in Clinical Cancer Research.

Previous studies have linked low levels of vitamin D to a higher incidence of cancer and worse survival. Researchers are looking at using vitamin D to help prevent lung cancer from returning and spreading after surgery. This new study suggests the possibility of using CYP24A1 levels to personalize this approach to those likely to benefit most.

"Half of lung cancers will recur after surgery, so it's important to find a way to prevent or delay this recurrence. A natural compound like vitamin D is attractive because it has few side effects, but it's even better if we can determine exactly who would benefit from receiving vitamin D," says study author Nithya Ramnath, M.D., associate professor of internal medicine at the U-M Medical School.

Researchers also are working to identify drugs that block CYP24A1. Block
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Global ISU study: Invasive species widespread, but not more than at home range
2. Sugary Drinks Might Raise Hypertension Risk: Study
3. Hospital use of virtual colonoscopy is on the rise, study suggests
4. For Severe Sinusitis, Oral Steroids an Option, Study Says
5. Stress May Help Spur Weight Gain in New Moms, Study Finds
6. Study finds close linkage between a rare, deadly lung condition and blood cell abnormalities
7. U. of Colorado study shows acupressure effective in helping to treat traumatic brain injury
8. Study finds breast cancer incidence rates no longer declining in US women
9. BUSM study shows chemoradiotherapy prior to surgery improves survival
10. Study comparing tenofovir gel and oral tablet finds gel provides more drug to tissue
11. Foster parents receive more support than kinship caregivers, UT Southwestern study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... -- If you make exercise fun, you,ll eat less after ... adults were led on a 1.4-mile walk and were either ... walk. The participants were given lunch after the walk, and ... 35 percent more chocolate pudding for dessert than those who ... experiment, 46 adults were given mid-afternoon snacks after their walk. ...
(Date:7/12/2014)... my mom’s stroke, she loss the use of her right side. ... his left side. Eating became a difficult task for them so ... enjoy eating again,” said an inventor, from Fayetteville, N.C. As a ... (P C H PLATE). , The PATRICIA CAROL HALL PLATE (P ... individuals who suffer from stroke, experience tremors or loss of movement. ...
(Date:7/12/2014)... For those who are unfamiliar with enzymes, ... the nutrients in food. The enzymes literally break up the ... to be absorbed by human bodies. According Dr. Henry Balzani, ... in regular food is the cause of many gastrointestinal health ... by Michelle DelPresto, a mother of 3 who is passionate ...
(Date:7/12/2014)... As reported in this July 1st article by ... June 25th, 2014 Supreme Court ruling in Riley v California ... was also met with both cheers and jeers when the ... from an individual privacy perspective, or a law enforcement perspective, ... precedent which will require law enforcement officials to obtain a ...
(Date:7/12/2014)... July 12, 2014 Praeclarus Press ... Simple as a valuable new resource for women in ... of American women work away from their children. Today’s ... the benefits of breastfeeding, but often feel unsupported when ... their babies. With its evidence-based insights, and written by ...
Breaking Medicine News(10 mins):Health News:Make Exercise Fun, Eat Less Afterwards 2Health News:New Super Digestive Enzyme, DZ10, Supercharges The Digestion Process 2Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 2Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 3Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 4Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 5Health News:Praeclarus Press Announces the Release of Working and Breastfeeding Made Simple by Nancy Mohrbacher, A Much Needed Resource For Today's Working Mothers 2
... trend in the kids, even those between the ages of 8 ... behavioral changes which marks the teenage years , seems to be ... so the sobriquet ‘tweens’, seems to fit the bill. , ... items like cell phones and iPods. The genre of music they ...
... a survey was conducted in Australia to study the attitudes ... number of Australians are concerned about the// outcome of storage ... the University of Sydney found that ,most people were wary ... that these tissues could possibly be used to produce human ...
... New research uses an electroencephalogram (EEG) to look for ... differences in emotionality and alcoholism.// The results of the ... Alcoholism: Clinical & Experimental Research. ,Research findings ... right frontal areas of the brain. The pattern of ...
... in India, Jai Prakash Narayan Apex Trauma Center (JPNATC), which ... for// treating patients of road accidents. ,The ... over 20,600 sq meters, seven-storey hospital with 200 beds, including ... starts its dry run on Monday by shifting 55 'not ...
... Foods Inc. has recalled their turkeys and ham products ... 47,000 pounds of their// products. It happened only ... meat might be tampered with the bacteria Listeria monocytogenes ... systems. ,The company added that it ...
... Conroy conducted a new study about alcoholism and published ... & Experimental Research.// The study highlighted 3 main ... asleep, but leads to poor-quality sleep later in the ... sleep can lead to alcoholism. ,· Inaccurate sleep ...
Cached Medicine News:Health News:Banking (T)issues : cloning issue surfaces 2Health News:A New Research Explores Connection Between Emotionality And Alcoholism 2Health News:A New Research Explores Connection Between Emotionality And Alcoholism 3Health News:Alcohol Dependence For Sleep Perceptions May Result In Alcoholism 2Health News:Alcohol Dependence For Sleep Perceptions May Result In Alcoholism 3
(Date:7/11/2014)... , July 11, 2014  Australian drug delivery ... that it has raised A$19.3 million via a placement ... Europe , the U.S., Asia ... million from a share purchase plan (SPP) to be ... will be made in two tranches. "This ...
(Date:7/11/2014)... ST. LOUIS , July 11, 2014 ... medical device company, announced today the positive, ... of its innovative SPiNPerc™ procedure. The SPiNPerc ... use of a percutaneous approach to biopsy ... possible.  Hospitals, patients and physicians experience positive ...
(Date:7/10/2014)... NEWPORT NEWS, Virginia , 11. ... führender Hersteller von Kameras für die ... Brust (MBI/BSGI), hat heute die CE-Zulassung ... Mit dem CE-Zeichen kann Dilon das ... seinen Vertriebsbereich auf den Großteil der ...
Breaking Medicine Technology:Phosphagenics' A$19.3 million Capital Raising 2Phosphagenics' A$19.3 million Capital Raising 3Veran Medical Publishes Lung Cancer Patient Management Study 2Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2
... 19, 2012, at 8:30 a.m. Eastern/2:30 p.m. Central European/5:30 ... and MTA: CTIC) management team will host a conference ... Thursday, April 19 8:30 a.m. Eastern/2:30 p.m. Central ... (International) Call-back numbers for post-listening available at ...
... and TRENTON, N.J., April 18, 2012 Kimberly-Clark Professional*, ... and laboratories, and TerraCycle, a leading recycler, today announced ... laboratory garment recycling initiative to include a pilot program ... program,s first six months. Since the program,s ...
Cached Medicine Technology:Kimberly-Clark Professional* and TerraCycle Expand Industry's First Cleanroom and Laboratory Garment Recycling Initiative to Include Pilot Program for Gloves 2Kimberly-Clark Professional* and TerraCycle Expand Industry's First Cleanroom and Laboratory Garment Recycling Initiative to Include Pilot Program for Gloves 3Kimberly-Clark Professional* and TerraCycle Expand Industry's First Cleanroom and Laboratory Garment Recycling Initiative to Include Pilot Program for Gloves 4
The Contoured Wrist/Forearm Support provides comfort for post-surgical immobilization, post-fracture casting, and wrist sprains and strains....
Provides wrist stability with moderate motion restriction, making it ideal for the workplace...
Provides secure fracture immobilization while allowing for full range of motion at elbow and wrist...
... Bird and Cronin, ... manufacturer of Patient Footwear, ... Patient Care Products. Our ... highest quality and available ...
Medicine Products: