Navigation Links
Study links vitamin D to colon cancer survival
Date:6/18/2008

BOSTON--Patients diagnosed with colon cancer who had abundant vitamin D in their blood were less likely to die during a follow-up period than those who were deficient in the vitamin, according to a new study by scientists at Dana-Farber Cancer Institute.

The findings of the study -- the first to examine the effect of vitamin D among colorectal cancer patients -- merit further research, but it is too early to recommend supplements as a part of treatment, say the investigators from Dana-Farber and the Harvard School of Public Health.

In a report in the June 20 issue of the Journal of Clinical Oncology, the authors note that previous research has shown that higher levels of vitamin D reduce the risk of developing colon and rectal cancer by about 50 percent, but the effect on outcomes wasn't known. To examine this question, the investigators, led by Kimmie Ng, MD, MPH, and Charles Fuchs, MD, MPH, of Dana-Farber, analyzed data from two long-running epidemiologic studies whose participants gave blood samples and whose health has been monitored for many years.

They identified 304 participants in the Nurses' Health Study and the Health Professionals Followup Study who were diagnosed with colorectal cancer between 1991 and 2002. All had had vitamin D levels measured in blood samples given at least two year prior to their diagnosis. Each patient's vitamin D measurement was ranked by "quartiles" -- the top 25 percent, the next lowest 25 percent, and so on. Those whose levels were in the lowest quartile were considered deficient in vitamin D.

The researchers followed the 304 patients until they died or until 2005, whichever occurred first. During that period, 123 patients died, with 96 of them dying from colon or rectal cancer. The researchers then looked for associations between the patients' previously measured vitamin D blood levels and whether they had died or survived.

The results showed that individuals with the vitamin D levels in the highest quartile were 48 percent less likely to die (from any cause, including colon cancer) than those with the lowest vitamin D measurements. The odds of dying from colon cancer specifically were 39 percent lower, the scientists found.

"Our data suggest that higher prediagnosis plasma levels of [vitamin D] after a diagnosis of colorectal cancer may significantly improve overall survival," the authors wrote. "Future trials should examine the role of vitamin D supplementation in patients with colorectal cancer."

The measurements of vitamin D in the patients' blood reflected both the amounts made by the body when exposed to sunlight and to all sources of the vitamin in their diets, said Ng. However, she added, there may be additional unknown factors that might account for individual differences. Patients with the highest vitamin D levels tended to have lower body-mass index (BMI) indicating that they were leaner, and also were more physically active. However, after controlling for BMI and physical activity, as well as other prognostic factors, higher vitamin D levels were still independently associated with better survival rates.

Ng said that a trial is being planned in which colon cancer patients will take vitamin D along with post-surgery chemotherapy to look for any benefits of the supplements.

Meanwhile, she said that individuals with colon cancer should consult their physicians as to whether they should add vitamin supplements to their daily regimen. Standard recommended daily amounts of vitamin D supplements range from 200 International Units (IU) per day for people under age 50 to 400 IU for people between 50 and 70, and 600 IU for those over 70.


'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

Related medicine news :

1. Study: Medicare Competitive Bidding Program Could Impede Seniors Access to Diabetes Testing Supplies
2. Study finds Childrens Hospital patient safety program improves caregiver/family communications
3. Study Shows Mothers Who Take Chlorella Boost Babies Antibodies During Breast Feeding
4. Sprinters closest to starter pistol have advantage over those farther away, says study
5. Study indicates grape seed extract may reduce cognitive decline associated with Alzheimers disease
6. Study Ties Herpes Virus to Emerging Form of Diabetes
7. Study underway to find an alternative cure for Crohns disease and ulcerative colitis
8. New study shows American Cancer Society program helps employers
9. New study shows potential to treat or prevent viral cancers
10. Harvard Study in Joint Commission Journal: Mortality Rates Lower in Leapfrog Hospitals
11. Emory study of syphilis bacteria yields valuable diagnostic tool
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Dickinson Insurance and Financial Services, ... preparation services, is providing an update on a charitable event that began earlier ... is a locally recognized nonprofit that provides shelter and care for animals seeking ...
(Date:10/13/2017)... ... 2017 , ... The International Association of Eating Disorders Professionals ... the field of eating disorders, announces the opening of early registration for the ... at the Omni Resort at ChampionsGate. , The annual iaedp™ Symposium ...
(Date:10/13/2017)... ... , ... Apple Rehab Shelton Lakes , which specializes in the delivery ... as part of a disaster drill on October 3rd. , Apple Rehab participated with ... Manager, as well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Global Healthcare ... scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare ... activity. The fun run is geared towards children of all ages; it is ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the ... save lost souls in the Philippines. “The Journey: From the Mountains to the Mission ... of the Bible. She has taught all ages and currently teaches a class of ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 West ... in innovative solutions for injectable drug administration, today announced ... the market opens on Thursday, October 26, 2017, and ... results and business expectations at 9:00 a.m. Eastern Time. ... or 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/11/2017)... , Oct. 11, 2017  True Health, ... has amplified its effort during National Breast Cancer ... hereditary cancer risks. ... Clinical Oncology calculated that more than 10 million ... inherited mutations in BRCA1 or BRCA2 and have not ...
(Date:10/10/2017)... 2017   West Pharmaceutical Services, Inc. (NYSE: ... drug administration, today shared the results of a study ... the intradermal administration of polio vaccines. The study results ... May 2017 by Dr. Ondrej Mach , Clinical ... Organization (WHO), and recently published in the journal ...
Breaking Medicine Technology: