Navigation Links
Study links long-term use of osteoporosis drugs to unusual fractures
Date:2/22/2011

TORONTO, Ont., Feb, 23, 2011Women who take commonly prescribed drugs for osteoporosis known as bisphosphonates for five years or more may be at higher risk of certain kinds of fractures of their thigh bone, a new study has found.

However, the drugs do prevent hip fractures. And, since the overall risk of thigh bone fractures caused by the drugs is low, women at high risk for hip and other osteoporosis-related fractures should not stop taking bisphosphonates, according to researchers at St. Michael's Hospital and the Institute for Clinical Evaluative Sciences.

The study was published today in the Journal of the American Medical Association (JAMA).

Typical hip fractures caused by osteoporosis occur in the upper part of the femur close to the hip joint and are an important cause of disability, need for long-term care and even death in the elderly. The risk of these kinds of fractures is reduced by bisphosphonate treatment, which was confirmed by this study.

But the study found that less common fractures lower down from the hip and closer to the middle of the femur sometimes called "atypical" or "unusual" fractures -- occurred more than 2.5 times as often in women who had taken bisphosphonates for more than five years than short-term users of the drug..

"Prolonged use of bisphosphonates is associated with rare and unusual fractures of the femur," said the lead author, Laura Park-Wyllie, a pharmaceutical safety and outcomes researcher at St. Michael's. "But the proven benefit of these drugs for the much more common fractures of osteoporosis usually outweighs the harm, especially in the initial years of treatment for osteoporosis. Women with osteoporosis, at high risk for osteoporotic fractures, should not stop taking bisphosphonate therapy because of the small risk of these thigh fractures."

Park-Wyllie said the study was prompted by an increasing number of reports of thigh bone fractures among older women who have taken the drugs sold as Fosamax, Actonel or Didrocal for five years or more and by conflicting findings from small, observational studies.

The St. Michael's-ICES study is the largest assessment of the issue to date. The researchers identified 205,466 women over age 68 who had been prescribed bisphosphonates between 2002 and 2008.

Of those, 716 women (0.35 per cent) had a fracture of the femur. These women were compared to other women of similar ages who had also been prescribed the drugs but who did not have femur fractures.

"Our study estimated that the risk of fractures to the femur was 0.13 per cent for women entering their sixth year on the drug or just over one in 1,000," Park-Wyllie said. "Use of bisphosphonates for less than five years was not associated with a significant risk of thigh fractures."

About 50 per cent of women over 50 will suffer an osteoporosis-related fracture. The most common involve the wrist and the spine, but hip fractures can have some of the most severe consequences, with one in five of those women expected to die within 12 months.


'/>"/>

Contact: Leslie Shepherd
shepherdl@smh.ca
416-864-6094
St. Michael's Hospital
Source:Eurekalert

Related medicine news :

1. Study suggests gender does not play a role in risk of death from heart attack
2. Plastics Chemical Affects U.S. More Than Canada: Study
3. USDA study confirms links between longer ragweed season and climate change
4. High Triglyceride Levels Linked to Increased Stroke Risk: Study
5. Study: For a better workday, smile like you mean it
6. National anti-drug campaign succeeds in lowering marijuana use, study suggests
7. Hearing Loss Common Among Middle-Aged Adults: Study
8. Gastric Bypass Best for Weight Loss, Study Finds
9. Climate Change Extending Ragweed Season in Colder Climes: Study
10. Study Finds Too Many Surgical Breast Biopsies Performed
11. Weight loss improves knee pain from common arthritic condition, study says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... On Dec. ... the Hard Rock Hotel San Diego honoring the 2016 MPN Heroes—eight individuals who have ... (MPNs) by going above and beyond the standard of care, demonstrating leadership within the ...
(Date:12/2/2016)... ... ... Advanced Inc., a leading provider of travel therapy and travel nursing across ... Advanced Inc.’s Chief Financial Officer, effective December 1, 2016. Jason previously served as Vice ... leadership experience to Advanced Inc. He began his career in finance at Ernst & ...
(Date:12/2/2016)... Raleigh, NC (PRWEB) , ... December 02, 2016 , ... ... the Open Enrollment Period (or Annual Election Period), is ending December 7th. Currently-enrolled Medicare ... plan (Part C) or prescription drug plan (Part D) need to make changes during ...
(Date:12/2/2016)... , ... December 02, 2016 , ... ... interview of two ostomy patients, standing as living proof that attitude and determination ... digestive diseases and issues that spike around the holidays. This campaign will offer ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... Health" in USA Today, which covers the innovative treatments, therapeutic technologies, and revolutionized ... fulfilling lives. “We are prolonging life 6 years in the last 3 decades,” ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2016 According to a ... by Product (Instruments, Reagents, Software), Technology (Immunoassay, Clinical ... Nephrology, Infectious Diseases) - Forecast to 2021" published ... USD 60.22 Billion in 2016. This market is ... during the forecast period (2016-2021) to reach USD ...
(Date:12/2/2016)...  The Addiction Treatment Advisory Group (ATAG), created ... Pharmacy (AMCP), has released detailed findings on how ... addiction crisis, including through improved access to naloxone ... newly released paper, "The Role of Managed Care ... issues around gaps and barriers to addiction treatment ...
(Date:12/2/2016)... -- Boston Scientific Corporation (NYSE: BSX ) ... assets and capabilities of the Neovasc, Inc., (NASDAQ: ... as well as a 15% equity stake in Neovasc, ... Neovasc advanced biological tissue business makes elements used in ... System. * Upon completion of the transaction, the ...
Breaking Medicine Technology: