Navigation Links
Study links gastric bypass surgery to increased risk of kidney stones
Date:6/26/2008

CHICAGO (June 26, 2008) Morbidly obese patients who undergo a particular type of gastric bypass surgery called Roux-en-Y gastric bypass (RYGB) are at an increased risk of developing kidney stones small, pebble-like deposits that can result in severe pain and require an operation to remove them earlier than previously thought. These stones develop in patients within only a few months following the procedure rather than several months to years, according to research published in the June issue of the Journal of the American College of Surgeons.

"Our data suggests that RYGB is associated with an increased risk of forming kidney stones as early as three months post-operation," according to the study's lead investigator, Manoj Monga, MD, FACS, Professor of Urologic Surgery, University of Minnesota, Minneapolis. "We hope our findings and subsequent research will eventually allow clinicians to more accurately counsel patients on their individual risk of kidney stones and develop strategies for the prevention of this sometimes painful condition, such as dietary modification and medical therapy."

RYGB is the most commonly performed surgical intervention for morbid obesity. During the procedure, a small pouch is created by stapling part of the stomach together or by banding the stomach, limiting the amount of food a patient can eat. Next, a Y-shaped section of the small intestine is attached to the pouch to allow food to bypass the first part of the intestines. This process causes reduced calorie and nutrient absorption. Although RYGB is a safe and effective treatment for morbid obesity, nephrolithiasis (the formation of kidney stones) has recently raised concerns among patients undergoing RYGB.

"Although this study demonstrates that there is a higher risk for developing kidney stones, it is important to weigh the risk against the many benefits that RYGB has for the morbidly obese patient, including decreasing cardiac morbidity and improving diabetes," Dr. Monga added.

Surgeons conducted a prospective, longitudinal study of 24 morbidly obese adults (9 men and 15 women) from a university-based bariatric surgery clinic scheduled to undergo RYGB between December 2005 and April 2007. Five patients had a history of nephrolithiasis. Patients provided 24-hour urine collections for analysis seven days before and 90 days after operation. The primary endpoints were change in the amount of the compound oxalate in the urine and the relative supersaturation of calcium oxalate (that is, whether the urine contained more calcium oxalate than could normally be dissolved, potentially leading to crystallization) from baseline to three months post-RYGB. Both of these factors have been demonstrated by earlier studies to be major risk factors for the development of kidney stones.

Significant increases were noted in urinary oxalate excretion (31 10 mg/d versus 41 18 mg/d; p=0.026) and relative supersaturation of calcium oxalate (1.73 0.81 versus 3.47 2.59; p=0.030) at only three months post-RYGB. Six patients (25%) developed de novo hyperoxaluria, with oxalate excretion increasing from 26 12 mg/d to 63 12 mg/d (p =0.0046) There were no preoperative patient characteristics predictive of increased risk of kidney stone formation.

The reason for increased likelihood of the development of kidney stones following this type of gastric bypass surgery is not entirely understood. A possibility is that the anatomic rearrangement caused by the operation establishes a mildly malabsorptive state, which may be responsible for the increase in the excretion of urinary electrolytes. Kidney stones could also result from an alteration in the gut microflora (normal bacteria) caused by the procedure.


'/>"/>

Contact: Sally Garneski
pressinquiry@facs.org
312-202-5409
Weber Shandwick Worldwide
Source:Eurekalert

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to ... unique items from across the nation, this holiday-themed event will raise funds and awareness ... VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... one of the most popular and least understood books in the Holy Scriptures, Revelation. ... descriptions that have baffled scholars for centuries. Many have tossed it off as mere ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the ... save lost souls in the Philippines. “The Journey: From the Mountains to the Mission ... of the Bible. She has taught all ages and currently teaches a class of ...
(Date:10/12/2017)... San Francisco, CA (PRWEB) , ... October 12, ... ... and Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus ... sleep apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical ... innovative solutions for injectable drug administration, today shared the ... ID Adapter for improving the intradermal administration of polio ... Skin Vaccination Summit in May 2017 by Dr. ... Polio Department, World Health Organization (WHO), and recently published ...
(Date:10/4/2017)... 2017 OBP Medical , a ... devices, today announced regulatory approval from ... Agência Nacional de Vigilância Sanitária (ANVISA)) to market ... retractor with integrated LED light source and smoke ... exposure of a tissue pocket or cavity during ...
(Date:10/2/2017)... 2, 2017 The Rebound mobile app is poised ... reverse the tide of prescription drug addiction. The app empowers ... intake and stepping down their dosage in a safe, controlled ... December 2017; the first 100,000 people to sign up will ... http://www.rebound-solution.com/ ...
Breaking Medicine Technology: