Navigation Links
Study links cardiac hormone-related inflammatory pathway with tumor growth
Date:6/28/2013

Tampa, FL (June 28, 2013) -- A cardiac hormone signaling receptor abundantly expressed both in inflamed tissues and cancers appears to recruit stem cells that form the blood vessels needed to feed tumor growth, reports a new study by scientists at the University of South Florida Nanomedicine Research Center.

The research may lead to the development of new drugs or delivery systems to treat cancer by blocking this receptor, known as natriuretic peptide receptor A (NPRA).

The findings appeared online recently in the journal Stem Cells.

"Our results show that NRPA signaling by cancer cells produces some molecular factors that attract stem cells, which in turn form blood vessels that provide oxygen and nutrients to the tumor," said the study's principal investigator Subhra Mohapatra, PhD, associate professor in the Department of Molecular Medicine. "We showed that if the NPRA signal is blocked, so is the angiogenesis and, if the tumor's blood supply is cut off it will die."

Using both cultured cells and a mouse model, Dr. Mohapatra and her team modeled interactions to study the association between gene mutations and exposure to an inflammatory tissue microenvironment.

The researchers demonstrated that cardiac hormone NRPA played a key role in the link between inflammation and the development of cancer-causing tumors. Mice lacking NPRA signaling failed to induce tumors. However, co-implanting tumor cells with mesenchymal stem cells, which can turn into cells lining the inner walls of blood vessels, promoted the sprouting of blood vessels (angiogenesis) needed to promote tumor growth in NPRA-deficient mice, the researchers found. Furthermore, they showed that NRPA signaling appears to regulate key inflammatory cytokines involved in attracting these stem cells to tumor cells.

Dr. Mohapatra's laboratory is testing an innovative drug delivery system using special nanoparticles to specifically target cancers cells like a guided missile, while sparing healthy cells. The treatment is intended to deliver a package of molecules that interferes with the cardiac hormone receptor's ability to signal.


'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3303
University of South Florida (USF Health)
Source:Eurekalert

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2017)... ... August 21, 2017 , ... PIXACORE , an ... one of the Top 100 agencies of the year by MM&M. , This is ... issue, marking an important milestone for the agency. PIXACORE’s newfound recognition reflects its ...
(Date:8/21/2017)... ... August 21, 2017 , ... The Industrial Designers Society of ... 2017 Ceremony and Gala on Aug. 19, 2017 in Atlanta, GA—revealing which 25 ... most prestigious and rigorous design competitions. See all the winners at http://www.idsa.org/awards/idea/gallery . ...
(Date:8/20/2017)... ... , ... Are you an adult with gluten intolerance or Celiac disease living ... in participating in a research study that focuses on family interactions when dealing with ... relational aspects of adults who have gluten sensitivities who cohabitate with other adults who ...
(Date:8/19/2017)... ... August 18, 2017 , ... President Donald Trump signed into ... provides for greater public access to over-the-counter (OTC) hearing aids. , The measure ... aids without being seen by a certified and licensed audiologist. , “The ...
(Date:8/19/2017)... (PRWEB) , ... August 19, 2017 , ... Yesterday, the ... KKK by saying there are two sides. There are not two sides to hatred, ... to rationalize violence and prejudice, and the NPEIV stands against all forms of such ...
Breaking Medicine News(10 mins):
(Date:8/17/2017)... 17, 2017 DarioHealth Corp. (NASDAQ: DRIO), ... health and big data solutions, announced today that ... and non-U.S. investors for the sale of shares ... the Company,s newly designated Series B Convertible Preferred ... expects to conduct a closing with respect to ...
(Date:8/15/2017)... 15, 2017 AccuGenomics, Inc., a diagnostic company ... announced that the company has provided an AccuKit to ... Carolina at Chapel Hill and to Qura Therapeutics for ... and quantify HIV reservoir and viral expression in human ... HIV Cure Center is a joint initiative between the ...
(Date:8/8/2017)... -- BioLineRx Ltd. (NASDAQ/TASE: BLRX), a clinical-stage biopharmaceutical company focused ... for the second quarter ended June 30, 2017. ... and to date: ... Company,s lead project, BL-8040: Announced plans ... novel stem cell mobilization treatment for autologous bone-marrow transplantation ...
Breaking Medicine Technology: