Navigation Links
Study links carcinogens to cancer stem cells -- but spinach can help
Date:6/20/2012

CORVALLIS, Ore. Researchers at Oregon State University for the first time have traced the actions of a known carcinogen in cooked meat to its complex biological effects on microRNA and cancer stem cells.

The findings are part of a growing awareness of the role of epigenetics in cancer, or the ways in which gene expression and cell behavior can be changed even though DNA sequence information is unaltered.

The scientists also found that consumption of spinach can partially offset the damaging effects of the carcinogen. In tests with laboratory animals, it cut the incidence of colon tumors almost in half, from 58 percent to 32 percent.

The research at OSU's Linus Pauling Institute was recently reported in the journal Molecular Nutrition and Food Research, in work supported by the National Institutes of Health.

"Cancer development is a complex, multi-step process, with damaged cells arising through various means," said Mansi Parasramka, a postdoctoral scholar with LPI. "This study showed that alterations of microRNAs affect cancer stem cell markers in colon cancer formation.

"MicroRNAs are very small factors that do very big things in cells," she said.

Traditionally, cancer was thought to be caused by changes in DNA sequence, or mutations, that allowed for uncontrolled cell growth. That's still true. However, there's also increasing interest in the role played by epigenetics, in which such factors as diet, environmental toxins, and lifestyle affect the expression of genes not just in cancer, but also cardiovascular disease, diabetes, and neurological disorders.

Included in this epigenetic equation is the formation of microRNAs once thought to be "junk DNA" - which researchers were at a loss to understand. It's now known that they influence which areas of DNA get expressed or silenced.

There are hundreds of microRNAs, and the OSU scientists monitored 679 in their experiments. When t
'/>"/>

Contact: Rod Dashwood
rod.dashwood@oregonstate.edu
541-737-8101
Oregon State University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/2/2014)... HealthDay Reporter WEDNESDAY, Oct. 1, ... the stops to rescue surgical patients in crisis are ... such heroism is questionable, a new study suggests. ... saving elderly patients with life-threatening complications after major surgery, ... senior author Dr. Amir Ghaferi. He is assistant professor ...
(Date:10/1/2014)... The peptide a small protein beta-amyloid is strongly associated ... unequivocal proof that this peptide is the causal agent ... main obstacle impeding such confirmation is that beta-amyloid is ... it aggregates, that is when it self-assembles to form ... with a single target, beta-amyloid alone, but with multiple ...
(Date:10/1/2014)... New research co-funded by the Engineering and Physical ... cyber-security of the UK,s vital industrial control systems ... the electricity grid, and the rail network. ... threats from hackers or malware infiltrating the systems ... Research Institute in Trustworthy Industrial Control Systems (RITICS), ...
(Date:10/1/2014)... 2014 Familylifeinsurancequotes.org has released a ... for senior citizens. , Senior citizens can qualify ... sell coverage to seniors who are over 50 years ... without taking a medical examination. , Term life insurance ... senior clients can qualify. Having life insurance during retirement ...
(Date:10/1/2014)... 01, 2014 Lifeinsurance-policy.com has released ... best life insurance prices for smokers. , Smoking will ... premiums. Comparing quotes is the best method to find ... for customers who need coverage. , Whole life ... of the policy. Since the coverage is permanent, the ...
Breaking Medicine News(10 mins):Health News:'High-Intensity' Hospitals Save More Elderly After Surgery: Study 2Health News:'High-Intensity' Hospitals Save More Elderly After Surgery: Study 3Health News:Laying siege to beta-amyloid, the key protein in Alzheimer's disease 2Health News:£2.5 million to recognize and reduce cyber-attack threats to critical infrastructure 2Health News:Affordable Term Life Insurance - Senior Citizens Can Qualify for Coverage! 2Health News:Affordable Whole Life Insurance Premiums for Smokers! 2
... to Integrate with MEDITECH MAGIC Health Information System via ... Information Management , , ... STRM ) today announced that it will ... MEDITECH MAGIC Health Information System of Massena Memorial Hospital, ...
... Dec. 9 Frost & Sullivan, a global ... recently held Manufacturing Summit, hosted the India Manufacturing ... Bangalore. Instituted in 2004, the awards aim to ... manufacturing capabilities and acknowledge the best facilities in ...
... the recent economic downturn, natural health degree ... still experiencing a wellness boom, as holistic ... the Internet,s top natural health career site ... training, chiropractic, nutrition, Reiki and reflexology career ...
... spend weeks in recovery after cosmetic skin treatments can often return ... thanks to an innovative new tool. The Pixel CO2 OMNIFIT device ... three. The technology is among the latest treatment tools available to ... ...
... Roche Molecular Diagnostics,announced today that it has received ... TaqMan(R) HBV Test v2.0, allowing it to be sold,for ... sensitive test offers,Roche,s fully automated real-time PCR technology to ... hepatitis B virus (HBV) DNA in patient,plasma and serum. ...
... Duane Reade Holdings, Inc. today announced the appointment of Mr. ... effective December 1, 2008. Mr. Scorpiniti reports directly to ... adds value and expertise to Duane Reade,s capable management team ... senior executives. , , ...
Cached Medicine News:Health News:Streamline Health(R) Announces Massena Memorial Hospital to Implement Enterprise Document Workflow Solutions 2Health News:Streamline Health(R) Announces Massena Memorial Hospital to Implement Enterprise Document Workflow Solutions 3Health News:Streamline Health(R) Announces Massena Memorial Hospital to Implement Enterprise Document Workflow Solutions 4Health News:Streamline Health(R) Announces Massena Memorial Hospital to Implement Enterprise Document Workflow Solutions 5Health News:Excellence in Supply Chain and Manufacturing Recognized at Frost & Sullivan's India Manufacturing Excellence Awards 2008 2Health News:Excellence in Supply Chain and Manufacturing Recognized at Frost & Sullivan's India Manufacturing Excellence Awards 2008 3Health News:Excellence in Supply Chain and Manufacturing Recognized at Frost & Sullivan's India Manufacturing Excellence Awards 2008 4Health News:Excellence in Supply Chain and Manufacturing Recognized at Frost & Sullivan's India Manufacturing Excellence Awards 2008 5Health News:Natural Healers Researches Natural Health Careers to Make the Prospective Holistic Health Students' Job Easier 2Health News:Natural Healers Researches Natural Health Careers to Make the Prospective Holistic Health Students' Job Easier 3Health News:Juva Skin Center's Laser Skin Treatments Take an Innovative Leap with Pixel CO2 Device 2Health News:Improved Testing for Hepatitis B Virus From Roche 2Health News:Improved Testing for Hepatitis B Virus From Roche 3Health News:Duane Reade Holdings, Inc. Further Strengthens Management Team With Addition of Frank Scorpiniti, SVP, Pharmacy Operations 2Health News:Duane Reade Holdings, Inc. Further Strengthens Management Team With Addition of Frank Scorpiniti, SVP, Pharmacy Operations 3
(Date:9/30/2014)... , Sept. 30, 2014 MiMedx Group, ... medicine company utilizing human amniotic tissue and patent-protected processes ... the Wound Care, Surgical, Orthopedic, Spinal, Sports Medicine, Ophthalmic ... Tom Koob , Ph.D., Chief Scientific Officer, will present ... Koob will present on Tuesday, October 7, 2014, at ...
(Date:9/30/2014)... 30, 2014 Arbor Pharmaceuticals, LLC. - ... Global Markets Direct,s, ,Arbor Pharmaceuticals, LLC. - Product ... the Arbor Pharmaceuticals, LLC.,s pharmaceutical research and development ... the current therapeutic developmental pipeline of Arbor Pharmaceuticals, ... therapeutics assessment by drug target, mechanism of action ...
(Date:9/30/2014)... DENVER , Sept. 30, 2014  According ... "the world of cancer clinical trials is going ... clinical trials and the work of the current ... these types of ,next generation, clinical trials, which ... tomorrow."  The company has been ...
Breaking Medicine Technology:MiMedx to Present at the Stem Cell Meeting on the Mesa 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 3Small Denver Company Pharmatech driving a large revolution in how cancer clinical trials are managed 2
... Reportlinker.com announces that a new market research ... Neurostimulation Devices - Global Pipeline ... 2016 http://www.reportlinker.com/p0285077/Neurostimulation-Devices---Global-Pipeline-Analysis--Opportunity-Assessment-and-Market-Forecasts-to-2016.html ... Pipeline Analysis, Opportunity Assessment and Market Forecasts ...
... announces that a new market research report is ... Dysfunction - Pipeline Assessment and Market Forecasts to ... Erectile Dysfunction - Pipeline Assessment and Market ... and healthcare report, "Erectile Dysfunction - Pipeline Assessment ...
Cached Medicine Technology:Reportlinker Adds Neurostimulation Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 2Reportlinker Adds Neurostimulation Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 3Reportlinker Adds Neurostimulation Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 4Reportlinker Adds Neurostimulation Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 5Reportlinker Adds Neurostimulation Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 6Reportlinker Adds Neurostimulation Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 7Reportlinker Adds Neurostimulation Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 8Reportlinker Adds Neurostimulation Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 9Reportlinker Adds Neurostimulation Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 10Reportlinker Adds Neurostimulation Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 11Reportlinker Adds Erectile Dysfunction - Pipeline Assessment and Market Forecasts to 2017 2Reportlinker Adds Erectile Dysfunction - Pipeline Assessment and Market Forecasts to 2017 3Reportlinker Adds Erectile Dysfunction - Pipeline Assessment and Market Forecasts to 2017 4Reportlinker Adds Erectile Dysfunction - Pipeline Assessment and Market Forecasts to 2017 5Reportlinker Adds Erectile Dysfunction - Pipeline Assessment and Market Forecasts to 2017 6
... Dornier Compact Delta lithotripsy system features real value ... systems shock source and C-arm are fully integrated ... risk of misalignment. The therapy head on the ... lateral and horizontal movement and can treat in ...
Used for male external catheterization due to urinary incontinence. The inflatable retention ring secures the catheter and can be easily deflated for removal. Supplied non-sterile. Reusable. Intended...
The latex free, hydrophilic Self-Cath Plus is designed for single use, intermittent self-catheterization. The unique hydrophilic coating activates immediately upon exposure to water for fast, clean...
The latex free, hydrophilic Self-Cath Plus is designed for single use, intermittent self-catheterization. The unique hydrophilic coating activates immediately upon exposure to water for fast, clean...
Medicine Products: