Navigation Links
Study links breast cancer risk to early-life diet and metabolic syndrome

Striking new evidence suggesting that diet and related factors early in life can boost the risk for breast cancer -- totally independent of the body's production of the hormone estrogen -- has been uncovered by a team of researchers at the University of California, Davis.

The findings provide new insights into the processes that regulate normal breast development, which can impact the risk of developing breast cancer later in life. The study will be published Sept. 17 in the early edition of the Proceedings of the National Academy of Sciences.

"It's long been assumed that circulating estrogens from the ovaries, which underlie normal female reproductive development, were crucial for the onset of breast growth and development," said Russ Hovey, a UC Davis associate professor of animal science and senior author on the study.

"Our findings, however, suggest that diet and shifts in body metabolism that parallel changes seen during obesity and Type 2 diabetes can also stimulate breast growth entirely independent of estrogen's effects," he said.

The studies with mice used a diet supplemented with a form of the fatty acid known as 10, 12 conjugated linoleic acid or 10, 12 CLA, which mimics specific aspects of a broader metabolic syndrome.

In humans, this syndrome is linked to a broad array of changes associated with obesity that can increase the risk of Type 2 diabetes and cardiovascular disease.

The 10, 12 CLA was added to the diet of the test group of mice because it is known to disrupt normal metabolic processes. In this study, the supplement stimulated the mammary ducts to grow, despite the fact that the mice lacked estrogen.

The researchers demonstrated that the diet-induced breast development also increased the formation of mammary tumors in some of the mice.

They ruled out a role for estrogen as the possible cause for how diet increased growth of the breast tissues by giving the supplement to male mice and to female mice in which the function of estrogen was blocked.

The research team also discovered that various mouse strains responded differently to the dietary supplement despite similar metabolic changes, suggesting that there may be a genetic component for how diet and related metabolic changes affect breast cancer risk in different populations, Hovey said.

He noted that results from the study would likely have significant implications for better understanding human breast development before puberty and after menopause, when estrogens are less present.

"The findings of this study are particularly important when we superimpose them on data showing that girls are experiencing breast development at earlier ages, coincident with a growing epidemic of childhood obesity," Hovey said.

Contact: Patricia Bailey
University of California - Davis

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... On Friday, ... presented a Bronze Wellness at Work award to iHire in recognition of their exemplary ... part of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set ... drug or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, ... traumatic event. , Trauma sufferers tend to feel a range of emotions, from depression, ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association ... it will receive two significant new grants to support its work to advance ... 25th anniversary by recognizing patients, medical professionals and scientists for their work in ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... at the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, ... journal articles published in Emergency Medicine Practice and Pediatric Emergency Medicine ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Ontario , June 27, 2016  VMS Rehab ... Company,s Board will take whatever measures required to build ... Company,s stock which is currently listed on the OTC ... Wexler, Company Chairman and CEO, "We are seeing an ... difficult to understand, not only by the Company, but ...
(Date:6/24/2016)... FRANCISCO, Calif. , June 24, 2016 /PRNewswire/ ... ), a biopharmaceutical company developing novel therapeutics for ... unmet needs, today announced the closing of its ... of common stock, at the public offering price ... in the offering were offered by GBT. GBT ...
(Date:6/24/2016)... , June 24, 2016 The Academy ... of recommendations that would allow biopharmaceutical companies ... with entities that make formulary and coverage decisions, a ... "value" of new medicines. The recommendations address ... not appear on the drug label, a prohibition that ...
Breaking Medicine Technology: