Navigation Links
Study linking gut microbe type with diet has implications for fighting GI disorders
Date:9/2/2011

PHILADELPHIA "You are what you eat" is familiar enough, but how deep do the implications go? An interdisciplinary group of investigators from the Perelman School of Medicine at the University of Pennsylvania have found an association between long-term dietary patterns and the bacteria of the human gut. In a study of 98 healthy volunteers, the gut bacteria separated into two distinct groups, called enterotypes, that were associated with long-term consumption of either a typical Western diet rich in meat and fat versus a more agrarian diet rich in plant material. A subsequent controlled-feeding study of 10 subjects showed that gut microbiome composition changed detectably within 24 hours of initiating a high fat/low fiber or low fat/high fiber diet, but that the enterotype identity of the microbe group remained stable during the 10-day study, emphasizing the short-term stability of the enterotypes. The findings were published this week in Science Express, and may have implications for exploring the relationship between diet and therapies for gastriinstesinal dosirders.

"It's well known that diet strongly affects human health, but how diet influences health is not fully understood," says Frederic D. Bushman, PhD, professor of Microbiology , who led the study together with co-principle investigators James Lewis, MD, MSCE, professor of Medicine in the Division of Gastroenterology and professor of Epidemiology, and Gary Wu, MD, professor of Medicine in the Division of Gastroenterology. "We found that diet is linked to the types of microbes in the gut, which provides a potential mechanism connecting diet with health."

Wu noted, "Although the mechanisms by which diet influences gut microbes remain to be fully characterized, our findings also provide insights into the differences in the types of gut bacteria observed in various societies across the globe."

The team used diet inventories surveys that catalog what people have eaten in the last 24 hours and also what they usually eat long-term - and compared that to sequenced DNA from stool samples from 98 healthy individuals. The sequencing allowed the researchers to count and identify gut bacteria. Fecal bacterial communities clustered into two broad groups, or enterotypes, distinguished primarily by levels of Bacteroides and Prevotella.

The enterotypes were strongly associated with diet, particularly protein and animal fat (Bacteroides genus) versus carbohydrates (Prevotella genus). Both Bacteroides and Prevotella are broad genera of bacteria species that typically live in the human gut. Humans tend to have mostly a species from one bacterial group but not both. Vegetarians were more likely to be in the Prevotella group, the enterotype associated with diets enriched in carbohydrates and lacking meat, and the one vegan was also in the Prevotella group.

Subsequently, 10 healthy volunteers were enrolled in a controlled feeding experiment in which their diets were fixed for a 10-day period. All ten subjects in the controlled-feeding experiment were in the Bacteroides group at the start, during, and at the end of the experiment. Their gut microbiomes changed within one day but stayed within the same broad Bacteroides group, even if they ate a diet high in carbohydrates over the 10-day period, emphasizing the short-term stability of the enterotypes.

There are several potential applications of this research. The Penn investigators are currently exploring the relationship between dietary therapies for Crohn's and the composition of the gut microbiome.

"Crohn's disease is caused in part by the way our body responds to the microbes in our intestines," explains Lewis. "Dietary therapies are different from most other Crohn's disease therapies because the dietary therapies don't suppress the immune system. One hypothesis is that these dietary therapies work by changing what organisms live in the intestines."

Roughly 1.5 million people in the United States suffer from ulcerative colitis or Crohn's disease, whose symptoms include abdominal pain, bleeding, nausea, and diarrhea.

The next line of study will be to identify changes in microbial composition associated with successful dietary intervention for these diseases , then optimize ways of creating these changes for improved therapy.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Related medicine news :

1. Memory Development Incomplete Until Adulthood: Study
2. U of T study suggests sexual orientation unconsciously affects our impressions of others
3. McMaster study finds more gut reaction to arthritis drugs
4. Lung cancer ALK rearrangement may predict pemetrexed efficacy, study shows
5. Alcohol dulls brain alarm that monitors mistakes, MU study finds
6. Mouse Study Could Give New Clues to Fighting Baldness
7. Longer CPR Backfires for Certain Heart Patients: Study
8. Potatoes May Be Good for the Heart After All, Study Says
9. Aging eyes linked to sleepless nights, new study shows
10. Insomnia costing US workforce $63.2 billion a year in lost productivity, study shows
11. Radiologists urged to study federal regulations relating to meaningful use
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... , ... June 24, 2016 , ... Finally, a bruise ... venous procedures, dermaka cream can be incorporated into the post-surgical treatment plans of a ... procedures. , dermaka cream is very effective for bruising and causes a rapid ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Today, InhaleLabs.com ... the ingestion of their medication by matching users with high quality water pipes within ... pieces with no commitment. , Inhale was founded by two brothers, Nick and Mike ...
(Date:6/23/2016)... ... 23, 2016 , ... Terumo BCT, a global medical device ... transfusion research programs and for the blood supply in the Netherlands, today announced ... Rating Score (PREPAReS) study. , Currently in its sixth year, the PREPAReS ...
(Date:6/23/2016)... ... ... The Mechille Wilson Agency, a Texas-based insurance company that provides coverage to ... initiating a charity drive to assist a student to be chosen from the local ... will be presented to the chosen student to help with the growing costs of ...
(Date:6/23/2016)... ... 23, 2016 , ... Representatives of CHA Fertility Centers (CFC), one of the ... Dr. Joshua J. Berger. As of May 2016, Dr. Berger will serve as ... Berger has received recognition for his research, his teaching and his patient care. After ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016 /PRNewswire/ ... pulmonary function testing company, is now able to perform sophisticated lung ... ndd Medical Technologies , Inc. Patients are ... labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients like ... any needed testing done in the comfort of her own home. ...
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... June 23, 2016  In a startling report released today, ... residents by lacking a comprehensive, proven plan to eliminate prescription opioid ... ranking of how states are tackling the worst drug crisis in ... states – Kentucky , New Mexico ... . Of the 28 failing states, three – ...
Breaking Medicine Technology: