Navigation Links
Study indicates grape seed extract may reduce cognitive decline associated with Alzheimer's disease

A compound found in grape seed extract reduces plaque formation and resulting cognitive impairment in an animal model of Alzheimer's disease, new research shows. The study appears in the June 18 issue of The Journal of Neuroscience.

Lead study author Giulio Pasinetti, MD, PhD, of Mount Sinai School of Medicine and colleagues found that the grape seed extract prevents amyloid beta accumulation in cells, suggesting that it may block the formation of plaques. In Alzheimer's disease, amyloid beta accumulates to form toxic plaques that disrupt normal brain function.

The researchers tested a grape seed polyphenolic extract product sold as MegaNatural-AZ, made by Polyphenolics, which in part supported the study. Polyphenolic compounds are antioxidants naturally found in wine, tea, chocolate, and some fruits and vegetables. To determine whether the extract could mitigate the effects of Alzheimer's disease, the researchers used mice genetically modified to develop a condition similar to Alzheimer's disease. They exposed pre-symptomatic "Alzheimer's mice" to the extract or placebo daily for five months. The daily dose of the polyphenolic extract was equivalent to the average amount of polyphenolics consumed by a person on a daily basis.

After the five-month period, Alzheimer's mice were at an age at which they normally develop signs of disease. However, the extract exposure reduced amyloid beta accumulation and plaque formation in brains of Alzheimer's mice and also reduced cognitive decline: compared to placebo, extract-exposed Alzheimer's mice showed improved spatial memory. These data suggest that before symptoms begin, the grape seed extract may prevent or postpone plaque formation and slow cognitive deterioration associated with Alzheimer's disease.

Moderate consumption of red wineapproximately one glass for women and two glasses for men, according to the Food and Drug Administrationand its constituent grape compounds has reported health benefits, particularly for cardiovascular function. Pasinetti previously found that red wine reduced cognitive decline in mice genetically modified to develop Alzheimer's disease. In subsequent studies, Pasinetti and colleagues have attempted to isolate which of the nearly 5,000 molecules contained in red wine are important in disease prevention. "Our intent is to develop a highly tolerable, nontoxic, orally available treatment for the prevention and treatment of Alzeheimer's dementia," Pasinetti said.

"The potential of natural compounds to provide real health benefits to brain function is only now beginning to be realized by brain researchers. The lesson they may eventually learn is that sometimes you just can't improve upon Mother nature," said Gary Arendash, PhD, of The Byrd Alzheimer's Institute, an expert unaffiliated with the study.

Chemical analysis showed that the major polyphenol components in the study's grape seed extract product are catechin and epicatechin, which are also abundant in tea and cocoa. These components differ from resveratrol, a polyphenol that has been reported to reduce amyloid beta secretion in cells and generally increase lifespan by mimicking calorie restriction. Resveratrol appears to be effective only at extremely high doses, which may limit its use in people. In contrast, the catechins in the extract product studied appear to be effective at much lower doses.

Karen Hsiao Ashe, MD, PhD, at the University of Minnesota and Minneapolis VA Medical Center, another expert unaffiliated with the study, cautioned that additional research must be completed before these findings translate to a human population. "Unanswered questions pertaining to the polyphenolic extract's use in humans to prevent Alzheimer's disease include: when to start taking it, for how long, how much to take, and most importantly, how does a person know if it is helping to prevent the aggregation of amyloid beta protein in the brain? These questions must be answered before polyphenolics can be recommended as a preventive measure for Alzheimer's disease," Ashe said.


Contact: Todd Bentsen
Society for Neuroscience

Related medicine news :

1. Study Ties Herpes Virus to Emerging Form of Diabetes
2. Study underway to find an alternative cure for Crohns disease and ulcerative colitis
3. New study shows American Cancer Society program helps employers
4. New study shows potential to treat or prevent viral cancers
5. Harvard Study in Joint Commission Journal: Mortality Rates Lower in Leapfrog Hospitals
6. Emory study of syphilis bacteria yields valuable diagnostic tool
7. New NV Economic Study: Bush Medicare Cuts Undermine State and Local Economic, Jobs Base
8. Benchmarking Study Report on Sales Performance Management
9. UltraShape(R) Commences Pivotal Study for First Non-Invasive Fat Reduction and Body Contouring Device Using Non-Thermal Selective Focused Ultrasound
10. Study pinpoints strategies that protect older adults physical health
11. NIH study concludes next weeks summer chorus camp for seniors improves quality of life
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... Additional breast cancers found with ... according to a study published online in the journal Radiology. Researchers said that ... necessitate a change in treatment. , Breast MRI is the most sensitive technique ...
(Date:11/25/2015)... ... November 25, 2015 , ... Finnleo, a leader in the traditional and far-infrared ... traditional and far-infrared saunas. , For traditional saunas, Finnleo is offering ... sauna wood, and Finnleo uses only European Grade A Nordic White Spruce from sustainably ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dr. John Pierce, Medical Director ... about hair loss treatment with the Capillus272™ Pro laser therapy cap. FDA cleared for ... and fuller hair, without the need for surgery, prescription pills, or topical foams. ...
(Date:11/25/2015)... ... ... For the first time, Vitalalert is donating half of its earnings to ... between the two groups began in 2014 with Vitalalert pledging a portion of every ... founded in 1954 and is an international Christian-based health organization whose mission is to ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dental professionals who would ... OH , are invited to attend Dr. Mark Iacobelli’s Advanced Implant Mentoring (AIM) CE ... Cleveland, OH. , As the co-founders of Advanced Implant Mentoring (AIM), Dr. Iacobelli ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 Research and Markets ( ... Wound Care Market by Type (Dressings, Therapy Devices, Active ... Facility, Out-Patient Facility), and Geography - Global Forecast to ... --> --> The purpose of ... forecast of the global advanced wound care market. It ...
(Date:11/26/2015)... , November 26, 2015 ... the "Self Administration of High Viscosity Drugs" ... ) has announced the addition of the ... report to their offering. --> Research ... addition of the "Self Administration of High ...
(Date:11/26/2015)... 26, 2015 ... of the  "2016 Future Horizons and ... Surface Marker Testing Market: Supplier Shares, ... their offering.  --> ... the  "2016 Future Horizons and Growth ...
Breaking Medicine Technology: