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Study in fruitflies strengthens connection among protein misfolding, sleep loss, and age
Date:2/20/2014

those costs is problems with protein folding."

Finally, and most importantly, she says these results suggest -- assuming they can be replicated in mice and humans that it may be possible using drugs such as PBA to "fix sleep" in aged or mutant animals.

"People know that sleep deteriorates with aging," Naidoo says, "But this might be able to be stopped or reversed with molecular chaperones." Her team is now looking to determine if a similar situation exists in mammals and if better sleep translates into longer lifespan.


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Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

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