Navigation Links
Study in fruitflies strengthens connection among protein misfolding, sleep loss, and age
Date:2/20/2014

lept less overall, and had their sleep more frequently interrupted compared to younger control animals. However, adding a molecule that promotes proper protein folding a molecular "chaperone" called PBA -- mitigated many of those effects, effectively giving the flies a more youthful sleep pattern. PBA (sodium 4-phenylbutyrate) is a compound currently used to treat such protein-misfolding-based diseases as Parkinson's and cystic fibrosis.

The team also asked the converse question: Can protein misfolding induce altered sleep patterns in young animals. Another drug, tunicamycin, induces protein misfolding and stress, and when the team fed it to young flies, their sleep patterns shifted towards those of aged flies, with less sleep overall, more interrupted sleep at night, and longer recovery from sleep deprivation.

Molecular analysis of sleep-deprived and PBA-treated flies suggested that PBA acts through the unfolded protein response. PBA, Naidoo says, had two effects on aged flies: it "consolidated" baseline sleep, increasing the total amount of time slept and shifted recovery sleep, after sleep deprivation, to look more like that of a young fly.

"It rescued the sleep patterns in the older flies," she explains.

These results, Naidoo says, suggest three key messages. First, sleep loss leads to protein misfolding and cellular stress, and as we age, our ability to recover from that stress decreases. Second, aging and sleep apparently form a kind of negative "chicken-and-egg" feedback loop, in which sleep loss or sleep fragmentation lead to cellular stress, followed by neuronal dysfunction, and finally even poorer-quality sleep.

Sleep recharges neuronal batteries, Naidoo explains, and if a person is forced to stay awake, those batteries run down. Dwindling physiological resources must be devoted to the most critical cell functions, which do not necessarily include protein homeostasis. "Staying awake has a cost, and one of
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Study shows gaps in inpatient psychiatry for Ontario youth
2. Bevacizumab offers no benefit for newly diagnosed glioblastoma, MD Anderson-led study finds
3. Study shows in vivo endomicroscopy improves detection of Barretts esophagus-related neoplasia
4. Cell therapy shows remarkable ability to eradicate cancer in clinical study
5. Blood pressure medications given right after stroke not beneficial, study finds
6. More women receiving breast reconstruction after mastectomy, study finds
7. Miriam Hospital study shows social gaming site effective weight loss tool
8. Study points out inequalities in prescribing blood pressure meds
9. Blood test serves as crystal ball for heart transplant patients, UCLA-led study finds
10. Study uncovers surprising differences in brain activity of alcohol-dependent women
11. Tinnitus study signals advance in understanding link between loud sounds exposure and hearing loss
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study in fruitflies strengthens connection among protein misfolding, sleep loss, and age
(Date:4/23/2014)... Fairfax, Va., April 23, 2014 The American Society ... guideline, "The Role of Postoperative Radiation Therapy for ... the use of adjuvant radiation therapy in the ... is published in the May-June 2014 issue of ... clinical practice journal of ASTRO. The full-length guideline ...
(Date:4/23/2014)... compound that targets an important brain receptor has a ... including relapse behavior, a University at Buffalo animal study ... this may be a novel lead compound for treating ... UB research was published as an online preview article ... study, the compound, RO5263397, severely blunted a broad range ...
(Date:4/23/2014)... "simple and accessible detection methods that can rapidly ... of a single cell inside that population has ... Chang Lu. , In the Royal Society of ... announced that he and his coworkers have developed ... of a protein ( Chem. Sci. , 2014, ...
(Date:4/23/2014)... the United States, it may come as a surprise that ... food due to lack of money or other financial resources. ... University of Illinois using data from the National Health and ... dealing with hunger are also facing negative health and nutrition ... age 60 faced the threat of hungerthat translates to 4.8 ...
(Date:4/23/2014)... Occupational and Leisure Time Physical Activity on Mobility Limitation ... midlife increases the risk of mobility limitation in old ... is found in a study which followed up 5,200 ... conducted at the Gerontology Research Center in Finland and ... labor is often repetitive, wears the body and lasts ...
Breaking Medicine News(10 mins):Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 3Health News:Novel compound halts cocaine addiction and relapse behaviors 2Health News:Following a protein's travel inside cells is key to improving patient monitoring, drug development 2Health News:More Americans in their golden years are going hungry 2Health News:Midlife occupational and leisure-time physical activity limits mobility in old age 2
... technique could pave the way toward screening people at ... may foreshadow malignancies, researchers from the University of Colorado ... in cancer is prevention, said researcher Wilbur A. Franklin, ... Health Sciences Center. Our goal would be to develop ...
... Dr. Peter Farrell to remain Chairman of the Board, ... RMD ),announced today that its board of directors ... the company. Effective January,1, 2008, Kieran T. Gallahue will ... board of directors. Mr. Gallahue, 44, will succeed Dr. ...
... United States,Government, through the U.S. Agency for International ... in equipment and technical,assistance to the Government of ... This announcement follows the provision of an initial ... Hellenic Red Cross for emergency,fire fighting equipment and ...
... members of SEIU UHW-West and 121RN, their, first ... hospital, BURBANK, Calif., Aug. 30 Caregivers at ... United Healthcare Workers -,West (UHW) and SEIU 121RN, reached ... Medical Center. The contract, which expires,Sept. 30, 2011, grants ...
... (ret), former White House National Drug Policy,Director (1996- 2001), ... widely cited terrorism and drug policy expert in the ... State Capitol rally for,recovery and treatment at 11 AM ... speaking will be California HHS Secretary Kimberly Belshe and,State ...
... Company Refuses to Pay Hospital ... Market-Competitive Rates, SAN DIEGO, ... against Blue Shield, the large insurance company,that is attempting to force ... "Blue Shield,s calculated and aggressive negotiating tactics are,designed to break ...
Cached Medicine News:Health News:New technique detects specific chromosomal damage, may indicate lung cancer risk 2Health News:ResMed Names Kieran Gallahue as Chief Executive Officer, Effective January 1, 2008. 2Health News:Providence St. Joseph Medical Center, Caregivers Reach Agreement on a Union Contract 2Health News:4-Star Gen. Barry Mccaffrey, Former U.S. Drug Czar, to Keynote 'Recovery Happens!' Rally for Treatment: Wed., Sept. 5, 11 Am, State Capitol West Steps, Sacramento 2Health News:Alvarado Hospital Files Countersuit Against Blue Shield 2Health News:Alvarado Hospital Files Countersuit Against Blue Shield 3
(Date:1/15/2014)... , Jan. 15, 2014 Massachusetts General Hospital ... AMGN ) announced today that they have ... validate new therapeutic targets and develop novel therapies ... that affects millions worldwide. The MGH-Broad-Amgen collaboration brings ...
(Date:1/15/2014)... 2014  Manufacturers, suppliers and distributors of innovative medical-related ... their most important business assets, intellectual property (IP). ... Because of the highly-competitive nature of the ... the most litigious industry sectors of cases involving ...
(Date:1/15/2014)... Inc. (Nasdaq: ECTE ) ("Echo"), a medical ... non-invasive, wireless continuous glucose monitoring system, today announced that ... CEO of Echo Therapeutics, will present at "TEN", Noble ... Mr. Doman will make a corporate presentation to ...
Breaking Medicine Technology:Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Intellectual Property Insurance for Medical-related Products and Services 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3
Ultrasonic Pachymeter UP-1000 is fast, accurate corneal thickness measurements....
... pachymeter, with large high resolution LCD touch ... 300P is a portable, digital pachymeter which ... of a high frequency, low noise probe ... immediately upon application of the probe along ...
... pachymeter, with compact LCD screen and optional ... portable, weighing slightly more than 2 lbs ... large liquid crystal display. The combination of ... fast precise algorithm enables measurement immediately upon ...
... mounted on a stick to make ... are 37 mm square. They are ... 50PD. Plus red square. Now shipping ... prism on stainless steel stick. Specify ...
Medicine Products: