Navigation Links
Study in fruitflies strengthens connection among protein misfolding, sleep loss, and age
Date:2/20/2014

PHILADELPHIA - Pulling an "all-nighter" before a big test is practically a rite of passage in college. Usually, it's no problem: You stay up all night, take the test, and then crash, rapidly catching up on lost sleep. But as we age, sleep patterns change, and our ability to recoup lost sleep diminishes.

Researchers at the Perelman School of Medicine, University of Pennsylvania, have been studying the molecular mechanisms underpinning sleep. Now they report that the pathways of aging and sleep intersect at the circuitry of a cellular stress response pathway, and that by tinkering with those connections, it may be possible to alter sleep patterns in the aged for the better at least in fruit flies.

Nirinjini Naidoo, PhD, associate professor in the Center for Sleep and Circadian Neurobiology and the Division of Sleep Medicine, led the study with postdoctoral fellow Marishka Brown, PhD, which was published online before print in the journal Neurobiology of Aging.

Increasing age is well known to disrupt sleep patterns in all sorts of ways. Elderly people sleep at night less than their younger counterparts and also sleep less well. Older individuals also tend to nap more during the day. Naidoo's lab previously reported that aging is associated with increasing levels of protein unfolding, a hallmark of cellular stress called the "unfolded protein response."

Protein misfolding is also a characteristic of several age-related neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, and as it turns out, also associated with sleep deprivation. Naidoo and her team wanted to know if rescuing proper protein folding behavior might counter some of the detrimental sleep patterns in elderly individuals.

Using a video monitoring system to compare the sleep habits of "young" (9󈝸 days old) and "aged" (8 weeks old) fruit flies, they found that aged flies took longer to recover from sleep deprivation, s
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Study shows gaps in inpatient psychiatry for Ontario youth
2. Bevacizumab offers no benefit for newly diagnosed glioblastoma, MD Anderson-led study finds
3. Study shows in vivo endomicroscopy improves detection of Barretts esophagus-related neoplasia
4. Cell therapy shows remarkable ability to eradicate cancer in clinical study
5. Blood pressure medications given right after stroke not beneficial, study finds
6. More women receiving breast reconstruction after mastectomy, study finds
7. Miriam Hospital study shows social gaming site effective weight loss tool
8. Study points out inequalities in prescribing blood pressure meds
9. Blood test serves as crystal ball for heart transplant patients, UCLA-led study finds
10. Study uncovers surprising differences in brain activity of alcohol-dependent women
11. Tinnitus study signals advance in understanding link between loud sounds exposure and hearing loss
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study in fruitflies strengthens connection among protein misfolding, sleep loss, and age
(Date:12/26/2014)... 2014 DW-InductionHeating.com (DaWei Induction Heating Co.) ... and developing, producing and marketing of a series of ... announces their new series of induction brazing equipments ... company, induction brazing refers to the joining ... material and heat. The manager says that there are ...
(Date:12/25/2014)... This is a professional and in-depth study ... with a focus on the Chinese market. The report ... Sterilizers manufacturers and is a valuable source of guidance ... industry. This report provides a basic overview of the ... this part, the report presents the company profile, product ...
(Date:12/25/2014)... TX (PRWEB) December 26, 2014 The ... to 2023” focuses on the current treatment landscape, unmet ... cancer market. TS-1 is an anti-cancer drug which is ... orally and is also used for treating gastric cancer ... and otastat potassium. The drug was first approved in ...
(Date:12/25/2014)... Recently, iFitDress.com, the popular online supplier of wedding dresses and ... of black one-shoulder cocktail dresses . In addition, all ... at discounted prices, up to 70% off. , ... weeks only. You know, we have thousands of frequent callers ... new items can visit our website for more details. The ...
(Date:12/25/2014)... Recently, BellasDress has launched its Christmas Sale, ... has chosen their best-selling lace wedding dresses, vintage bridesmaid ... season. , Now, BellasDress.com features popular women’s dresses, ... discount prices. The business hopes everyone can have a ... , “All our elegant products are made with exquisite ...
Breaking Medicine News(10 mins):Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 3Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2
... coordinate gene expression is a long-standing goal of ... multiple vertebrate or invertebrate // species holds promise ... dynamic interplay between a gene and its transcriptional ... based on the hypothesis that functionally important sequences ...
... all aspects of human behaviour; they impact upon the foods ... or avoid and the people with whom we spend time ... it has been proposed that the brain uses it as ... avoidance behaviors. Stimulus evaluation is also thought to be immediate, ...
... 70 percent of the children who live in non-fluoridated ... adequately fluoridated water. , ,These findings were arrived ... children. Jason Armfield, a researcher at the Australian Centre ... was categorical in saying that the study highlighted the ...
... for fish food to be cooked the right way to harness ... is as important as the amount of fat and calories in ... facts? Just one piece of batter-dipped fish has 170 calories and ... stuff, hushpuppies and coleslaw will probably give you 1,240 calories and ...
... suggested that therapeutics based on monoclonal antibodies (mAbs) are ... small molecule predecessors. According to a study completed by ... so fare appear to be profitable. That means mAbs ... billion to $1.8 billion cost of development and marketing. ...
... materialized by increasing cigarette taxes, raising the smoking age and ... youth smoking according to a researchers. // This ... people addicted to this habit. It is time that lawmakers ... research shows that reducing smoking initiation in youth is likely ...
Cached Medicine News:Health News:Evoprinter, a multigenomic comparative tool for rapid identification of functionally important DNA 2Health News:Conditioning preferences in children 2Health News:Therapeutic Monoclonal Antibody Production Is More Profitable Than Small Molecule Drugs 2Health News:Lawmakers alerted on new tobacco control policies by research team 2
(Date:12/24/2014)... 2014 LifeScienceIndustryResearch.com adds ... Syringe Industry of 178 pages providing 10 ... library. The 2014 Market Research ... a professional and deep research report on ... the report introduces Disposable Syringe basic information ...
(Date:12/24/2014)... -- Lockton Dunning Benefits, the Dallas ... of Vice President Kim Foerster on ... team, Excelsior Solutions. Foerster brings ... position.  Most recently, she worked as the Director ... where she has held various managerial positions since ...
(Date:12/24/2014)... BARBARA, Calif. , Dec. 23, 2014 In ... Junior Doctors, Association of Sierra Leone , ... Sierra Leone for the treatment of local health ... While a new dedicated Ebola care center was constructed ... virus, the facility is not available for local Sierra Leonean ...
Breaking Medicine Technology:World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5Kim Foerster Joins Lockton Companies 2First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2
... Pharmaceuticals, Inc. (NYSE Amex: INO ), a ... against cancers and infectious diseases, announced today that the ... technology at the 14th Annual Meeting of the American ... May 18-21 in Seattle, Washington at the Washington State ...
... Shenghuo Pharmaceutical Holdings, Inc. (NYSE Alternext US: KUN) ("China Shenghuo" ... first quarter ended March 31, 2011. F ... Highlights Total revenue increased to $9.4 million ... Net cash provided by operating activities was approximately $2.6 ...
Cached Medicine Technology:Inovio Pharmaceuticals to Present at American Society of Gene & Cell Therapy Annual Meeting May 18 - 21, 2011 2Inovio Pharmaceuticals to Present at American Society of Gene & Cell Therapy Annual Meeting May 18 - 21, 2011 3Inovio Pharmaceuticals to Present at American Society of Gene & Cell Therapy Annual Meeting May 18 - 21, 2011 4China Shenghuo Pharmaceutical Reports Financial Results for the First Quarter of 2011 2China Shenghuo Pharmaceutical Reports Financial Results for the First Quarter of 2011 3China Shenghuo Pharmaceutical Reports Financial Results for the First Quarter of 2011 4China Shenghuo Pharmaceutical Reports Financial Results for the First Quarter of 2011 5China Shenghuo Pharmaceutical Reports Financial Results for the First Quarter of 2011 6China Shenghuo Pharmaceutical Reports Financial Results for the First Quarter of 2011 7China Shenghuo Pharmaceutical Reports Financial Results for the First Quarter of 2011 8
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: