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Study in Circulation Research details how diabetes drives atherosclerosis
Date:3/13/2008

cells to fine-tune their control over proteins. In normal function, a cell may extend a proteins lifespan, or send it from one part of the cell to another, by attaching a SUMO tag. In the current study, researchers found that AGEs and H202 induced ERK5-SUMOylation as part of disease. In addition, the team found that ERK5-SUMOylation was increased in the aortas of diabetic mice.

Along with Abe, Chang-Hoon Woo, Tetsuro Shishido and Carolyn McClain contributed to the work within the Aab Cardiovascular Research Center. Jae Hyang Lim and Jian-Dong Li within the Department of Microbiology & Immunology at the Medical Center contributed expertise, along with Jay Yang, professor of Anesthesiology at Columbia University. This work is supported by grants from the America Heart Association and the National Institutes of Health.

Our experiments found that taking away the SUMO tag from ERK protects blood vessels against diabetes, Abe said. We believe that the SUMOylation of ERK turns off good genes that are important in countering atherosclerosis. In the next phase, we will be looking for drug candidates that can turn on ERK5 as diabetes attempts to shut it down.


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Contact: Greg Williams
Greg_Willams@urmc.rochester.edu
University of Rochester Medical Center
Source:Eurekalert

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