Navigation Links
Study implicates new epigenetic player in mental retardation and facial birth defects
Date:7/12/2010

the scientific literature, Qi and his collaborators, Madathia Sarkissian and Thomas Roberts at Dana-Farber Cancer Institute, tested the normal enzyme function in zebrafish, a popular model for genetic function.

It is hard to judge cognitive impairment in a small fish, but the dramatic impact on craniofacial development was obvious. Fish without the enzyme developed virtually no jawbone, a condition that could be prevented by providing the functioning enzyme, showing its importance in development. As importantly, providing more of the fish version of the MSX1 gene (whose activity the demethylase enzyme encourages) also partially prevented the biological defects caused by the missing enzyme.

Hope for the reversibility of some aspects of mental retardation arose three years ago in a Scottish mouse study of Rett syndrome, a disorder on the autism spectrum that is also a cause of severe mental retardation in girls. The disease is caused by a molecule, MeCP2, that binds to methylated DNA and may be involved in another form of epigenetic regulation.

"In practical terms, we use gene expression as a read out," says Shi, also a professor of pathology at Harvard Medical School. "Epigenetic states affect the expression of critical genes. These studies suggest that the imbalance of histone methylation dynamics plays a critical role in mental retardation. You can imagine a therapeutic approach to enhance the compromised enzymatic activity or to restore the downstream function."


'/>"/>

Contact: Erin McColgan
erin.mccolgan@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. LSUHSC study finds early predictors of metabolic syndrome in healthy 7-9 year-olds
2. New UC Davis study finds early Alzheimers identification method
3. Rat Study Sheds Light on Cocaine Addiction
4. Study: Medicare policy may account for growing length of hospice stays in nursing homes
5. Study Suggests Link Between HPV, Skin Cancer
6. Drug study shows improvement in major orthopedic surgery care
7. Study suggests link between scleroderma, cancer in certain patients
8. Fish Oil Supplements Linked to Lower Risk of Breast Cancer: Study
9. Study finds patients benefit from thorough discussion of recommended operations
10. Many Docs Deliver Cancer Diagnosis Badly: Study
11. Study: Higher-protein diets support weight loss, but may lower bone density in postmenopausal women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/2/2014)... Originally considered alternative food only ... increasingly popular with consumers. This has fuelled demand ... industry in Australia. According to IBISWorld industry ... has surged over the past five years, contributing ... level.” Over the five years through 2014-15, industry ...
(Date:10/2/2014)... Maureen Salamon HealthDay ... -- Middle-aged women with a neurotic personality style and ... Alzheimer,s disease, new research suggests. Tracking 800 women ... who were most anxious, jealous and moody -- which ... had double the risk of developing Alzheimer,s compared to ...
(Date:10/2/2014)... (HealthDay News) -- Children with autism are more sedentary ... of being more active, a small study suggests. ... children, some with autism and some without. Children with ... physical activity and 70 more minutes each day sitting ... autism scored lower on strength, but had similar body-mass ...
(Date:10/2/2014)... Amy Norton HealthDay Reporter WEDNESDAY, ... smelling the roses -- literally -- may face an increased risk ... In a study of over 3,000 older Americans, researchers found those ... peppermint were more than three times as likely to die in ... smell. In fact, anosmia -- the inability to distinguish odors ...
(Date:10/2/2014)... medical discovery by scientists at The University of Nottingham ... type of painkiller. , A drug resulting from the ... , would offer new hope to sufferers of chronic ... few effective painkillers are currently available. , The work, ... of Life Sciences, in collaboration with David Bates, Professor ...
Breaking Medicine News(10 mins):Health News:Organic Livestock and Poultry Farming in Australia Industry Market Research Report Now Available from IBISWorld 2Health News:Organic Livestock and Poultry Farming in Australia Industry Market Research Report Now Available from IBISWorld 3Health News:Organic Livestock and Poultry Farming in Australia Industry Market Research Report Now Available from IBISWorld 4Health News:Jealous, Moody Women May Face Higher Alzheimer's Risk, Study Says 2Health News:Jealous, Moody Women May Face Higher Alzheimer's Risk, Study Says 3Health News:Kids With Autism Tend to Be Less Active, Study Says 2Health News:Could a Fading Sense of Smell Point to Earlier Death? 2Health News:Could a Fading Sense of Smell Point to Earlier Death? 3Health News:Medical discovery first step on path to new painkillers 2
... PhD, president of The J. David Gladstone Institutes, ... The award recognizes his leadership as Gladstone,s founding ... one of the world,s foremost independent research institutions, ... impact on disease prevention. Mahley will be ...
... ... regarding 2010 Shanghai, China Expo -- attracting attention from all walks of life. , ... Beijing (PRWEB) February 10, 2010 -- ... biggest World Expo in the history of world expositions. , , ,This special tour has ...
... women don,t know it is leading killer, survey finds , ... almost half of all American women still don,t know that ... new research finds. , Even more concerning, only slightly more ... they were having heart attack symptoms, according to the latest ...
... with Inflammatory Bowel Disease (IBD) are known to be at high ... of their disease but now new research by scientists at The ... to hospital during flare-ups are also at risk. The two ... affect about one in every 250 people in the UK. The ...
... ... to learn how to differentiate from competition and manage risk. , ... Lafayette, CO (PRWEB) February 10, 2010 -- Auto dealers will be able ... lead-generation, HR best practices and OSHA regulations at the Orlando NADA Convention and Expo 2010., , ...
... Poll Finds Voters Prefer Tobacco Tax to Other Tax Increases, Budget Cuts ... Utah ,s cigarette tax by $1 per pack would bring ... the state,s budget shortfall, while also reducing smoking and saving lives, according ... organizations.  In Utah, health advocates are calling on state leaders to increase ...
Cached Medicine News:Health News:Gladstone's Robert Mahley to receive Research!America advocacy award 2Health News:Jion Beijing Great Wall International Travel Agency Immediate Exposure to China Expo 2010 2Health News:Women's Heart Disease Awareness Still Lacking 2Health News:Women's Heart Disease Awareness Still Lacking 3Health News:Bowel disease link to blood clots 2Health News:Bowel disease link to blood clots 3Health News:KPA and TK Carsites offer HR, OSHA and Internet Marketing Workshops at the NADA Convention and Expo 2010 2Health News:New Report: $1 Cigarette Tax Increase Would Raise $43.3 Million for Utah and Cut Youth Smoking 2Health News:New Report: $1 Cigarette Tax Increase Would Raise $43.3 Million for Utah and Cut Youth Smoking 3
(Date:10/2/2014)... Oct. 2, 2014   West Pharmaceutical Services, Inc. ... in innovative solutions for injectable drug administration, announced today ... include a new site in Waterford, Ireland ... for insulin injector cartridges and other high-value packaging components, ... biotech customers. Once operational, this new site could bring ...
(Date:10/1/2014)... DUBLIN, Ohio , Oct. 1, 2014 ... to shareholders is now available. Interested parties can ... and how Cardinal Health is supporting the ... at http://cardinalhealth.com/annualreport . Photo- ... addition to summary financials and the chief ...
(Date:10/1/2014)... 1, 2014  ResMed (NYSE: RMD ), a ... company to design complete sleep apnea solutions specifically for women, ... importance of a good night,s sleep. The ... that feeling tired is just part of living a busy ... a critical pillar of health, essential to not only living ...
Breaking Medicine Technology:West Announces Plans for a New Pharmaceutical Component Manufacturing Plant in Ireland 2West Announces Plans for a New Pharmaceutical Component Manufacturing Plant in Ireland 3West Announces Plans for a New Pharmaceutical Component Manufacturing Plant in Ireland 4West Announces Plans for a New Pharmaceutical Component Manufacturing Plant in Ireland 5Cardinal Health 2014 Digital Report to Shareholders Now Available 2ResMed Launches Initiative to Help Women Get Better Sleep 2ResMed Launches Initiative to Help Women Get Better Sleep 3
It provides excellent illumination from an inexpensive platform and is mounted on the comfortable UltraLite headband....
It is a fiberoptic based intracranial monitoring systems for continuous monitoring of pressure....
... The Polaris system delivers the most ... effective and easy to use, this ... of precision measurement with unprecedented tracking ... active and passive tools, the Polaris ...
Penfield Dissector #2...
Medicine Products: