Navigation Links
Study identifies underlying dysfunction of seemingly non-critical heart condition
Date:9/13/2010

lecular and cellular levels precede future dysfunction in these patients.

"Without clearly defined evidence supporting optimal care, clinicians are unable to predict which rVSD patients have an increased risk of a poor outcome," said Mark Gerhardt, MD, PhD, associate professor of Anesthesiology at the Ohio State University Medical Center and one of the study authors.

Using an animal model of rVSD, the team at Nationwide Children's Hospital and Ohio State University Medical Center discovered that although blood flow was normal in the models' heart, there were molecular changes, evidence of right ventricular diastolic dysfunction, and impairment of muscle contraction and relaxation at the cellular level.

"These data indicate that despite no overt dysfunction at the level of the whole heart, molecular remodeling and progressive diastolic dysfunction is nevertheless taking place," said Dr. Wold, also a faculty member at The Ohio State University College of Medicine.

"Right ventricular diastolic dysfunction in rVSD is a major finding of this study," said Dr. Gerhardt. "Because the right ventricle is a low-pressure system, small changes in right ventricular compliance may have significant clinical consequences. Our findings indicate that patients with rVSD should be carefully evaluated for right ventricular diastolic dysfunction."

The study also revealed upregulation of the cytoskeletal protein, desmin, in the wall of the right ventricle that precedes functional alterations.

"Desmin may represent a key early marker for future right ventricular dysfunction," said Dr. Wold. "Future research is warranted to determine if increased desmin is the cause or a reaction to diastolic dysfunction."

Findings from the study may lead to a fundamental change in the clinical management of rVSD by providing evidence for early repair of the defect.


'/>"/>

Contact: Mary Ellen Peacock
MaryEllen.Peacock@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... OH (PRWEB) March 03, 2015 ... to better predict antidepressant treatment outcomes for patients ... resources, than any of the individual genes that ... by investigators from the Mayo Clinic and Assurex ... i. , The proprietary technology of the ...
(Date:3/3/2015)... The number of couples experiencing infertility ... 15%. This increases to 50% by the time a ... Yuzpe AA, et al. Estimating the prevalence of infertility ... Hitkari, a reproductive endocrinologist and co-director at Olive Fertility ... clinical director and founder of Acubalance Wellness Centre will ...
(Date:3/3/2015)... With a grant of more than $4.5 ... has been named a national coordinating center by the ... for Health: Improving Community Health Through Innovations in Financing ... health and reduce disparities through innovations in collaboration and ... of the center and up to 10 communities over ...
(Date:3/3/2015)... 03, 2015 The Calistoga Chamber of Commerce ... All Weekends,” taking place Friday, March 27, through Sunday, March ... Muddy 5K fun run, restaurant and bar crawl, lodging and ... to women, ages 14 and older. , A variety of ... in on the action by offering Mudder of All Weekends ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 -- vRad ( ... radiology practice, today announced that Arlene Sussman, MD, a ... host a live webinar to explore how telemedicine best ... breast imaging services for women virtually anywhere. Click ... Imaging Service Line” on March 4, 2015 at 1:00 ...
Breaking Medicine News(10 mins):Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 2Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 3Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 4Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 5Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 6Health News:New Treatment Approach Helps Boost Chance of Pregnancy; Information Seminar at Olive Fertility Center 2Health News:New Treatment Approach Helps Boost Chance of Pregnancy; Information Seminar at Olive Fertility Center 3Health News:New Treatment Approach Helps Boost Chance of Pregnancy; Information Seminar at Olive Fertility Center 4Health News:Robert Wood Johnson Foundation Names Georgia Health Policy Center National Center for Bridging for Health Initiative 2Health News:Visit Calistoga Hosts Mudder of All Weekends Girlfriend Getaway Event 2Health News:Visit Calistoga Hosts Mudder of All Weekends Girlfriend Getaway Event 3Health News:Latest vRad Webinar: Building World-Class Breast Imaging Services Virtually Anywhere with Telemedicine Best Practices 2Health News:Latest vRad Webinar: Building World-Class Breast Imaging Services Virtually Anywhere with Telemedicine Best Practices 3Health News:Latest vRad Webinar: Building World-Class Breast Imaging Services Virtually Anywhere with Telemedicine Best Practices 4
... , WASHINGTON, Sept. 9 Former presidential ... care address said Tuesday that he would be listening for ... willing to make to show that his promises of bipartisan ... The chairman of the Campaign for Working Families made the ...
... , , , BOSTON and ... its causes, potential cures, current treatments and strategies for living well ... Macular Degeneration Symposium on September 17. A free public educational program, ... the Barnstable Senior Center, 825 Falmouth Road (Rt. 28) in Hyannis. ...
... FLEMINGTON, N.J., Sept. 9 HCD Research announced ... Barack Obama,s speech on health care reform tonight to obtain ... care reform. , , (Logo: ... HCD Research will conduct the study using its MediaCurves.com(R) website ...
... , , LAKE MARY, ... nation,s largest independent specialty pharmacy providers, was again chosen as ... is the fifth consecutive year that Axium has received this ... Business Journal recognizes the top 100 privately held companies in ...
... , , PRINCETON, N.J., Sept. 9 ... ) today announced the opening of new clinical development offices in Sao ... global footprint with a comprehensive range of services across Latin America. Earlier ... These new sites will support staff in these countries, Central America, and ...
... pandemic may have antiviral properties, scientists say, , WEDNESDAY, Sept. ... sap has components that show great efficacy in killing off ... plant, Ferula assa-foetida , grows throughout Iran, Afghanistan and ... due to its ill-smelling sap. But the researchers note that ...
Cached Medicine News:Health News:Bauer Calls for News of Concrete Compromise from President Obama 2Health News:First Cape Cod Macular Degeneration Symposium To Be Held on September 17 2Health News:First Cape Cod Macular Degeneration Symposium To Be Held on September 17 3Health News:Research Firm will Obtain Americans' Reactions to the President's Speech on Health Care Reform 2Health News:Axium Healthcare Pharmacy, Inc. Has Been Chosen as One of 'Central Florida's Golden 100 Companies' for the Fifth Year in a Row 2Health News:Covance Opens New Clinical Development Offices in Brazil and Mexico 2Health News:Covance Opens New Clinical Development Offices in Brazil and Mexico 3
(Date:3/3/2015)... AUSTIN, Texas , March 3, 2015  UnaliWear ... that provides advanced support for seniors that guards against ... The new wearable – the Kanega ... of its kind to use an easy speech interface ... update medical information without human input. ...
(Date:3/3/2015)... Mar. 03, 2015 Research and Markets ... "Global POC Diagnostics Market 2015-2019" report to ... the Global POC Diagnostics market to grow at a ... POC diagnostics are IVD devices and tools ... laboratory setting. The use of these devices helps in ...
(Date:3/3/2015)... , March 3, 2015  American Biosurgical, LLC ... medical cable manufacturer actively engaged in the design, ... for the world,s leading medical device companies has ... precision, low volume custom medical cable manufacturer based ... the MTI brand under the name MTI Medical ...
Breaking Medicine Technology:UnaliWear's Wearable For Seniors Extends Independence With Advanced Technology 2Global POC Diagnostics Market 2015-2019 with Abbott Labs, Alere, Bayer Healthcare, Danaher, F. Hoffmann-La Roche & Johnson & Johnson Dominating 2American Biosurgical Acquires MTI Corporation 2
... July 30 Zargis Medical Corp., a majority-owned subsidiary of ... Care System (VAPAHCS), a northern California based hospital group that ... hospitals, recently purchased 15 Zargis Cardioscan systems. , ... The VA Palo Alto Health Care System (VAPAHCS) consists ...
... 29 Sequenom, Inc. (Nasdaq: SQNM ), will report second quarter 2010 financial results after market close ... 1:30 pm Pacific Time ( 4:30 pm Eastern Time ) on the same day. , ... Information: , , , ... International callers: +1- 857-350-1603 , , ...
Cached Medicine Technology:Veterans Administration Health Care System Purchases 15 Zargis Cardioscan Systems 2Veterans Administration Health Care System Purchases 15 Zargis Cardioscan Systems 3Sequenom Announces Date of Second Quarter 2010 Financial Results and Conference Call 2
... Reference Series 2000 Pipette is a synonym ... compact and robust design, and superior operating ... to operate the measuring stroke and blow-out ... features:Eppendorf "pipette/tip" system ensures utmost accuracy and ...
... Pipette is a synonym for pipetting accuracy, ... design, and superior operating comfort. Its single, ... measuring stroke and blow-out as well as ... ensures utmost accuracy and precision. Ejection sleeve ...
... Finnpipette Focus from Thermo Labsystems ... ergonomics with uncompromising performance. ... offers a custom fit for ... shorter tip cones allow easier ...
... Testing System is the smallest blood glucose testing ... when you need it in your backpack ... simply in your purse or pocket.* Its small ... go. And, because it's so convenient it's easier ...
Medicine Products: