Navigation Links
Study identifies underlying dysfunction of seemingly non-critical heart condition
Date:9/13/2010

Repairing small, seemingly benign holes in a child's heart may be more clinically important than previously thought, as dysfunction could be lurking out of sight. These are the findings from a study conducted by doctors and researchers at Nationwide Children's Hospital and the Ohio State University Medical Center examining a subset of the most common form of congenital heart disease, ventricular septal defect. The recently published study appears in the Journal of Molecular and Cellular Cardiology, the official journal of the International Society for Heart Research.

Ventricular septal defect is a congenital heart defect defined by one or more holes in the wall that separates the right and left ventricles of the heart. These defects can be large (nonrestrictive) or small (restrictive) and vary in severity depending on size. Medical management of large ventricular septal defects is straightforward in that the hole must be closed or the patient will develop severe, life-threatening complications including pulmonary hypertension and right ventricle failure.

Management of a restrictive ventricular septal defect (rVSD) is less clear.

"rVSD patients typically have normal blood circulation despite an obvious defect and hole in the ventricular wall," said Loren Wold, PhD, FAHA, principal investigator in the Center for Cardiovascular and Pulmonary Research at The Research Institute at Nationwide Children's Hospital and one of the study authors. "Clinically, these patients are usually observed with the hope that the defect will close over time without the need for surgical repair and without the development of heart failure or sudden death."

Because rVSD is often considered to be hemodynamically benign, meaning that blood flow appears normal, it is assumed that whole heart function is a reflection of conditions at the cellular and molecular levels. Therefore, few studies have investigated whether changes in the heart at the molecular and cellular levels precede future dysfunction in these patients.

"Without clearly defined evidence supporting optimal care, clinicians are unable to predict which rVSD patients have an increased risk of a poor outcome," said Mark Gerhardt, MD, PhD, associate professor of Anesthesiology at the Ohio State University Medical Center and one of the study authors.

Using an animal model of rVSD, the team at Nationwide Children's Hospital and Ohio State University Medical Center discovered that although blood flow was normal in the models' heart, there were molecular changes, evidence of right ventricular diastolic dysfunction, and impairment of muscle contraction and relaxation at the cellular level.

"These data indicate that despite no overt dysfunction at the level of the whole heart, molecular remodeling and progressive diastolic dysfunction is nevertheless taking place," said Dr. Wold, also a faculty member at The Ohio State University College of Medicine.

"Right ventricular diastolic dysfunction in rVSD is a major finding of this study," said Dr. Gerhardt. "Because the right ventricle is a low-pressure system, small changes in right ventricular compliance may have significant clinical consequences. Our findings indicate that patients with rVSD should be carefully evaluated for right ventricular diastolic dysfunction."

The study also revealed upregulation of the cytoskeletal protein, desmin, in the wall of the right ventricle that precedes functional alterations.

"Desmin may represent a key early marker for future right ventricular dysfunction," said Dr. Wold. "Future research is warranted to determine if increased desmin is the cause or a reaction to diastolic dysfunction."

Findings from the study may lead to a fundamental change in the clinical management of rVSD by providing evidence for early repair of the defect.


'/>"/>

Contact: Mary Ellen Peacock
MaryEllen.Peacock@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... del Rey, CA (PRWEB) , ... August 22, ... ... of revenue cycle management (RCM) solutions, announced recently the availability of a new ... HIM community in appreciation for their service to the healthcare industry. E/M coding ...
(Date:8/22/2017)... ... ... Five Star Glass is new to the Texas market, but is proudly managed by widely ... makes and models, in Grand Prairie, TX, located in the center of the DFW Metroplex, ... owned business for the past 40 years with 32 convenient locations in Texas, Nevada and ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Wilderness Voices”: a collection of ... “Wilderness Voices” is the creation of published author, Martha McKown, an ordained United ... inspired as a very young child when her older sisters studied High School literature. ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Covert Awakening”: Walid’s ... of published author, Julianne Hale, a consultant for the Intelligence Community. For ... focusing on the Near East region. Julianne has written hundreds of reports ...
(Date:8/22/2017)... ... August 22, 2017 , ... ... is the Founder and Managing Member for t4 Leadership Development & Consulting. He ... to his definition of “success”: physician leadership development, servant leadership, data driven process ...
Breaking Medicine News(10 mins):
(Date:8/11/2017)... Aug. 11, 2017 DarioHealth Corp. (NASDAQ: DRIO), ... and big data solutions, today announced that it will ... 14 and host a conference call at 9:00am ET. ... and financial results and its strategy and outlook for ... by Erez Raphael , Chief Executive Officer, and ...
(Date:8/8/2017)... Aug. 8, 2017   ... diluted (GAAP) loss per share from continuing operations ... revenues increased 16 percent to $110 million ... 27 percent to $161 million ... from continuing operations increased 8 percent to $0.93 ...
(Date:8/7/2017)... FLINT, Mich. , Aug. 7, 2017 Diplomat ... appointment of Joel Saban as president, effective Aug. ... Paul Urick has decided to pursue other interests and ... period. "During his tenure, Paul has served us in multiple ... Burman,s Specialty Pharmacy in Jun. 2015 and has provided decisive, ...
Breaking Medicine Technology: