Navigation Links
Study identifies protein that helps developing germ cells wipe genes clean of past imprints
Date:12/4/2013

BOSTON, December 3, 2013 A protein called Tet1 is partly responsible for giving primordial germ cells a clean epigenetic slate before developing into sperm and egg cells, according to a new study by researchers at Boston Children's Hospital. This discovery could help provide clues to the cause of some kinds of neonatal growth defects and may also help advance the development of stem cell models of disease.

The findings were reported online Dec. 1 in Nature by a research team led by Yi Zhang, PhD, and Shinpei Yamaguchi, PhD, of Boston Children's Program in Cellular and Molecular Medicine.

Each of our cells carries two copies, or alleles, of every gene in our genome, one from each parent. In certain genes, one allele is imprintedmarked with small chemical tags called methyl groupsto keep it silent and prevent biological conflicts from arising between the two copies.

Before they mature into sperm or egg cells, primordial germ cells' imprinting patterns are erased and then re-established in an allele-specific manner. This process ensures that in the developing embryo only one member of each pair of alleles is expressed.

Zhang and Yamaguchi showed in a mouse model lacking the Tet1 gene that loss of the Tet1 protein prevented primordial germ cells from erasing their imprints, leading to embryonic lethality and reductions in the size of live-born offspring. The results suggest that Tet1 mutations may contribute to certain human birth defects and also provide insight into the mechanisms underlying the erasure process.

"We've long known what proteins are responsible for establishing imprinting patterns," says Zhang. "How erasure occurs has been less clear.

"We realize that Tet1 does not act alone in the erasure of genomic imprints, but is one important factor," he added. "We need to do additional work to understand what other proteins are involved."

Zhang noted that proper imprinting also has a role
'/>"/>

Contact: Erin Tornatore
erin.tornatore@childrens.harvard.edu
617-919-3110
Boston Children's Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study finds that carbon monoxide can help shrink tumors and amplify effectiveness of chemotherapy
2. 3-D mammography increases cancer detection and reduces call-back rates, Penn study finds
3. Tragara Initiates Clinical Study of TG02 in Combination with Carfilzomib in Multiple Myeloma
4. International study finds heart disease similar in men and women
5. 3D mammography increases cancer detection and reduces call-back rates, Penn study finds
6. Osteoporosis drugs compared for side effects, efficacy in Loyola study
7. Agein Corporation Responds to Stanford University Study and Warns Against Using Household Bleach as an Anti-Aging Skin Treatment
8. 2013 U.S. Image Exchange Study Released
9. Pradaxa Bleeding Allegations Lawyer: Resource4thePeople Reports New Study May Produce Treatment to Reverse Anti-Clotting Medication Effects
10. Global study reveals pandemic of untreated cancer pain due to over-regulation of pain medicines
11. Vanderbilt study finds limited resources for injured surgeons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... CA (PRWEB) August 21, 2014 The costs for ... past two decades, according to new insurance industry studies. The Quotes ... insurance finder to locate affordable plans from all 50 states at ... pays more than $50 for a routine visit or complex surgery ... coverage. Every user of the system will be asked to provide ...
(Date:8/21/2014)... Heights, MI (PRWEB) August 21, 2014 ... emails informing a taxpayer that their federal tax payment ... email domain appears to come from the IRS, “tax@irs.gov”, ... victims to provide personal and financial information. , While ... years now, an uptick in phishing activity is occurring ...
(Date:8/21/2014)... exercise is a challenge. Thankfully, there are Zombies chasing you. ... more than 31,000 health and fitness apps on the market ... use games to increase physical activity. , Gamification is currently ... cash in to help people get fit. Whether or not ... , "It,s just been assumed that gamified apps will work, ...
(Date:8/21/2014)... Texas MD Anderson Cancer Center today announced a new ... screening at a network of community breast care centers ... November, MD Anderson will become the exclusive provider of ... 10 breast care centers, located in Memorial City, The ... the network will expand to Memorial Hermann,s locations in ...
(Date:8/21/2014)... Aug. 21, 2014 (HealthDay News) -- Black mothers are ... and here,s one possible reason why: Hospitals in neighborhoods ... than those in areas with more white residents, a ... breast-feeding are much less common in medical centers where ... the U.S. Centers for Disease Control and Prevention reported ...
Breaking Medicine News(10 mins):Health News:Pet Insurance Finder for 50 States Launched at Insurance Website Online 2Health News:Beware Of Phony “Tax Payment Rejected” IRS Emails 2Health News:Playing hunger games: Are gamified health apps putting odds in your favor? 2Health News:MD Anderson and Memorial Hermann to operate breast screening network across Houston area 2Health News:Racial Disparities in Breast-Feeding May Start With Hospitals, Study Suggests 2
... the nation,s leader in pain prescription monitoring, announced ... with Aetna to offer Aetna,s network of providers ... monitoring process. Ameritox,s patented Rx Guardian(SM) methodology is ... a patented methodology to help physicians assess whether ...
... The Ohio State University , Cardinal Health and ... a collaboration that will invest more than $10 million ... industry, combining Ohio State,s Wright Center of Innovation in ... commercialization expertise for molecular imaging agents.Molecular imaging is one ...
... LINE OF NATURAL, NON-TOXIC AND EFFECTIVE HOUSEHOLD CLEANERS OFFER ... FAMILIES CLEAN AND SAFENEW YORK, April 29 ... Kevin Schwartz and Keith Garber of KAS Direct, founders ... cleaning solutions for households with infants and growing families ...
... Security Intelligence, and Risk Management Tools Now All in One ... ... swine flu, political instability, kidnapping and piracy dominating global headlines, MEDEX ... intelligence across medical, security, travel and risk management disciplines. By ...
... released today by the Center to Expose and Close Animal ... Close Animal Factories (CECAF) will hold a media teleconference to ... "factories." Among the topics will be Smithfield Foods at ... Officials in Mexico are looking at "manure lagoons" and ...
... Action to Protect Public,s Oral HealthCHICAGO, April 29 ... exclusively for the general dentist, reminds legislators that dentistry is ... must be taken into consideration in any effort by Congress ... critical issue for general dentistry is access to care. The ...
Cached Medicine News:Health News:Ameritox(R) Contracts With Aetna for Prescription Drug Monitoring Services 2Health News:The Ohio State University, Cardinal Health, State of Ohio to Invest $10 Million to Advance Medical Imaging Industry 2Health News:Preventative Safety Tips Timed to Swine Flu Outbreak 2Health News:MEDEX Announces New, Enhanced and Customizable Member Center 2Health News:MEDEX Announces New, Enhanced and Customizable Member Center 3Health News:MEDEX Announces New, Enhanced and Customizable Member Center 4Health News:Academy of General Dentistry Access to Care White Paper 2
(Date:8/21/2014)... Mass. , Aug. 21, 2014  Decision ... COPD,  physicians in Brazil ... follow clinical guidelines and commonly prescribe long-acting beta-agonist ... although they do so within current severe cost/coverage ... (FDCs) that are expected to launch in these ...
(Date:8/21/2014)... , N.Y. and HAMBURG, Germany , ... announced it is collaborating with Deutsches Elektronen-Synchrotron ( DESY ... Germany , to speed up management and storage ... Big Data and Analytics architecture based on IBM ... per second of data at peak performance and help ...
(Date:8/21/2014)... Aug. 21, 2014  Seventy-one percent of Americans believe the ... a serious public health and safety issue in ... survey released today by Repass & Partners, a ... "Americans understand the severity of the prescription medication abuse problem ... this very serious health situation facing our country," Rex ...
Breaking Medicine Technology:Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3Consumers Desperate For Measures To Curb Prescription Drug Abuse 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 3
... 2011 Columbia Laboratories, Inc. (Nasdaq: CBRX ) ... announced that the U.S. Food and Drug Administration (FDA) has ... ® (progesterone gel) for the reduction of risk of ... the mid-trimester of pregnancy. The acceptance of the NDA for ...
... (NASDAQ: OMER ) today reported that it has ... P2Y8 and OPN4. P2Y8 (also known as P2RY8) is associated ... white blood cells. ALL is the most common type of ... regulation of circadian rhythms, and could provide a target for ...
Cached Medicine Technology:Columbia Laboratories' NDA for PROCHIEVE® Vaginal Progesterone Gel Accepted for Filing by FDA 2Columbia Laboratories' NDA for PROCHIEVE® Vaginal Progesterone Gel Accepted for Filing by FDA 3Columbia Laboratories' NDA for PROCHIEVE® Vaginal Progesterone Gel Accepted for Filing by FDA 4Omeros Unlocks Orphan GPCRs Linked to Leukemia and Sleep Disorders 2Omeros Unlocks Orphan GPCRs Linked to Leukemia and Sleep Disorders 3Omeros Unlocks Orphan GPCRs Linked to Leukemia and Sleep Disorders 4
... Knee System is a long term, quality ... Available in both posterior stabilized and anatomically ... System provides the flexibility needed to address ... ease of identification keeps the user in ...
... Virtual Fluoroscopy software from ... has incorporated ease of ... features such as multiplanar ... models of image guided ...
... T.L.I.F. SG Instruments are the next evolution ... comprehensive and functionally sound instruments.. The T.L.I.F. ... disc removal and disc preparation instruments designed ... Excellent design, a wide range of instrument ...
... is a family of multislice CT scanners. ... Mx8000 also is available in an affordable ... same friendly user interface, advanced applications and ... Dual and Quad systems can be upgraded ...
Medicine Products: