Navigation Links
Study identifies protein that helps developing germ cells wipe genes clean of past imprints

BOSTON, December 3, 2013 A protein called Tet1 is partly responsible for giving primordial germ cells a clean epigenetic slate before developing into sperm and egg cells, according to a new study by researchers at Boston Children's Hospital. This discovery could help provide clues to the cause of some kinds of neonatal growth defects and may also help advance the development of stem cell models of disease.

The findings were reported online Dec. 1 in Nature by a research team led by Yi Zhang, PhD, and Shinpei Yamaguchi, PhD, of Boston Children's Program in Cellular and Molecular Medicine.

Each of our cells carries two copies, or alleles, of every gene in our genome, one from each parent. In certain genes, one allele is imprintedmarked with small chemical tags called methyl groupsto keep it silent and prevent biological conflicts from arising between the two copies.

Before they mature into sperm or egg cells, primordial germ cells' imprinting patterns are erased and then re-established in an allele-specific manner. This process ensures that in the developing embryo only one member of each pair of alleles is expressed.

Zhang and Yamaguchi showed in a mouse model lacking the Tet1 gene that loss of the Tet1 protein prevented primordial germ cells from erasing their imprints, leading to embryonic lethality and reductions in the size of live-born offspring. The results suggest that Tet1 mutations may contribute to certain human birth defects and also provide insight into the mechanisms underlying the erasure process.

"We've long known what proteins are responsible for establishing imprinting patterns," says Zhang. "How erasure occurs has been less clear.

"We realize that Tet1 does not act alone in the erasure of genomic imprints, but is one important factor," he added. "We need to do additional work to understand what other proteins are involved."

Zhang noted that proper imprinting also has a role in cellular reprogramming, such as the generation of induced pluripotent stem (iPS) cells.

"Proper imprinting pattern is critical for the maintenance of normal development and differentiation, but abnormal imprinting pattern is frequently observed in iPS cells after reprogramming," he explained. "Understanding how imprints are erased could lead to more effective methods of high-quality iPS cell generation."


Contact: Erin Tornatore
Boston Children's Hospital

Related medicine news :

1. Study finds that carbon monoxide can help shrink tumors and amplify effectiveness of chemotherapy
2. 3-D mammography increases cancer detection and reduces call-back rates, Penn study finds
3. Tragara Initiates Clinical Study of TG02 in Combination with Carfilzomib in Multiple Myeloma
4. International study finds heart disease similar in men and women
5. 3D mammography increases cancer detection and reduces call-back rates, Penn study finds
6. Osteoporosis drugs compared for side effects, efficacy in Loyola study
7. Agein Corporation Responds to Stanford University Study and Warns Against Using Household Bleach as an Anti-Aging Skin Treatment
8. 2013 U.S. Image Exchange Study Released
9. Pradaxa Bleeding Allegations Lawyer: Resource4thePeople Reports New Study May Produce Treatment to Reverse Anti-Clotting Medication Effects
10. Global study reveals pandemic of untreated cancer pain due to over-regulation of pain medicines
11. Vanderbilt study finds limited resources for injured surgeons
Post Your Comments:
(Date:10/13/2015)... Nashville, Tennessee (PRWEB) , ... October 13, 2015 ... ... owned leader of anesthesia and pain management services, today announced its partnership with ... the partnership integrates data from disparate systems and organizes the data into an ...
(Date:10/13/2015)... ... October 13, 2015 , ... ProText Kinetic Panel is ... With ProText Kinetic Panel, users can create energetic text animations in any layout without ... the Final Cut Pro X timeline and stylize the text. With intuitive on-screen controls, ...
(Date:10/13/2015)... ... October 13, 2015 , ... Element ... products, introduced a new company, RightSensor™ LLC, an Internet of Things (IoT) hardware ... RightSensor™ provides a fully-managed approach for customers requiring sensor hardware for critical data ...
(Date:10/13/2015)... CA (PRWEB) , ... October 13, 2015 , ... Dr. ... by Medical New Today on September 18, 2015. The research, which was conducted at ... Dr. Wael Sabbah and colleagues, show connections between stress during pregnancy and future dental ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... A child ... that’s why SmileCareClub , the leading remote invisible aligner system, has joined with ... would otherwise go without it. For each aligner treatment plan purchased, SmileCareClub will donate ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... , Oct. 13, 2015  Mylan N.V. (Nasdaq: ... 5:00 p.m. ET host a conference call and webcast to ... plc (NYSE: PRGO ; TASE) shareholders through Mylan,s offer ... Mylan,s Executive Chairman Robert J. Coury , CEO ... --> --> Mylan will ...
(Date:10/13/2015)... -- Synapse Biomedical Inc. ( ) reported today that ... use of the NeuRx ® Diaphragm Pacing System ... the United States and patient ... PAS study group met their initial enrollment goal ahead ... expanded the enrollment target to 150 participants.   ...
(Date:10/13/2015)... COLLEGE PARK, Md. , Oct. 13, 2015 ... hubs is the biggest key to growing Baltimore ... to a report released today by the Maryland Technology ... already has many of the pieces in place to support ... Martha Connolly , director of Mtech Baltimore. "This study is ...
Breaking Medicine Technology: