Navigation Links
Study identifies protein that helps developing germ cells wipe genes clean of past imprints
Date:12/4/2013

BOSTON, December 3, 2013 A protein called Tet1 is partly responsible for giving primordial germ cells a clean epigenetic slate before developing into sperm and egg cells, according to a new study by researchers at Boston Children's Hospital. This discovery could help provide clues to the cause of some kinds of neonatal growth defects and may also help advance the development of stem cell models of disease.

The findings were reported online Dec. 1 in Nature by a research team led by Yi Zhang, PhD, and Shinpei Yamaguchi, PhD, of Boston Children's Program in Cellular and Molecular Medicine.

Each of our cells carries two copies, or alleles, of every gene in our genome, one from each parent. In certain genes, one allele is imprintedmarked with small chemical tags called methyl groupsto keep it silent and prevent biological conflicts from arising between the two copies.

Before they mature into sperm or egg cells, primordial germ cells' imprinting patterns are erased and then re-established in an allele-specific manner. This process ensures that in the developing embryo only one member of each pair of alleles is expressed.

Zhang and Yamaguchi showed in a mouse model lacking the Tet1 gene that loss of the Tet1 protein prevented primordial germ cells from erasing their imprints, leading to embryonic lethality and reductions in the size of live-born offspring. The results suggest that Tet1 mutations may contribute to certain human birth defects and also provide insight into the mechanisms underlying the erasure process.

"We've long known what proteins are responsible for establishing imprinting patterns," says Zhang. "How erasure occurs has been less clear.

"We realize that Tet1 does not act alone in the erasure of genomic imprints, but is one important factor," he added. "We need to do additional work to understand what other proteins are involved."

Zhang noted that proper imprinting also has a role in cellular reprogramming, such as the generation of induced pluripotent stem (iPS) cells.

"Proper imprinting pattern is critical for the maintenance of normal development and differentiation, but abnormal imprinting pattern is frequently observed in iPS cells after reprogramming," he explained. "Understanding how imprints are erased could lead to more effective methods of high-quality iPS cell generation."


'/>"/>

Contact: Erin Tornatore
erin.tornatore@childrens.harvard.edu
617-919-3110
Boston Children's Hospital
Source:Eurekalert

Related medicine news :

1. Study finds that carbon monoxide can help shrink tumors and amplify effectiveness of chemotherapy
2. 3-D mammography increases cancer detection and reduces call-back rates, Penn study finds
3. Tragara Initiates Clinical Study of TG02 in Combination with Carfilzomib in Multiple Myeloma
4. International study finds heart disease similar in men and women
5. 3D mammography increases cancer detection and reduces call-back rates, Penn study finds
6. Osteoporosis drugs compared for side effects, efficacy in Loyola study
7. Agein Corporation Responds to Stanford University Study and Warns Against Using Household Bleach as an Anti-Aging Skin Treatment
8. 2013 U.S. Image Exchange Study Released
9. Pradaxa Bleeding Allegations Lawyer: Resource4thePeople Reports New Study May Produce Treatment to Reverse Anti-Clotting Medication Effects
10. Global study reveals pandemic of untreated cancer pain due to over-regulation of pain medicines
11. Vanderbilt study finds limited resources for injured surgeons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2017)... BROOK, Ill. (PRWEB) , ... February 20, 2017 ... ... potential to reduce the rate at which women are called back for additional ... the journal Radiology . , In 2011, the U.S. Food and Drug ...
(Date:2/20/2017)... ... February 20, 2017 , ... MRI screening improves early ... new study from Germany published online in the journal Radiology . , ... better sensitivity than mammography and ultrasound. Currently, guidelines reserve breast MRI screening for women ...
(Date:2/20/2017)... Wis. (PRWEB) , ... February 21, 2017 , ... ... guidebook offering readers a way to “ Getting Over the Bump in the Road ... tips and lessons learned on how to cope with the ups and downs experienced ...
(Date:2/20/2017)... ... February 20, 2017 , ... ... that supports the proper levels of “good” bacteria in the body, announced its ... nutritional products website. , Daily Body Restore® is made with a unique ...
(Date:2/20/2017)... ... February 20, 2017 , ... Silverado today is pleased ... open and operate a state-of-the-art memory care community in Alexandria, Virginia. The new community ... site just outside of Old Town. , The three-story community with underground parking ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... 2017 EU5 Magnetic Resonance Imaging (MRI) Systems Market Outlook ... ... (MRI) Systems Market Outlook to 2022", provides key market data on ... value, in millions of US dollars, volume (in units) and average ... MRI Systems. The report also provides company shares ...
(Date:2/20/2017)... 21, 2017 Taiwan Biophotonic Co. (tBPC), a ... vital signs sensing solutions, today announced the CE Marking ... pulse oximeter, the oCare TM Pro 100, which is ... medical devices space.  tBPC,s Wrist Pulse Oximeter, ... simple and reliable method to measure and record heart ...
(Date:2/20/2017)... TEMPE, Ariz. , Feb. 20, 2017 /PRNewswire/ ... to the medical device industry, announced today that ... Vention Medical,s Device Manufacturing Services business.  ... bolsters its position as a leading services provider ... MedPlast,s acquisition will further expand the company,s ...
Breaking Medicine Technology: