Navigation Links
Study identifies protein essential for normal heart function
Date:6/17/2013

A study by researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences and the Department of Pharmacology at the University of California, San Diego, shows that a protein called MCL-1, which promotes cell survival, is essential for normal heart function.

Their study, published in the June 15 online issue of the journal Genes & Development, found that deletion of the gene encoding MCL-1 in adult mouse hearts led to rapid heart failure within two weeks, and death within a month.

MCL-1 (myeloid cell leukemia-1) is an anti-apoptotic protein, meaning that it prevents or delays the death of a cell. It is also a member of the BCL-2 family of proteins that regulate mitochondria the cell's power producers and cell death. Aberrant expression of anti-apoptotic BCL-2 family members is one of the defining features of cancer cells, and is strongly associated with resistance to current therapies. Thus, these proteins are currently major targets in the development of new therapies for patients with cancer.

But, while MCL-1 is up regulated in a number of human cancers, contributing to the overgrowth of cancer cells, it is found at high levels in normal heart tissue. Additionally, the researchers found that autophagy a process which deals with mitochondrial maintenance and is normally induced by myocardial stress was impaired in mice with MCL-1 deficient hearts.

In summary, the study demonstrated that the loss of MCL-1 led to rapid dysfunction of mitochondria, impaired autophagy and heart failure, even in the absence of cardiac stress.

"Cardiac injury, such as a heart attack, causes levels of MCL-1 to drop in the heart, and this process may increase cardiac cell death," said sa B. Gustafsson, PhD, an associate professor at UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences. "Therefore, preserving normal levels of this protein in cardiac tissue could reduce damage after a heart attack and prevent progr
'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study finds racial and ethnic disparities in usage of specialty services for children with autism
2. Study Finds Individuals with Arthritis Don’t Walk Enough, Allsup Reports
3. Older patients will make lifestyle changes to avoid fractures, study finds
4. Loopholes in Federally Mandated IVF Reporting Lead Some Clinics to Artificially Inflate IVF Pregnancy Rates, Center for Human Reproduction Study Reports
5. Study Shows Alcohol Abusers Cannot Depend on Their Designated Drivers
6. UF study finds brain-imaging technique can help diagnose movement disorders
7. First major study of suicide motivations to advance prevention
8. Insurance Service Center Discusses a Recent Health Study and Encourages the Wisconsin Community to Purchase Adequate Health Coverage to Avoid a Financial Disaster
9. Study Identifies Most Effective Natural Bed Bug Killer
10. Clearwater, FL Periodontist, Dr. Stephen Kobernick Cites Recent Periodontal Study Urging Patients to Seek Gum Disease Treatment
11. Self-defense training for Kenyan girls reduces rape, Stanford/Packard study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... Texas (PRWEB) May 06, 2015 ... of the HIMSS EMR Adoption Model, the hospital ... improve patient engagement and automate processes. The leadership ... from paper-driven to electronic workflows, patient registration still ... copies of consents. With HIMSS Stage 7 attestation ...
(Date:5/6/2015)... (PRWEB) May 06, 2015 Corporate ... behalf of MEBC, an Alliance Award for excellence ... during FOCUS 2015, JDA’s annual user conference which ... retail and wholesale distribution sectors. This award recognizes ... are receiving services that advance their supply chain ...
(Date:5/6/2015)... 06, 2015 The Beryl Institute announces ... of Patient Experience Journal (PXJ), an international, open access, ... understanding and improving patient experience. The second volume of ... conversation globally, helps align the voices engaged and provides ... Published in association with The Beryl Institute, Volume 2, ...
(Date:5/6/2015)... Marketing Maven announces a ... sanitation and hygiene nonprofit by GuideStar’s Philanthropedia. , “WaterAid ... and it brings our agency great joy to work ... “The ongoing relationship between WaterAid and Marketing ... learn about and support the nonprofit as they aim ...
(Date:5/6/2015)... 06, 2015 Wolters Kluwer , ... and students, announced today that in a survey of ... use of the clinical decision support resource improves the ... of 2014, UpToDate users in more than 170 countries ... month, on average. In Germany alone, 95% of all ...
Breaking Medicine News(10 mins):Health News:Access Electronic Patient Signatures Help Hilo Meet HIMSS Stage 7 Paperless Targets & Save $200,000 a Year on Consent Forms 2Health News:Access Electronic Patient Signatures Help Hilo Meet HIMSS Stage 7 Paperless Targets & Save $200,000 a Year on Consent Forms 3Health News:MEBC Receives Award for Consulting Excellence in Retail 2Health News:Patient Experience Journal Releases Spring 2015 Issue 2Health News:Marketing Maven Expands Partnership with the #1 Ranked International Water, Sanitation and Hygiene Nonprofit 2Health News:Marketing Maven Expands Partnership with the #1 Ranked International Water, Sanitation and Hygiene Nonprofit 3Health News:Current, Evidence-Based Knowledge for Physicians: UpToDate supports quick and accurate decision support for diagnosis and treatment 2Health News:Current, Evidence-Based Knowledge for Physicians: UpToDate supports quick and accurate decision support for diagnosis and treatment 3
... 500 Executive Driving Global Breast Cancer Leader,s Promise ... End Breast Cancer Forever, ATLANTA, Jan. 12 Hala ... the global leader in the fight to end breast,cancer forever, ... annual Trumpet Awards event in Atlanta with a ,High Heels ...
... Diseases than Ever ... ... childhood influenza and adolescent meningococcal,vaccinations are included in the 2008 Childhood ... Control and,Prevention (CDC), the American Academy of Pediatrics (AAP), and the,American ...
... NEW YORK, Jan. 11 The Substance Abuse ... from the National Survey on Drug Use and ... S. aged 12 to 25 have abused non-prescription,over-the- ... high at least once,in their lifetime. This announcement ...
... health care reform is too important, the stakes for, Californians ... ... changes., SACRAMENTO, Calif., Jan. 11 As the ... hammered out by Governor Arnold Schwarzenegger and Assembly,Speaker Fabian Nunez, the state,s ...
... genetic, biological causes could lead more to feel comfortable ... When people understand the genetics and biology of anorexia ... the eating disorder for their illness, says a University ... , "This is a potentially important finding because it ...
... diet and lifestyle are at root of reduced risk, , , FRIDAY, ... in your blood may reduce your risk of stroke, new research ... C in their blood had a 42 percent lower risk of ... which is in the January issue of The ...
Cached Medicine News:Health News:Susan G. Komen for the Cure's CEO Hala Moddelmog Earns 'High Heels in High Places' Recognition at 2008 Trumpet Awards 2Health News:Susan G. Komen for the Cure's CEO Hala Moddelmog Earns 'High Heels in High Places' Recognition at 2008 Trumpet Awards 3Health News:Health Groups Release 2008 Immunization Schedules 2Health News:Statement of Steve Pasierb, President and CEO, Partnership for a Drug-Free America on New SAMHSA Study On Cough Medicine Abuse 2Health News:Statement of Steve Pasierb, President and CEO, Partnership for a Drug-Free America on New SAMHSA Study On Cough Medicine Abuse 3Health News:Statement of Steve Pasierb, President and CEO, Partnership for a Drug-Free America on New SAMHSA Study On Cough Medicine Abuse 4Health News:Insurance Agents Call for State Senate to Improve California's Health Care Reform Compromise 2Health News:Science Could Erase Stigma of Anorexia 2Health News:Vitamin C May Play Role in Stroke Prevention 2Health News:Vitamin C May Play Role in Stroke Prevention 3
(Date:5/6/2015)... 2015 Asterias Biotherapeutics, Inc. (NYSE MKT: ... field of regenerative medicine, today announced that the ... community to review the clinical development strategy for ... on Friday, May 8, 2015. Topics will include ... planned clinical activities for AST-OPC1. ...
(Date:5/6/2015)... 2015 Delcath Systems, Inc. (NASDAQ: DCTH ... on oncology with an emphasis on the treatment of ... the three months ended March 31, 2015.  ... include: , Achieved quarterly product revenue of $0.44 ... the first quarter of 2014; , Activated a ...
(Date:5/6/2015)... Health (NYSE: CVS ) officially announced today that it will ... heavy fire damage during protests last week.  "As we ... the past week or so, our hearts turned from pain to ... CEO Larry Merlo . "Our purpose as a company is ... better way that we can fulfill that purpose than to reopen ...
Breaking Medicine Technology:Asterias Biotherapeutics to Host Investor Meeting to Review Clinical Development Strategy for AST-OPC1 in Spinal Cord Injury 2Asterias Biotherapeutics to Host Investor Meeting to Review Clinical Development Strategy for AST-OPC1 in Spinal Cord Injury 3Delcath Reports 2015 First Quarter Financial Results 2Delcath Reports 2015 First Quarter Financial Results 3Delcath Reports 2015 First Quarter Financial Results 4Delcath Reports 2015 First Quarter Financial Results 5Delcath Reports 2015 First Quarter Financial Results 6Delcath Reports 2015 First Quarter Financial Results 7Delcath Reports 2015 First Quarter Financial Results 8CVS Health Announces it Will Rebuild Baltimore CVS/pharmacy Locations 2
Microseal 'F' foil, seals plates for cold storage (or cycling >25l), disposable, pkg of 100...
Pkg qty: box of 2 bags pack of 25 (Pack = Zippered Bag)...
Transparent film for easy visual monitoring of samples...
... Biosystems has developed a comprehensive set ... using sequence detection systems (SDS) reagents ... and easy to follow. Many traditional ... and the thermal cycling protocol itself, ...
Medicine Products: